Histopathological and Biochemical Investigation of Silymarin’s Inhibitory Effect on the Formation of Obesity Induced by High Fat Diet in Rats

İsmail Keleş; Zübeyir Huyut; Ömer Faruk Keleş; Zabit Yener

Makale detayları

Histopathological and Biochemical Investigation of Silymarin’s Inhibitory Effect on the Formation of Obesity Induced by High Fat Diet in Rats

Yazarlar:

İsmail Keleş | Zübeyir Huyut | Ömer Faruk Keleş | Zabit Yener

Yayıncı:

Kafkas University

Ana Başlıklar:

İç Hastalıkları

Dergi:

Kafkas Tıp Bilimleri Dergisi Vol.15 Issue 2, pp.123-132

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357898

pISSN:

2146-2631

Anahtar kelimeler:

Özet:

 Aim: Obesity is a health problem caused by excessive fat accumulation in the body and can lead to many health complications. Nurses play an important role in managing the care of patients struggling with obesity. This study investigated the restorative effect of silymarin on obesity induced by a high-fat diet HFD. Materials and Methods: In this study, 32 rats were randomly divided into four groups n8. Control: no action. Obesity: was fed with HFD. Silymarin: 3 mgkg silymarin was given by orogastric gavage daily. Obesitysilymarin: 3 mgkg silymarin daily was given in addition to HFD. Liver function tests and lipid profile values were measured in serum samples, and the liver was examined histopathologically. Results: Macro-microvesicular fatty changes and coagulation necrosis were observed in centrilobular hepatocytes in livers of the obesity group, while a normal histological appearance of the liver was viewed in the obesitysilymarin group. In the obesity group, ALP and LDH activities in addition to triglyceride levels were significantly higher than control, while these values in the obesitysilymarin group were similar to control. Conclusions: Silymarin largely prevented fatty liver changes and significantly restored impaired lipid profile and liver function tests in rats fed with HFD.

 Aim: Obesity is a health problem caused by excessive fat accumulation in the body and can lead to many health complications. Nurses play an important role in managing the care of patients struggling with obesity. This study investigated the restorative effect of silymarin on obesity induced by a high-fat diet HFD. Materials and Methods: In this study, 32 rats were randomly divided into four groups n8. Control: no action. Obesity: was fed with HFD. Silymarin: 3 mgkg silymarin was given by orogastric gavage daily. Obesitysilymarin: 3 mgkg silymarin daily was given in addition to HFD. Liver function tests and lipid profile values were measured in serum samples, and the liver was examined histopathologically. Results: Macro-microvesicular fatty changes and coagulation necrosis were observed in centrilobular hepatocytes in livers of the obesity group, while a normal histological appearance of the liver was viewed in the obesitysilymarin group. In the obesity group, ALP and LDH activities in addition to triglyceride levels were significantly higher than control, while these values in the obesitysilymarin group were similar to control. Conclusions: Silymarin largely prevented fatty liver changes and significantly restored impaired lipid profile and liver function tests in rats fed with HFD.

 Aim: Obesity is a health problem caused by excessive fat accumulation in the body and can lead to many health complications. Nurses play an important role in managing the care of patients struggling with obesity. This study investigated the restorative effect of silymarin on obesity induced by a high-fat diet HFD. Materials and Methods: In this study, 32 rats were randomly divided into four groups n8. Control: no action. Obesity: was fed with HFD. Silymarin: 3 mgkg silymarin was given by orogastric gavage daily. Obesitysilymarin: 3 mgkg silymarin daily was given in addition to HFD. Liver function tests and lipid profile values were measured in serum samples, and the liver was examined histopathologically. Results: Macro-microvesicular fatty changes and coagulation necrosis were observed in centrilobular hepatocytes in livers of the obesity group, while a normal histological appearance of the liver was viewed in the obesitysilymarin group. In the obesity group, ALP and LDH activities in addition to triglyceride levels were significantly higher than control, while these values in the obesitysilymarin group were similar to control. Conclusions: Silymarin largely prevented fatty liver changes and significantly restored impaired lipid profile and liver function tests in rats fed with HFD.

 Aim: Obesity is a health problem caused by excessive fat accumulation in the body and can lead to many health complications. Nurses play an important role in managing the care of patients struggling with obesity. This study investigated the restorative effect of silymarin on obesity induced by a high-fat diet HFD. Materials and Methods: In this study, 32 rats were randomly divided into four groups n8. Control: no action. Obesity: was fed with HFD. Silymarin: 3 mgkg silymarin was given by orogastric gavage daily. Obesitysilymarin: 3 mgkg silymarin daily was given in addition to HFD. Liver function tests and lipid profile values were measured in serum samples, and the liver was examined histopathologically. Results: Macro-microvesicular fatty changes and coagulation necrosis were observed in centrilobular hepatocytes in livers of the obesity group, while a normal histological appearance of the liver was viewed in the obesitysilymarin group. In the obesity group, ALP and LDH activities in addition to triglyceride levels were significantly higher than control, while these values in the obesitysilymarin group were similar to control. Conclusions: Silymarin largely prevented fatty liver changes and significantly restored impaired lipid profile and liver function tests in rats fed with HFD.

Makale detayları

Histopathological and Biochemical Investigation of Silymarin’s Inhibitory Effect on the Formation of Obesity Induced by High Fat Diet in Rats

Yazarlar:

İsmail Keleş | Zübeyir Huyut | Ömer Faruk Keleş | Zabit Yener

Yayıncı:

Kafkas University

Ana Başlıklar:

İç Hastalıkları

Dergi:

Kafkas Tıp Bilimleri Dergisi Vol.15 Issue 2, pp.123-132

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357898

pISSN:

2146-2631

liver function tests

lipid profile

histopathology

nurse care

obesity

silymarin

Sayı

Makale detayları

Histopathological and Biochemical Investigation of Silymarin’s Inhibitory Effect on the Formation of Obesity Induced by High Fat Diet in Rats

Yazarlar: İsmail Keleş | Zübeyir Huyut | Ömer Faruk Keleş | Zabit Yener

Yayıncı: Kafkas University

Ana Başlıklar: İç Hastalıkları

Dergi: Kafkas Tıp Bilimleri Dergisi Vol.15 Issue 2, pp.123-132

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001357898

pISSN: 2146-2631

liver function tests

lipid profile

histopathology

nurse care

obesity

silymarin

Sayı

Yazarlar:

İsmail Keleş | Zübeyir Huyut | Ömer Faruk Keleş | Zabit Yener

Yayıncı:

Kafkas University

Ana Başlıklar:

İç Hastalıkları

Dergi:

Kafkas Tıp Bilimleri Dergisi Vol.15 Issue 2, pp.123-132

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357898

pISSN:

2146-2631