Myelin disorders and stem cells: as therapies and models

Fatmagül İlayda AYDINLI; Eşref ÇELİK; Burcu Kurt VATANDAŞLAR; Bilal Ersen KERMAN

Makale detayları

Myelin disorders and stem cells: as therapies and models

Yazarlar:

Fatmagül İlayda AYDINLI | Eşref ÇELİK | Burcu Kurt VATANDAŞLAR | Bilal Ersen KERMAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2016 Vol.40 Issue 5, pp.1068-1080

Belge Tipi:

Makale

Yayın Tarihi:

9/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000811582

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Özet:

 

Myelin disorders burden millions of people around the world, yet existing therapies are inadequate to cure them. Current remedies commonly treat the symptoms with minimal to no effect on the actual cause of the disorder. The basis and/or the mechanism of demyelination is not known for many of the disorders either. In recent years, stem cells of variable origin have been used in clinical trials as transplant agents to restore the defective biochemical process or the damaged tissue. We summarize the outcomes of these trials for demyelination disorders. The capability of reprograming mature cells into stem cells equips researchers with a new tool to replicate disease phenotypes in cell culture dishes for basic research and therapeutic screens. The applications of in vitro myelination disorder models are also discussed. The combined outcome of the discussed studies offers a promising future as stem cell transplantation generally results in decreased symptoms and improved quality of life. However, the mechanism of action of the interventions is not known and in cases of negative outcomes the reasons are usually obscure. Further basic science studies along with clinical interventions should close the knowledge gap and should help spread the positive results to a larger population.

Makale detayları

Myelin disorders and stem cells: as therapies and models

Yazarlar: Fatmagül İlayda AYDINLI | Eşref ÇELİK | Burcu Kurt VATANDAŞLAR | Bilal Ersen KERMAN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Biology 2016 Vol.40 Issue 5, pp.1068-1080

Belge Tipi: Makale

Yayın Tarihi: 9/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000811582

Sıklık: İki Aylık

eISSN: 1303-6092

pISSN: 1300-0152

Sayı

Yazarlar:

Fatmagül İlayda AYDINLI | Eşref ÇELİK | Burcu Kurt VATANDAŞLAR | Bilal Ersen KERMAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2016 Vol.40 Issue 5, pp.1068-1080

Belge Tipi:

Makale

Yayın Tarihi:

9/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000811582

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152