Effects of treatment with hydroxychloroquine and azithromycin on the index of cardiac electrophysiological balance in patients with COVID-19: A retrospective cohort study

Songül ARAÇ; Mehmet Zülkif KARAHAN; Mehmet ÖZEL; Ramazan YİĞİT; Hasan AKKOÇ; Eşref ARAÇ

doi:https://doi.org/10.28982/josam.843042

Makale detayları

Effects of treatment with hydroxychloroquine and azithromycin on the index of cardiac electrophysiological balance in patients with COVID-19: A retrospective cohort study

Yazarlar:

Songül ARAÇ | Mehmet Zülkif KARAHAN | Mehmet ÖZEL | Ramazan YİĞİT | Hasan AKKOÇ | Eşref ARAÇ

Yayıncı:

Fatih BAŞAK

Ana Başlıklar:

Hastalıklar

Dergi:

Journal of Surgery and Medicine 2021 Vol.5 Issue 5, pp.412-416

Belge Tipi:

Makale

Yayın Tarihi:

4/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000498802

Sıklık:

Aylık

eISSN:

2602-2079

DOI:

https://doi.org/10.28982/josam.843042

Özet:

 

Background/Aim: The common cardiac toxicities of hydroxychloroquine (HCQ) and azithromycin (AZ) are not well defined in COVID-19 patients. Index of cardiac electrophysiological balance (iCEB) is used as a novel risk marker for drug-induced arrhythmias. The purpose of this study was to evaluate ventricular repolarization using iCEB and other conventional ECG parameters such as the end of electrocardiographic T wave (Tp-e) interval, Tp-e/QT ratio, and Tp-e/ heart rate-corrected QT (QTc) ratio in COVID-19 patients treated with HCQ and AZ.
Methods: This retrospective study enrolled 164 patients diagnosed with COVID-19 pneumonia in the Emergency Department (ED) and then transferred to the ward or the intensive care unit in April 2020. 
Results: A total of 164 patients with a mean age of 47 (18) years (range: 18-97 years) included 83 (50.6%) females. There were 38 and 126 patients in Groups HTQ and HTQ+AZ, respectively. On the 5th day of hospitalization, all patients’ heart rates were significantly lower (P<0.001), while QTc, QT max (V5-V6), QTmin, Tp-e (V5-V6), and iCEB values were significantly higher (P=0.01 and P<0.001 for the rest, respectively) compared to the basal values measured in the ED (P<0.001). iCEB values of the HTZ+AZ group were significantly higher than those of the HTQ group (P=0.03). iCEBc strongly positively correlated with Tp-e/QT (V5), and strongly negatively correlated with Tp-e (V5). 
Conclusion: The iCEB values were increased after HTQ and AZ treatment among COVID-19 patients, and strongly correlated with Tp-e and Tp-e/QT. iCEB is a simple, non-invasive method that can be a useful marker to evaluate ventricular repolarization in COVID-19 patients.

Makale detayları

Effects of treatment with hydroxychloroquine and azithromycin on the index of cardiac electrophysiological balance in patients with COVID-19: A retrospective cohort study

Yazarlar: Songül ARAÇ | Mehmet Zülkif KARAHAN | Mehmet ÖZEL | Ramazan YİĞİT | Hasan AKKOÇ | Eşref ARAÇ

Yayıncı: Fatih BAŞAK

Ana Başlıklar: Hastalıklar

Dergi: Journal of Surgery and Medicine 2021 Vol.5 Issue 5, pp.412-416

Belge Tipi: Makale

Yayın Tarihi: 4/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000498802

Sıklık: Aylık

eISSN: 2602-2079

DOI: https://doi.org/10.28982/josam.843042

Sayı

Yazarlar:

Songül ARAÇ | Mehmet Zülkif KARAHAN | Mehmet ÖZEL | Ramazan YİĞİT | Hasan AKKOÇ | Eşref ARAÇ

Yayıncı:

Fatih BAŞAK

Ana Başlıklar:

Hastalıklar

Dergi:

Journal of Surgery and Medicine 2021 Vol.5 Issue 5, pp.412-416

Belge Tipi:

Makale

Yayın Tarihi:

4/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000498802

Sıklık:

Aylık

eISSN:

2602-2079

DOI:

https://doi.org/10.28982/josam.843042