Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels

Zehra ÖZBAŞ; Gülten GÜRDAĞ

Makale detayları

Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels

Yazarlar:

Zehra ÖZBAŞ | Gülten GÜRDAĞ

Yayıncı:

Süleyman Demirel University

Dergi:

Süleyman Demirel University Journal of Natural and Applied Sciences 2016 Vol.20 Issue 3, pp.460-467

Belge Tipi:

Makale

Yayın Tarihi:

11/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000555007

Sıklık:

Üç Yıllık

eISSN:

1308-6529

Özet:

 

In this work, the characterization and drug release behavior of 5-fluorouracil-loaded glutaraldehyde-crosslinked chitosan hydrogels have been studied. The structure of the hydrogels were investigated by Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction, also their properties were compared with those of the drug-unloaded hydrogels. The equilibrium swelling studies and drug release profiles were determined at 37°C in two different pHs (2.1 and 7.4). The results indicated that increased chitosan concentration in the hydrogel decreased the swelling and drug release values and the hydrogels released nearly the same amount of 5-fluorouracil in both acidic (~59%) and basic medium (~50%).

Makale detayları

Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels

Yazarlar: Zehra ÖZBAŞ | Gülten GÜRDAĞ

Yayıncı: Süleyman Demirel University

Dergi: Süleyman Demirel University Journal of Natural and Applied Sciences 2016 Vol.20 Issue 3, pp.460-467

Belge Tipi: Makale

Yayın Tarihi: 11/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000555007

Sıklık: Üç Yıllık

eISSN: 1308-6529

Sayı

Yazarlar:

Zehra ÖZBAŞ | Gülten GÜRDAĞ

Yayıncı:

Süleyman Demirel University

Dergi:

Süleyman Demirel University Journal of Natural and Applied Sciences 2016 Vol.20 Issue 3, pp.460-467

Belge Tipi:

Makale

Yayın Tarihi:

11/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000555007

Sıklık:

Üç Yıllık

eISSN:

1308-6529