Association of serum uric acid/albumin ratio with completely occluded infarct-related artery in patients with non-ST-segment elevation myocardial infarction

Orhan Karayiğit

Makale detayları

Association of serum uric acid/albumin ratio with completely occluded infarct-related artery in patients with non-ST-segment elevation myocardial infarction

Yazarlar:

Orhan Karayiğit

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Journal of Medicine and Palliative Care Vol.4 Issue 1, pp.21-27

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001281432

pISSN:

2717-7505

Anahtar kelimeler:

Özet:

 Aim: Infarct-related artery IRA patency before primary percutaneous coronary intervention pPCI is linked to improved clinical outcomes and lower mortality in patients with acute coronary syndrome. The purpose of this research was to examine the association between serum uric acidalbumin ratio UAR and IRA patency in patients with non-ST-segment elevation myocardial infarction NSTEMI. Material and Method: We evaluated 430 consecutive patients with NSTEMI in total retrospectively. The study population was divided into 2 groups according to the IRA patency as assessed by the degree of Thrombolysis in Myocardial Infarction TIMI flow before pPCI. As a result, completely occluded IRA was defined as TIMI grade 0-1, while patent IRA was defined as TIMI grade 2-3. Results: IRA was found to be occluded in 110 25.5 patients prior to the procedure. UAR level p0.001 was found to be higher among the patients with IRA occlusion when compared to the patent group. Regression analysis revealed that UAR OR:3.125; 95 CI:1.186-8.232, p0.001, left ventricular ejection fraction OR:0.917, 95 CI:0.885-0.951, p0.001 and culprit artery diameter OR:0.917, 95 CI:0.885-0.951, p0.001 were independent predictors for an occluded IRA. An UAR cut-off value of 1.40 was detected to prognosticate the occluded IRA with 62.7 sensitivity and 63.8 specificity AUC: 0.722, 95 CI: 0.671-0.773, p0.001. Conclusion: UAR is an independent predictor of preprocedural IRA patency in patients with NSTEMI. Thus, UAR may be an easily accessible parameter to diagnose high-risk NSTEMI patients who would benefit from an immediate invasive strategy 2 hours.

 Aim: Infarct-related artery IRA patency before primary percutaneous coronary intervention pPCI is linked to improved clinical outcomes and lower mortality in patients with acute coronary syndrome. The purpose of this research was to examine the association between serum uric acidalbumin ratio UAR and IRA patency in patients with non-ST-segment elevation myocardial infarction NSTEMI. Material and Method: We evaluated 430 consecutive patients with NSTEMI in total retrospectively. The study population was divided into 2 groups according to the IRA patency as assessed by the degree of Thrombolysis in Myocardial Infarction TIMI flow before pPCI. As a result, completely occluded IRA was defined as TIMI grade 0-1, while patent IRA was defined as TIMI grade 2-3. Results: IRA was found to be occluded in 110 25.5 patients prior to the procedure. UAR level p0.001 was found to be higher among the patients with IRA occlusion when compared to the patent group. Regression analysis revealed that UAR OR:3.125; 95 CI:1.186-8.232, p0.001, left ventricular ejection fraction OR:0.917, 95 CI:0.885-0.951, p0.001 and culprit artery diameter OR:0.917, 95 CI:0.885-0.951, p0.001 were independent predictors for an occluded IRA. An UAR cut-off value of 1.40 was detected to prognosticate the occluded IRA with 62.7 sensitivity and 63.8 specificity AUC: 0.722, 95 CI: 0.671-0.773, p0.001. Conclusion: UAR is an independent predictor of preprocedural IRA patency in patients with NSTEMI. Thus, UAR may be an easily accessible parameter to diagnose high-risk NSTEMI patients who would benefit from an immediate invasive strategy 2 hours.

 Aim: Infarct-related artery IRA patency before primary percutaneous coronary intervention pPCI is linked to improved clinical outcomes and lower mortality in patients with acute coronary syndrome. The purpose of this research was to examine the association between serum uric acidalbumin ratio UAR and IRA patency in patients with non-ST-segment elevation myocardial infarction NSTEMI. Material and Method: We evaluated 430 consecutive patients with NSTEMI in total retrospectively. The study population was divided into 2 groups according to the IRA patency as assessed by the degree of Thrombolysis in Myocardial Infarction TIMI flow before pPCI. As a result, completely occluded IRA was defined as TIMI grade 0-1, while patent IRA was defined as TIMI grade 2-3. Results: IRA was found to be occluded in 110 25.5 patients prior to the procedure. UAR level p0.001 was found to be higher among the patients with IRA occlusion when compared to the patent group. Regression analysis revealed that UAR OR:3.125; 95 CI:1.186-8.232, p0.001, left ventricular ejection fraction OR:0.917, 95 CI:0.885-0.951, p0.001 and culprit artery diameter OR:0.917, 95 CI:0.885-0.951, p0.001 were independent predictors for an occluded IRA. An UAR cut-off value of 1.40 was detected to prognosticate the occluded IRA with 62.7 sensitivity and 63.8 specificity AUC: 0.722, 95 CI: 0.671-0.773, p0.001. Conclusion: UAR is an independent predictor of preprocedural IRA patency in patients with NSTEMI. Thus, UAR may be an easily accessible parameter to diagnose high-risk NSTEMI patients who would benefit from an immediate invasive strategy 2 hours.

 Amaç: Akut koroner sendromlu hastalarda, primer perkütan koroner girişim PKG öncesi enfarkt ilişkili arter EİA açıklığı, daha iyi klinik sonlanımlar ve düşük mortalite ile ilişkilidir. Bu çalışmada, ST-segment yükselmesiz miyokard enfarktüslü NSTEMI hastalarda serum ürik asitalbümin oranı UAR ve EİA açıklığı arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntem: Toplam 430 ardışık NSTEMI hastası geriye dönük olarak değerlendirildi. Çalışma popülasyonu, PKG öncesi Miyokard Enfarktüsünde Tromboliz TIMI akış derecesi ile değerlendirilen EİA açıklığına göre 2 gruba ayrıldı. Tamamen tıkalı EİA TIMI derece 01 olarak tanımlandı ve patent EİA TIMI 23 olarak tanımlandı. Bulgular: İşlem öncesi 110 25.5 hastada EİA tıkalı olarak bulundu. EİA tıkalı olan grupta, patent olan gruba göre UAR düzeyi p0.001 daha yüksek saptandı. Regresyon analizi UAR OR:3.125, 95 GA:1.186-8.232; p0.001, sol ventrikül ejeksiyon fraksiyonu OR:0.917, 95 GA:0.885-0.951; p0.001 ve sorumlu arter çapının OR:0.917, 95 GA:0.885-0.951; p0.001 tıkalı bir EİA için bağımsız öngördürücüleri olduğunu ortaya koydu. 1.40lık bir UAR eşik değerinin, 62.7 duyarlılık ve 63.8 özgüllük ile tıkalı bir EİAyı öngördüğü bulundu AUC: 0.722, 95 GA: 0.671-0.773; p0.001. Sonuç: UAR, NSTEMIli hastalarda işlem öncesi EİA açıklığının bağımsız bir öngördürücüsüdür. Böylece, UAR acil invaziv stratejiden 2 saat fayda görecek yüksek riskli NSTEMI hastalarını belirlemede kolay erişilebilir bir parametre olabilir.

Makale detayları

Association of serum uric acid/albumin ratio with completely occluded infarct-related artery in patients with non-ST-segment elevation myocardial infarction

Yazarlar:

Orhan Karayiğit

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Journal of Medicine and Palliative Care Vol.4 Issue 1, pp.21-27

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001281432

pISSN:

2717-7505

Serum uric acid/albumin ratio

infarct-related artery

non-ST elevation myocardial infarction

serum ürik asit/albümin oranı

ST yükselmesiz miyokard enfarktüsü

enfarkt ilişkili arter

Sayı

Makale detayları

Association of serum uric acid/albumin ratio with completely occluded infarct-related artery in patients with non-ST-segment elevation myocardial infarction

Yazarlar: Orhan Karayiğit

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: Journal of Medicine and Palliative Care Vol.4 Issue 1, pp.21-27

Belge Tipi: Makale

Yayın Tarihi: 10/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001281432

pISSN: 2717-7505

Serum uric acid/albumin ratio

infarct-related artery

non-ST elevation myocardial infarction

serum ürik asit/albümin oranı

ST yükselmesiz miyokard enfarktüsü

enfarkt ilişkili arter

Sayı

Yazarlar:

Orhan Karayiğit

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Journal of Medicine and Palliative Care Vol.4 Issue 1, pp.21-27

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001281432

pISSN:

2717-7505