Investigation of the relationship between oxidative stress and  SCUBE1 levels in high fat diet-induced obese rats

AKIN BODUR; Cemil KAHRAMAN; Diler Us ALTAY; Taghi Ahmadi RENDI; AHMET MENTEŞE; Ahmet ALVER

Makale detayları

Investigation of the relationship between oxidative stress and SCUBE1 levels in high fat diet-induced obese rats

Yazarlar:

AKIN BODUR | Cemil KAHRAMAN | Diler Us ALTAY | Taghi Ahmadi RENDI | AHMET MENTEŞE | Ahmet ALVER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 1, pp.196-201

Belge Tipi:

Makale

Yayın Tarihi:

1/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750952

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: This study aimed to investigate signal peptide-Cub-EGF domain-containing protein 1 (SCUBE1) levels and oxidative stress (OS) in a high fat diet (HFD)-induced obese rat model.  Materials and methods: Fourteen rats were randomly divided into two groups. Group 1, the control group, was given a standard diet (10% calories of fat) and Group 2, the obese group, was given a HFD (60% calories of fat), both for 70 days. Rats were then sacrificed and serum samples were collected. Serum glucose and triglyceride concentrations were determined using an autoanalyzer. Serum SCUBE1, adiponectin, and plasminogen activator inhibitor-1 levels were determined using an enzyme-linked immunosorbent assay. Serum malondialdehyde levels and superoxide dismutase and glutathione peroxidase enzyme activities were determined using colorimetric methods.   Results: Final body weight was higher in the obese group (P = 0.007). Serum malondialdehyde concentrations were also higher in the obese group (P = 0.021). Serum glutathione peroxidase activities were higher in the control group (P = 0.028). Serum SCUBE1 levels were also higher in the control group (P = 0.038).  Conclusion: There may be no connection between the measured OS parameters and SCUBE1. Differences in SCUBE1 levels may therefore be evaluated independently from OS in obesity.

Makale detayları

Investigation of the relationship between oxidative stress and SCUBE1 levels in high fat diet-induced obese rats

Yazarlar: AKIN BODUR | Cemil KAHRAMAN | Diler Us ALTAY | Taghi Ahmadi RENDI | AHMET MENTEŞE | Ahmet ALVER

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 1, pp.196-201

Belge Tipi: Makale

Yayın Tarihi: 1/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000750952

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

AKIN BODUR | Cemil KAHRAMAN | Diler Us ALTAY | Taghi Ahmadi RENDI | AHMET MENTEŞE | Ahmet ALVER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 1, pp.196-201

Belge Tipi:

Makale

Yayın Tarihi:

1/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750952

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144