A new marker in determining the relationship between the clinical outcomes of patients with sepsis and thyroid function tests: free triiodothyronine to free thyroxine ratio

Esra Yakışık; Çiğdem Yücel; Murat Kızılgün; Işıl Özkoçak Turan

Makale detayları

A new marker in determining the relationship between the clinical outcomes of patients with sepsis and thyroid function tests: free triiodothyronine to free thyroxine ratio

Yazarlar:

Esra Yakışık | Çiğdem Yücel | Murat Kızılgün | Işıl Özkoçak Turan

Yayıncı:

Cukurova University

Ana Başlıklar:

Yoğun Bakım

Dergi:

Cukurova Medical Journal Vol.48 Issue 3, pp.1106-1114

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286392

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: This study investigated the predictive value of thyroid hormones in septic patients. Materials and Methods: Our study was conducted in patients with sepsis in intensive care unit ICU. Free triiodothyronine fT3 and free thyroxine fT4 levels taken at the time of hospitalization and at the 48th hours were measured and the fT3  fT4 ratio was calculated. Calculated fT3 and fT4 change between first and 48th hours. Results: 192 patients with sepsis were included in the study. In non-survivor patients, first fT3 1.600.57 ngdL v.s. 2.010.41 ngdL and fT3  fT4 ratio 1.340.88 v.s. 1.790.91 were found to be significantly lower than 48th hours fT3 0.770.39 ngdL v.s. 1.870.49 ngdL and fT3  fT4 ratio 0.600.51 v.s. 1.661.21 survivors. It was found that the first fT3 levels -0.830.45 v.s. -0.230.14 and fT3  fT4 ratio -0.730.62 v.s. -0.120.11 decreased significantly more at 48th hour in non-survivors than survivors. The 48th hours fT3 level and the change in fT3 between the first and 48th hour were found to be the most significant parameters for the mortality indicator. Conclusion: fT3  fT4 ratio has predictive value for mortality in patients with sepsis in ICU. In addition, fT3 was found to be an indicator for mortality predictivity both at admission and at 48th hours.

 Purpose: This study investigated the predictive value of thyroid hormones in septic patients. Materials and Methods: Our study was conducted in patients with sepsis in intensive care unit ICU. Free triiodothyronine fT3 and free thyroxine fT4 levels taken at the time of hospitalization and at the 48th hours were measured and the fT3  fT4 ratio was calculated. Calculated fT3 and fT4 change between first and 48th hours. Results: 192 patients with sepsis were included in the study. In non-survivor patients, first fT3 1.600.57 ngdL v.s. 2.010.41 ngdL and fT3  fT4 ratio 1.340.88 v.s. 1.790.91 were found to be significantly lower than 48th hours fT3 0.770.39 ngdL v.s. 1.870.49 ngdL and fT3  fT4 ratio 0.600.51 v.s. 1.661.21 survivors. It was found that the first fT3 levels -0.830.45 v.s. -0.230.14 and fT3  fT4 ratio -0.730.62 v.s. -0.120.11 decreased significantly more at 48th hour in non-survivors than survivors. The 48th hours fT3 level and the change in fT3 between the first and 48th hour were found to be the most significant parameters for the mortality indicator. Conclusion: fT3  fT4 ratio has predictive value for mortality in patients with sepsis in ICU. In addition, fT3 was found to be an indicator for mortality predictivity both at admission and at 48th hours.

 Purpose: This study investigated the predictive value of thyroid hormones in septic patients. Materials and Methods: Our study was conducted in patients with sepsis in intensive care unit ICU. Free triiodothyronine fT3 and free thyroxine fT4 levels taken at the time of hospitalization and at the 48th hours were measured and the fT3  fT4 ratio was calculated. Calculated fT3 and fT4 change between first and 48th hours. Results: 192 patients with sepsis were included in the study. In non-survivor patients, first fT3 1.600.57 ngdL v.s. 2.010.41 ngdL and fT3  fT4 ratio 1.340.88 v.s. 1.790.91 were found to be significantly lower than 48th hours fT3 0.770.39 ngdL v.s. 1.870.49 ngdL and fT3  fT4 ratio 0.600.51 v.s. 1.661.21 survivors. It was found that the first fT3 levels -0.830.45 v.s. -0.230.14 and fT3  fT4 ratio -0.730.62 v.s. -0.120.11 decreased significantly more at 48th hour in non-survivors than survivors. The 48th hours fT3 level and the change in fT3 between the first and 48th hour were found to be the most significant parameters for the mortality indicator. Conclusion: fT3  fT4 ratio has predictive value for mortality in patients with sepsis in ICU. In addition, fT3 was found to be an indicator for mortality predictivity both at admission and at 48th hours.

 Amaç: Çalışmamızda septik hastalarda tiroid hormonlarının prediktif değerini araştırdık. Gereç ve Yöntem: Çalışmamız yoğun bakım ünitesinde YBÜ yatan sepsis hastalarında yapıldı. Hastaneye yatış anında ve 48. saatte alınan serbest triiodotironin sT3 ve serbest tiroksin sT4 düzeyleri ölçüldü ve sT3sT4 oranı hesaplandı. Birinci ve 48. saatler arasındaki sT3 ve sT4, değişikliği hesaplandı. Bulgular: Çalışmaya 192 sepsis hastası dahil edildi. Kaybedilen hastalarda birinci sT3 1.600.57 ngdL vs 2.010.41 ngdL ve sT3sT4 oranı 1.340.88 vs 1.790.91, 48. saatteki sT3 0.770.39 ngdL vs 1.870.49 ngdL ve sT3sT4 oranından 0.600.51 vs 1.661.21 yaşayanlara göre anlamlı olarak düşük bulundu. İlk sT3 düzeylerinin -0.830.45 vs -0.230.14 ve sT3sT4 oranının 48. saatte -0.730.62 vs -0.120.11 kaybedilenlerde yaşayanlarda göre anlamlı olarak daha fazla azaldığı saptandı. 48. saat sT3 düzeyi ve ilk ile 48. saat arasındaki sT3 değişiminin mortalite göstergesi için en anlamlı parametreler olduğu bulundu. Sonuç: sT3sT4 oranının YBÜdeki sepsisli hastalarda mortalite için prediktif değere sahip olduğu gösterilmiştir. Ayrıca hem yatışta hem de 48. saatteki sT3 değerleri mortalite için anlamlı öngörücü göstergeler olduğu bulundu.

Makale detayları

A new marker in determining the relationship between the clinical outcomes of patients with sepsis and thyroid function tests: free triiodothyronine to free thyroxine ratio

Yazarlar:

Esra Yakışık | Çiğdem Yücel | Murat Kızılgün | Işıl Özkoçak Turan

Yayıncı:

Cukurova University

Ana Başlıklar:

Yoğun Bakım

Dergi:

Cukurova Medical Journal Vol.48 Issue 3, pp.1106-1114

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286392

pISSN:

2602-3032

Free triiodothyronine/free thyroxine ratio

Intensive care unit

Sepsis

Thyroxine

Triiodothyronine

Serbest triiyodotironin/serbest tiroksin oranı

Yoğun bakım ünitesi

Sepsis

Tiroksin

Triiyodotironin

Sayı

Makale detayları

Yazarlar: Esra Yakışık | Çiğdem Yücel | Murat Kızılgün | Işıl Özkoçak Turan

Yayıncı: Cukurova University

Ana Başlıklar: Yoğun Bakım

Dergi: Cukurova Medical Journal Vol.48 Issue 3, pp.1106-1114

Belge Tipi: Makale

Yayın Tarihi: 9/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001286392

pISSN: 2602-3032

Sayı

Yazarlar:

Esra Yakışık | Çiğdem Yücel | Murat Kızılgün | Işıl Özkoçak Turan

Yayıncı:

Cukurova University

Ana Başlıklar:

Yoğun Bakım

Dergi:

Cukurova Medical Journal Vol.48 Issue 3, pp.1106-1114

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286392

pISSN:

2602-3032