The Effects of Shock Waves on the Rat Fetus

Orhan YALÇIN

Makale detayları

The Effects of Shock Waves on the Rat Fetus

Yazarlar:

Orhan YALÇIN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 5, pp.499-504

Belge Tipi:

Makale

Yayın Tarihi:

4/1998

Belge Dili:

Türkçe

Document ID (Org No.):

2000758242

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

There is an ongoing controversy  regarding shock wave lithotripsy (SWL)  contraindicated during pregnancy (1, 2).  While the effects of shock waves on a variety  of cells in both clinical and experimental  studies are well documented, their effects on  the fetus remain to be clarified. In this study,  we investigated the effects of SWL on the rat  fetus. On the 8th, 11th, 14th and 17th days  of pregnancy, 100, 250 or 500 shock waves  were produced with a Multimed 2001  ELMED Systems Lithotriptor. In ongoing  pregnancy, the effects of SWL on fetuses  ranged from mild in early pregnancy to  moderate and fatal later. No viable fetuses  were determined in the latest period of  pregnancy in rats taking 500 shocks.  Histological changes were observed in the  brain, lungs and subcutaneous tissue. Fusion  and necrosis were determined in many of the  dead fetuses.  Our study demonstrates that SWL causes  fetal damage and death during the late period  of pregnancy in rats. Additional studies on  the use of SWL during pregnancy mustbe  done with later-generation lithotriptors.

 

There is an ongoing controversy  regarding shock wave lithotripsy (SWL)  contraindicated during pregnancy (1, 2).  While the effects of shock waves on a variety  of cells in both clinical and experimental  studies are well documented, their effects on  the fetus remain to be clarified. In this study,  we investigated the effects of SWL on the rat  fetus. On the 8th, 11th, 14th and 17th days  of pregnancy, 100, 250 or 500 shock waves  were produced with a Multimed 2001  ELMED Systems Lithotriptor. In ongoing  pregnancy, the effects of SWL on fetuses  ranged from mild in early pregnancy to  moderate and fatal later. No viable fetuses  were determined in the latest period of  pregnancy in rats taking 500 shocks.  Histological changes were observed in the  brain, lungs and subcutaneous tissue. Fusion  and necrosis were determined in many of the  dead fetuses.  Our study demonstrates that SWL causes  fetal damage and death during the late period  of pregnancy in rats. Additional studies on  the use of SWL during pregnancy mustbe  done with later-generation lithotriptors.

Makale detayları

The Effects of Shock Waves on the Rat Fetus

Yazarlar:

Orhan YALÇIN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 5, pp.499-504

Belge Tipi:

Makale

Yayın Tarihi:

4/1998

Belge Dili:

Türkçe

Document ID (Org No.):

2000758242

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

SWL

pregnancy

rat.

Sayı

Makale detayları

The Effects of Shock Waves on the Rat Fetus

Yazarlar: Orhan YALÇIN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 1998 Vol.28 Issue 5, pp.499-504

Belge Tipi: Makale

Yayın Tarihi: 4/1998

Belge Dili: Türkçe

Document ID (Org No.): 2000758242

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

SWL

pregnancy

rat.

Sayı

Yazarlar:

Orhan YALÇIN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 5, pp.499-504

Belge Tipi:

Makale

Yayın Tarihi:

4/1998

Belge Dili:

Türkçe

Document ID (Org No.):

2000758242

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144