Glutamate transporter SLC1A1 is associated with clear cell renal cell carcinoma

Sercan ERGÜN; Sezgin GÜNEŞ; Recep BÜYÜKALPELLİ; Oğuz AYDIN

Makale detayları

Glutamate transporter SLC1A1 is associated with clear cell renal cell carcinoma

Yazarlar:

Sercan ERGÜN | Sezgin GÜNEŞ | Recep BÜYÜKALPELLİ | Oğuz AYDIN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.531-537

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000750183

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: This study aimed to comparatively analyze the expression levels of the SLC1A1 gene in renal specimens from tumors and adjacent healthy kidney tissues of patients with clear cell renal cell carcinoma (ccRCC).Material and methods: Nineteen patients diagnosed with ccRCC were included in the study. The expression levels of the SLC1A1 and GAPDH  genes  were  measured  in  tumor  and  formalin-fixed  paraffin-embedded  (FFPE)  tissue  specimens  from  the  adjacent  healthy  kidney of each subject. Via the GEPIA database, the distribution of SLC1A1 gene expressions in ccRCC and healthy kidney tissues was obtained. The relative expression of SLC1A1 was evaluated for the association with the clinical parameters of the patients. Results: The expression of the SLC1A1 gene was significantly higher in males than females (P = 0.029). Also, there were statistically significant associations between stages II-IV and Fuhrman grades 2-4 with respect to SLC1A1 gene expression (P < 0.001 for both). Moreover, low levels of red blood cell and hemoglobin counts were significantly associated with the SLC1A1 expression (P < 0.001 and P = 0.005, respectively). The expression of the SLC1A1 gene in tumor tissues increased approximately 3 times compared with normal kidney  tissues  (P  <  0.05).  According  to  the  GEPIA  database,  SLC1A1  gene  expression  is  significantly  higher  in  ccRCC  patients  than  healthy persons (P = 0.01). Conclusion: The change in the expression of SLC1A1 may be crucial for ccRCC pathophysiology.

Makale detayları

Glutamate transporter SLC1A1 is associated with clear cell renal cell carcinoma

Yazarlar: Sercan ERGÜN | Sezgin GÜNEŞ | Recep BÜYÜKALPELLİ | Oğuz AYDIN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.531-537

Belge Tipi: Makale

Yayın Tarihi: 3/2019

Belge Dili: Türkçe

Document ID (Org No.): 2000750183

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Sercan ERGÜN | Sezgin GÜNEŞ | Recep BÜYÜKALPELLİ | Oğuz AYDIN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.531-537

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000750183

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144