Benzofuran fused phenyl pyrimidine/pyrazole schiff base derivatives as bioactive agents: anticancer, antimicrobial and molecular docking studies

N.A.

Makale detayları

Benzofuran fused phenyl pyrimidine/pyrazole schiff base derivatives as bioactive agents: anticancer, antimicrobial and molecular docking studies

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1432-1442

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347561

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Benzofuran fused phenyl pyrimidinepyrazole schiff base derivatives 8a-e and 9a-e have been synthesized by a three step reaction. The structures of the synthesized compounds were established based on the analytical and spectral data. The in-vitro anticancer and antimicrobial activity of compounds against MCF-7 and HeLa cancer cell lines and microbes were studied. The compounds 8c and 9c showed significant levels of anticancer activity compared to the standard. Molecular docking studies were performed on the active site of transferase PDB ID: 4ANM with the synthesized ligands 8a-e and 9a-e for the optimization of the investigated compounds as potential cancer cell inhibitors. The antimicrobial activity was performed by using well diffusion method, compounds 8d and 9d showed maximum inhibition effect against the tested microbial pathogens, respectively.

 Benzofuran fused phenyl pyrimidinepyrazole schiff base derivatives 8a-e and 9a-e have been synthesized by a three step reaction. The structures of the synthesized compounds were established based on the analytical and spectral data. The in-vitro anticancer and antimicrobial activity of compounds against MCF-7 and HeLa cancer cell lines and microbes were studied. The compounds 8c and 9c showed significant levels of anticancer activity compared to the standard. Molecular docking studies were performed on the active site of transferase PDB ID: 4ANM with the synthesized ligands 8a-e and 9a-e for the optimization of the investigated compounds as potential cancer cell inhibitors. The antimicrobial activity was performed by using well diffusion method, compounds 8d and 9d showed maximum inhibition effect against the tested microbial pathogens, respectively.

 Benzofuran fused phenyl pyrimidinepyrazole schiff base derivatives 8a-e and 9a-e have been synthesized by a three step reaction. The structures of the synthesized compounds were established based on the analytical and spectral data. The in-vitro anticancer and antimicrobial activity of compounds against MCF-7 and HeLa cancer cell lines and microbes were studied. The compounds 8c and 9c showed significant levels of anticancer activity compared to the standard. Molecular docking studies were performed on the active site of transferase PDB ID: 4ANM with the synthesized ligands 8a-e and 9a-e for the optimization of the investigated compounds as potential cancer cell inhibitors. The antimicrobial activity was performed by using well diffusion method, compounds 8d and 9d showed maximum inhibition effect against the tested microbial pathogens, respectively.

 Benzofuran fused phenyl pyrimidinepyrazole schiff base derivatives 8a-e and 9a-e have been synthesized by a three step reaction. The structures of the synthesized compounds were established based on the analytical and spectral data. The in-vitro anticancer and antimicrobial activity of compounds against MCF-7 and HeLa cancer cell lines and microbes were studied. The compounds 8c and 9c showed significant levels of anticancer activity compared to the standard. Molecular docking studies were performed on the active site of transferase PDB ID: 4ANM with the synthesized ligands 8a-e and 9a-e for the optimization of the investigated compounds as potential cancer cell inhibitors. The antimicrobial activity was performed by using well diffusion method, compounds 8d and 9d showed maximum inhibition effect against the tested microbial pathogens, respectively.

Makale detayları

Benzofuran fused phenyl pyrimidine/pyrazole schiff base derivatives as bioactive agents: anticancer, antimicrobial and molecular docking studies

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Chemistry

Dergi: Journal of Research in Pharmacy Vol.26 Issue 5, pp.1432-1442

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347561

pISSN: 2630-6344

Benzofuran fused

pyrimidine

pyrazole

anticancer

antimicrobial

molecular docking

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1432-1442

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347561

pISSN:

2630-6344