Correlation of Invasion Parameters in Basal Cell Carcinoma with Pre-diagnostic Vitamin D Insufficiency Levels

Damla Gül Fındık; Özlem Türelik

Makale detayları

Correlation of Invasion Parameters in Basal Cell Carcinoma with Pre-diagnostic Vitamin D Insufficiency Levels

Yazarlar:

Damla Gül Fındık | Özlem Türelik

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Pathology

Dergi:

Journal of Basic and Clinical Health Sciences Vol.9 Issue 3, pp.672-677

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359205

pISSN:

2564-7288

Anahtar kelimeler:

Özet:

 Purpose: The relationship between vitamin D and non-melanoma skin cancers remains controversial. Elevated serum vitamin D levels above 60 nmolL 24 ngmL have been linked to increased basal cell carcinoma risk. The study aims to investigate the association of tumor invasion parameters in basal cell carcinoma with vitamin D insufficiency levels. Material and Methods: Retrospective examination of basal cell carcinoma cases 2014-2024 with serum vitamin D levels 25ngmL. Histopathological analysis measured Breslow thickness and evaluated Clark level. Results: The study included 45.5 males and 54.5 females, mean age 67.958.6 years. Mean vitamin D levels were 15.696.56 ngmL. Non-aggressive histologic types showed lower Clark levels p0.05. High Clark level group had thicker Breslow 2409.2  253.05 μm than low Clark level group 2120.13  832.19 μm p0.05. However, no significant difference in mean vitamin D levels was observed in either the Clark level or localization groups. Serum vitamin D level did not correlate with Breslow thickness or Clark level p0.05. Conclusion: In basal cell carcinoma cases with vitamin D insufficiency, serum vitamin D level does not correlate with Clark level or Breslow thickness. Therefore, prediagnostic vitamin D insufficiency levels in basal cell carcinoma are not significantly associated with invasion parameters.

 Purpose: The relationship between vitamin D and non-melanoma skin cancers remains controversial. Elevated serum vitamin D levels above 60 nmolL 24 ngmL have been linked to increased basal cell carcinoma risk. The study aims to investigate the association of tumor invasion parameters in basal cell carcinoma with vitamin D insufficiency levels. Material and Methods: Retrospective examination of basal cell carcinoma cases 2014-2024 with serum vitamin D levels 25ngmL. Histopathological analysis measured Breslow thickness and evaluated Clark level. Results: The study included 45.5 males and 54.5 females, mean age 67.958.6 years. Mean vitamin D levels were 15.696.56 ngmL. Non-aggressive histologic types showed lower Clark levels p0.05. High Clark level group had thicker Breslow 2409.2  253.05 μm than low Clark level group 2120.13  832.19 μm p0.05. However, no significant difference in mean vitamin D levels was observed in either the Clark level or localization groups. Serum vitamin D level did not correlate with Breslow thickness or Clark level p0.05. Conclusion: In basal cell carcinoma cases with vitamin D insufficiency, serum vitamin D level does not correlate with Clark level or Breslow thickness. Therefore, prediagnostic vitamin D insufficiency levels in basal cell carcinoma are not significantly associated with invasion parameters.

 Purpose: The relationship between vitamin D and non-melanoma skin cancers remains controversial. Elevated serum vitamin D levels above 60 nmolL 24 ngmL have been linked to increased basal cell carcinoma risk. The study aims to investigate the association of tumor invasion parameters in basal cell carcinoma with vitamin D insufficiency levels. Material and Methods: Retrospective examination of basal cell carcinoma cases 2014-2024 with serum vitamin D levels 25ngmL. Histopathological analysis measured Breslow thickness and evaluated Clark level. Results: The study included 45.5 males and 54.5 females, mean age 67.958.6 years. Mean vitamin D levels were 15.696.56 ngmL. Non-aggressive histologic types showed lower Clark levels p0.05. High Clark level group had thicker Breslow 2409.2  253.05 μm than low Clark level group 2120.13  832.19 μm p0.05. However, no significant difference in mean vitamin D levels was observed in either the Clark level or localization groups. Serum vitamin D level did not correlate with Breslow thickness or Clark level p0.05. Conclusion: In basal cell carcinoma cases with vitamin D insufficiency, serum vitamin D level does not correlate with Clark level or Breslow thickness. Therefore, prediagnostic vitamin D insufficiency levels in basal cell carcinoma are not significantly associated with invasion parameters.

 Purpose: The relationship between vitamin D and non-melanoma skin cancers remains controversial. Elevated serum vitamin D levels above 60 nmolL 24 ngmL have been linked to increased basal cell carcinoma risk. The study aims to investigate the association of tumor invasion parameters in basal cell carcinoma with vitamin D insufficiency levels. Material and Methods: Retrospective examination of basal cell carcinoma cases 2014-2024 with serum vitamin D levels 25ngmL. Histopathological analysis measured Breslow thickness and evaluated Clark level. Results: The study included 45.5 males and 54.5 females, mean age 67.958.6 years. Mean vitamin D levels were 15.696.56 ngmL. Non-aggressive histologic types showed lower Clark levels p0.05. High Clark level group had thicker Breslow 2409.2  253.05 μm than low Clark level group 2120.13  832.19 μm p0.05. However, no significant difference in mean vitamin D levels was observed in either the Clark level or localization groups. Serum vitamin D level did not correlate with Breslow thickness or Clark level p0.05. Conclusion: In basal cell carcinoma cases with vitamin D insufficiency, serum vitamin D level does not correlate with Clark level or Breslow thickness. Therefore, prediagnostic vitamin D insufficiency levels in basal cell carcinoma are not significantly associated with invasion parameters.

Makale detayları

Correlation of Invasion Parameters in Basal Cell Carcinoma with Pre-diagnostic Vitamin D Insufficiency Levels

Yazarlar:

Damla Gül Fındık | Özlem Türelik

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Pathology

Dergi:

Journal of Basic and Clinical Health Sciences Vol.9 Issue 3, pp.672-677

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359205

pISSN:

2564-7288

Calcifediol

Neoplasm Invasiveness

Skin Neoplasms

Sayı

Makale detayları

Correlation of Invasion Parameters in Basal Cell Carcinoma with Pre-diagnostic Vitamin D Insufficiency Levels

Yazarlar: Damla Gül Fındık | Özlem Türelik

Yayıncı: Dokuz Eylul University

Ana Başlıklar: Pathology

Dergi: Journal of Basic and Clinical Health Sciences Vol.9 Issue 3, pp.672-677

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001359205

pISSN: 2564-7288

Calcifediol

Neoplasm Invasiveness

Skin Neoplasms

Sayı

Yazarlar:

Damla Gül Fındık | Özlem Türelik

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Pathology

Dergi:

Journal of Basic and Clinical Health Sciences Vol.9 Issue 3, pp.672-677

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359205

pISSN:

2564-7288