Synthesis and Antimicrobial Activities of 1,2,4-Oxadiazin-5-one, 6-one and 5-Thiones

Nevin ARIKAN; Doğan SÜMENGEN and Başaran DÜLGER

Makale detayları

Synthesis and Antimicrobial Activities of 1,2,4-Oxadiazin-5-one, 6-one and 5-Thiones

Yazarlar:

Nevin ARIKAN | Doğan SÜMENGEN and Başaran DÜLGER

Yayıncı:

TUBITAK

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Turkish Journal of Chemistry 2008 Vol.32 Issue 2, pp.147-155

Belge Tipi:

Makale

Yayın Tarihi:

1/2008

Belge Dili:

İngilizce

Document ID (Org No.):

2000728520

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

N-Substituted pyridine carboxamide oximes (2) were obtained  from the reactions of pyridine hydroxamic acid chloride hydrochlorides  (1) with primary amines.  The reactions of carboxamide oximes with  chloroacetyl chloride in the presence of triethylamine gave the  corresponding 3,4-disubstituted-1,2,4-oxadiazin-5-ones (3), which on  treatment with P2S5 gave in moderate yielded the corresponding  3,4-disubstituted-1,2,4-oxadiazin-5-thiones (4).  The reaction of  pyridine carboxamide oximes with a-aminoacid ester led to the  formation of 3,5-disubstituted-1,2,4-oxadiazin-6-ones (5) in moderate  yields.  The structures of the prepared compound were evaluated by  spectroscopy.  Some of the representatives of 3,4-disubstituted-1,2,4-  oxadiazin-5-ones, thiones, and 3,5-disubstituted-1,2,4-oxadiazin-6-ones  were screened for antibacterial activity using disc diffusion.  It was  found that all the tested compounds have good antimicrobial  activities.

 

N-Substituted pyridine carboxamide oximes (2) were obtained  from the reactions of pyridine hydroxamic acid chloride hydrochlorides  (1) with primary amines.  The reactions of carboxamide oximes with  chloroacetyl chloride in the presence of triethylamine gave the  corresponding 3,4-disubstituted-1,2,4-oxadiazin-5-ones (3), which on  treatment with P2S5 gave in moderate yielded the corresponding  3,4-disubstituted-1,2,4-oxadiazin-5-thiones (4).  The reaction of  pyridine carboxamide oximes with a-aminoacid ester led to the  formation of 3,5-disubstituted-1,2,4-oxadiazin-6-ones (5) in moderate  yields.  The structures of the prepared compound were evaluated by  spectroscopy.  Some of the representatives of 3,4-disubstituted-1,2,4-  oxadiazin-5-ones, thiones, and 3,5-disubstituted-1,2,4-oxadiazin-6-ones  were screened for antibacterial activity using disc diffusion.  It was  found that all the tested compounds have good antimicrobial  activities.

Makale detayları

Synthesis and Antimicrobial Activities of 1,2,4-Oxadiazin-5-one, 6-one and 5-Thiones

Yazarlar: Nevin ARIKAN | Doğan SÜMENGEN and Başaran DÜLGER

Yayıncı: TUBITAK

Ana Başlıklar: Kimya ve ilgili bilimler

Dergi: Turkish Journal of Chemistry 2008 Vol.32 Issue 2, pp.147-155

Belge Tipi: Makale

Yayın Tarihi: 1/2008

Belge Dili: İngilizce

Document ID (Org No.): 2000728520

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Nevin ARIKAN | Doğan SÜMENGEN and Başaran DÜLGER

Yayıncı:

TUBITAK

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Turkish Journal of Chemistry 2008 Vol.32 Issue 2, pp.147-155

Belge Tipi:

Makale

Yayın Tarihi:

1/2008

Belge Dili:

İngilizce

Document ID (Org No.):

2000728520

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527