Immunohistochemical evaluation of the effects of nebivolol on intimal hyperplasia following endothelial injury

İlker AKAR; Ali RAHMAN; M. Cengiz ÇOLAK; Bilal ÜSTÜNDAĞ; İbrahim Hanifi ÖZERCAN; Ayhan UYSAL

Makale detayları

Immunohistochemical evaluation of the effects of nebivolol on intimal hyperplasia following endothelial injury

Yazarlar:

İlker AKAR | Ali RAHMAN | M. Cengiz ÇOLAK | Bilal ÜSTÜNDAĞ | İbrahim Hanifi ÖZERCAN | Ayhan UYSAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 1, pp.53-63

Belge Tipi:

Makale

Yayın Tarihi:

12/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754828

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Intimal hyperplasia is a vascular remodeling process. It is a clinical problem that forms in the vascular wall as a result of smooth muscle cell migration, proliferation, and extracellular matrix accumulation. In this study we examined the immunohistochemical evaluation of the effects of nebivolol on intimal hyperplasia in damaged endothelial tissue.  Materials and methods: The study was conducted using 21 rabbits equally divided into 3 groups: control, solvent, and nebivolol. The rabbits in the control group only underwent balloon injury of the abdominal aorta. The rabbits in the solvent group and nebivolol group underwent balloon injury and were treated with solvent and nebivolol intraperitoneally during the study. At the end of the study, the abdominal aortas were harvested. The intimal and medial areas were measured and the intima/media ratios were calculated. Tissue nitric oxide levels were determined and immunohistochemical findings were evaluated.   Results: Statistically there were no differences between the control and solvent groups with respect to the intimal and medial areas, intima/media ratios, or the tissue nitric oxide (NO) levels. The neointimal thickening was significantly less in the nebivolol group than in the control and solvent groups (P < 0.001). Intima/media ratio was decreased in the nebivolol group (P < 0.001). Tissue nitric oxide levels were greater in the nebivolol group than in the control and solvent groups (P < 0.01). Immunohistochemical data in the nebivolol group were significantly lower as compared with the other groups (P < 0.05).  Conclusion: Nebivolol may be a useful agent in early restenosis after vascular reconstructive procedures.

 

Intimal hyperplasia is a vascular remodeling process. It is a clinical problem that forms in the vascular wall as a result of smooth muscle cell migration, proliferation, and extracellular matrix accumulation. In this study we examined the immunohistochemical evaluation of the effects of nebivolol on intimal hyperplasia in damaged endothelial tissue.  Materials and methods: The study was conducted using 21 rabbits equally divided into 3 groups: control, solvent, and nebivolol. The rabbits in the control group only underwent balloon injury of the abdominal aorta. The rabbits in the solvent group and nebivolol group underwent balloon injury and were treated with solvent and nebivolol intraperitoneally during the study. At the end of the study, the abdominal aortas were harvested. The intimal and medial areas were measured and the intima/media ratios were calculated. Tissue nitric oxide levels were determined and immunohistochemical findings were evaluated.   Results: Statistically there were no differences between the control and solvent groups with respect to the intimal and medial areas, intima/media ratios, or the tissue nitric oxide (NO) levels. The neointimal thickening was significantly less in the nebivolol group than in the control and solvent groups (P < 0.001). Intima/media ratio was decreased in the nebivolol group (P < 0.001). Tissue nitric oxide levels were greater in the nebivolol group than in the control and solvent groups (P < 0.01). Immunohistochemical data in the nebivolol group were significantly lower as compared with the other groups (P < 0.05).  Conclusion: Nebivolol may be a useful agent in early restenosis after vascular reconstructive procedures.

Makale detayları

Immunohistochemical evaluation of the effects of nebivolol on intimal hyperplasia following endothelial injury

Yazarlar:

İlker AKAR | Ali RAHMAN | M. Cengiz ÇOLAK | Bilal ÜSTÜNDAĞ | İbrahim Hanifi ÖZERCAN | Ayhan UYSAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 1, pp.53-63

Belge Tipi:

Makale

Yayın Tarihi:

12/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754828

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Intimal hyperplasia

nitric oxide

nebivolol

Sayı

Makale detayları

Immunohistochemical evaluation of the effects of nebivolol on intimal hyperplasia following endothelial injury

Yazarlar: İlker AKAR | Ali RAHMAN | M. Cengiz ÇOLAK | Bilal ÜSTÜNDAĞ | İbrahim Hanifi ÖZERCAN | Ayhan UYSAL

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2011 Vol.41 Issue 1, pp.53-63

Belge Tipi: Makale

Yayın Tarihi: 12/2010

Belge Dili: Türkçe

Document ID (Org No.): 2000754828

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Intimal hyperplasia

nitric oxide

nebivolol

Sayı

Yazarlar:

İlker AKAR | Ali RAHMAN | M. Cengiz ÇOLAK | Bilal ÜSTÜNDAĞ | İbrahim Hanifi ÖZERCAN | Ayhan UYSAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 1, pp.53-63

Belge Tipi:

Makale

Yayın Tarihi:

12/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754828

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144