Tractography Analysis of White Matter Pathways Associated with Speech Impairment in Parkinson's Disease

Alpen Ortug; Bahar Tekin; Hilal Melis Altıntaş

Makale detayları

Tractography Analysis of White Matter Pathways Associated with Speech Impairment in Parkinson's Disease

Yazarlar:

Alpen Ortug | Bahar Tekin | Hilal Melis Altıntaş

Yayıncı:

Dicle University

Ana Başlıklar:

Sağlık Kurumları Yönetimi | Tıp Eğitimi | Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

Dicle Tıp Dergisi Vol.52 Issue 1, pp.41-50

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001340909

pISSN:

1300-2945

Anahtar kelimeler:

Özet:

 Purpose: Parkinsons disease PD is a progressive neurodegenerative disorder affecting multiple systems. Speech disorders, stemming from motor and nonmotor deficits, affect up to 89 of PD patients. This study examines the arcuate fasciculus AF and frontal aslant tract FAT, white matter pathways linked to verbal fluency, which have not been previously assessed in PD. Methods: We included publicly available high-quality diffusion-weighted images DWI acquired with 120 gradient directions b  2500 smm² from 27 PD patients Age: 66  8, 14 M, 13 F and 26 age-, sex-, and education-matched controls Age: 64  8, 14 M, 12 F, processed using the Generalized Q-sampling Imaging GQI model DSI Studio software for white matter pathway reconstruction. The Automatic Fiber Tracking AutoTrack option in DSI Studio was used for virtual dissection of the AF and FAT. Diffusion metrics of mean diffusivity MD, radial diffusivity RD, axial diffusivity AD, fractional anisotropy FA, quantitative anisotropy QA, and track volume measures were obtained and analyzed. Results: No significant correlation was observed between quantitative anisotropy and verbal fluency measures across PD and control groups. However, male PD patients exhibited reduced left FAT volume and significantly lower QA in bilateral FAT and left AF. Microstructural changes in the FAT were observed in male PD patients, but no correlation was found between verbal fluency scores and QA. Conclusion: Our results suggest a more severe impact on the microstructure of the FAT in male PD patients compared to females.

 Purpose: Parkinsons disease PD is a progressive neurodegenerative disorder affecting multiple systems. Speech disorders, stemming from motor and nonmotor deficits, affect up to 89 of PD patients. This study examines the arcuate fasciculus AF and frontal aslant tract FAT, white matter pathways linked to verbal fluency, which have not been previously assessed in PD. Methods: We included publicly available high-quality diffusion-weighted images DWI acquired with 120 gradient directions b  2500 smm² from 27 PD patients Age: 66  8, 14 M, 13 F and 26 age-, sex-, and education-matched controls Age: 64  8, 14 M, 12 F, processed using the Generalized Q-sampling Imaging GQI model DSI Studio software for white matter pathway reconstruction. The Automatic Fiber Tracking AutoTrack option in DSI Studio was used for virtual dissection of the AF and FAT. Diffusion metrics of mean diffusivity MD, radial diffusivity RD, axial diffusivity AD, fractional anisotropy FA, quantitative anisotropy QA, and track volume measures were obtained and analyzed. Results: No significant correlation was observed between quantitative anisotropy and verbal fluency measures across PD and control groups. However, male PD patients exhibited reduced left FAT volume and significantly lower QA in bilateral FAT and left AF. Microstructural changes in the FAT were observed in male PD patients, but no correlation was found between verbal fluency scores and QA. Conclusion: Our results suggest a more severe impact on the microstructure of the FAT in male PD patients compared to females.

 Purpose: Parkinsons disease PD is a progressive neurodegenerative disorder affecting multiple systems. Speech disorders, stemming from motor and nonmotor deficits, affect up to 89 of PD patients. This study examines the arcuate fasciculus AF and frontal aslant tract FAT, white matter pathways linked to verbal fluency, which have not been previously assessed in PD. Methods: We included publicly available high-quality diffusion-weighted images DWI acquired with 120 gradient directions b  2500 smm² from 27 PD patients Age: 66  8, 14 M, 13 F and 26 age-, sex-, and education-matched controls Age: 64  8, 14 M, 12 F, processed using the Generalized Q-sampling Imaging GQI model DSI Studio software for white matter pathway reconstruction. The Automatic Fiber Tracking AutoTrack option in DSI Studio was used for virtual dissection of the AF and FAT. Diffusion metrics of mean diffusivity MD, radial diffusivity RD, axial diffusivity AD, fractional anisotropy FA, quantitative anisotropy QA, and track volume measures were obtained and analyzed. Results: No significant correlation was observed between quantitative anisotropy and verbal fluency measures across PD and control groups. However, male PD patients exhibited reduced left FAT volume and significantly lower QA in bilateral FAT and left AF. Microstructural changes in the FAT were observed in male PD patients, but no correlation was found between verbal fluency scores and QA. Conclusion: Our results suggest a more severe impact on the microstructure of the FAT in male PD patients compared to females.

 Purpose: Parkinsons disease PD is a progressive neurodegenerative disorder affecting multiple systems. Speech disorders, stemming from motor and nonmotor deficits, affect up to 89 of PD patients. This study examines the arcuate fasciculus AF and frontal aslant tract FAT, white matter pathways linked to verbal fluency, which have not been previously assessed in PD. Methods: We included publicly available high-quality diffusion-weighted images DWI acquired with 120 gradient directions b  2500 smm² from 27 PD patients Age: 66  8, 14 M, 13 F and 26 age-, sex-, and education-matched controls Age: 64  8, 14 M, 12 F, processed using the Generalized Q-sampling Imaging GQI model DSI Studio software for white matter pathway reconstruction. The Automatic Fiber Tracking AutoTrack option in DSI Studio was used for virtual dissection of the AF and FAT. Diffusion metrics of mean diffusivity MD, radial diffusivity RD, axial diffusivity AD, fractional anisotropy FA, quantitative anisotropy QA, and track volume measures were obtained and analyzed. Results: No significant correlation was observed between quantitative anisotropy and verbal fluency measures across PD and control groups. However, male PD patients exhibited reduced left FAT volume and significantly lower QA in bilateral FAT and left AF. Microstructural changes in the FAT were observed in male PD patients, but no correlation was found between verbal fluency scores and QA. Conclusion: Our results suggest a more severe impact on the microstructure of the FAT in male PD patients compared to females.

Makale detayları

Tractography Analysis of White Matter Pathways Associated with Speech Impairment in Parkinson's Disease

Yazarlar:

Alpen Ortug | Bahar Tekin | Hilal Melis Altıntaş

Yayıncı:

Dicle University

Ana Başlıklar:

Sağlık Kurumları Yönetimi | Tıp Eğitimi | Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

Dicle Tıp Dergisi Vol.52 Issue 1, pp.41-50

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001340909

pISSN:

1300-2945

diffusion MRI

parkinson

arcuate fasciculus

frontal aslant tract

speech impairment

Sayı

Makale detayları

Tractography Analysis of White Matter Pathways Associated with Speech Impairment in Parkinson's Disease

Yazarlar: Alpen Ortug | Bahar Tekin | Hilal Melis Altıntaş

Yayıncı: Dicle University

Ana Başlıklar: Sağlık Kurumları Yönetimi | Tıp Eğitimi | Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi: Dicle Tıp Dergisi Vol.52 Issue 1, pp.41-50

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001340909

pISSN: 1300-2945

diffusion MRI

parkinson

arcuate fasciculus

frontal aslant tract

speech impairment

Sayı

Yazarlar:

Alpen Ortug | Bahar Tekin | Hilal Melis Altıntaş

Yayıncı:

Dicle University

Ana Başlıklar:

Sağlık Kurumları Yönetimi | Tıp Eğitimi | Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

Dicle Tıp Dergisi Vol.52 Issue 1, pp.41-50

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001340909

pISSN:

1300-2945