New 8-Heterocyclic Xanthine Derivatives as Antiproliferative Agents: Synthesis and Biological Evaluation

Bilgesu Onur Sucu

Makale detayları

New 8-Heterocyclic Xanthine Derivatives as Antiproliferative Agents: Synthesis and Biological Evaluation

Yazarlar:

Bilgesu Onur Sucu

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Organic Chemical Synthesis | Biologically Active Molecules

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.11 Issue 2, pp.533-540

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001309565

pISSN:

2149-0120

Anahtar kelimeler:

Özet:

 This research focuses on the synthesis, characterization, and evaluation of the anti-cancer activity of novel 8-aryl substituted 1,3-diethylxanthine derivatives. The anti-proliferative activities of all the compounds were assessed using an MTT assay on four human cancer cell lines: breast cancer MCF7, human lung cancer A549, human brain cancers LN229, and U87. One of the derivatives of 1,3-diethylxanthine with a thiazole structure displayed strong anti-proliferative activity. 1,3-Diethyl-8-thiazol-4-yl-3,7-dihydro-1H-purine-2,6-dione 5 exhibited the strongest activity against A549, MCF7, LN229, and U87 cell lines, with IC50 values of 16.70, 78.06, 22.07, and 25.07 μM, respectively. Furthermore, the scratch assay was conducted to evaluate the effect of compound 5 on the inhibition of cell migration in A549 cells. The consistent results demonstrate that compound 5 exhibits potent anti-cancer activity, which could be further investigated to enhance its biological potential.

 This research focuses on the synthesis, characterization, and evaluation of the anti-cancer activity of novel 8-aryl substituted 1,3-diethylxanthine derivatives. The anti-proliferative activities of all the compounds were assessed using an MTT assay on four human cancer cell lines: breast cancer MCF7, human lung cancer A549, human brain cancers LN229, and U87. One of the derivatives of 1,3-diethylxanthine with a thiazole structure displayed strong anti-proliferative activity. 1,3-Diethyl-8-thiazol-4-yl-3,7-dihydro-1H-purine-2,6-dione 5 exhibited the strongest activity against A549, MCF7, LN229, and U87 cell lines, with IC50 values of 16.70, 78.06, 22.07, and 25.07 μM, respectively. Furthermore, the scratch assay was conducted to evaluate the effect of compound 5 on the inhibition of cell migration in A549 cells. The consistent results demonstrate that compound 5 exhibits potent anti-cancer activity, which could be further investigated to enhance its biological potential.

 This research focuses on the synthesis, characterization, and evaluation of the anti-cancer activity of novel 8-aryl substituted 1,3-diethylxanthine derivatives. The anti-proliferative activities of all the compounds were assessed using an MTT assay on four human cancer cell lines: breast cancer MCF7, human lung cancer A549, human brain cancers LN229, and U87. One of the derivatives of 1,3-diethylxanthine with a thiazole structure displayed strong anti-proliferative activity. 1,3-Diethyl-8-thiazol-4-yl-3,7-dihydro-1H-purine-2,6-dione 5 exhibited the strongest activity against A549, MCF7, LN229, and U87 cell lines, with IC50 values of 16.70, 78.06, 22.07, and 25.07 μM, respectively. Furthermore, the scratch assay was conducted to evaluate the effect of compound 5 on the inhibition of cell migration in A549 cells. The consistent results demonstrate that compound 5 exhibits potent anti-cancer activity, which could be further investigated to enhance its biological potential.

 This research focuses on the synthesis, characterization, and evaluation of the anti-cancer activity of novel 8-aryl substituted 1,3-diethylxanthine derivatives. The anti-proliferative activities of all the compounds were assessed using an MTT assay on four human cancer cell lines: breast cancer MCF7, human lung cancer A549, human brain cancers LN229, and U87. One of the derivatives of 1,3-diethylxanthine with a thiazole structure displayed strong anti-proliferative activity. 1,3-Diethyl-8-thiazol-4-yl-3,7-dihydro-1H-purine-2,6-dione 5 exhibited the strongest activity against A549, MCF7, LN229, and U87 cell lines, with IC50 values of 16.70, 78.06, 22.07, and 25.07 μM, respectively. Furthermore, the scratch assay was conducted to evaluate the effect of compound 5 on the inhibition of cell migration in A549 cells. The consistent results demonstrate that compound 5 exhibits potent anti-cancer activity, which could be further investigated to enhance its biological potential.

Makale detayları

New 8-Heterocyclic Xanthine Derivatives as Antiproliferative Agents: Synthesis and Biological Evaluation

Yazarlar:

Bilgesu Onur Sucu

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Organic Chemical Synthesis | Biologically Active Molecules

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.11 Issue 2, pp.533-540

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001309565

pISSN:

2149-0120

Xanthine

Heterocyclic compounds

Antiproliferative activity

Anti-cancer

MTT

Sayı

Makale detayları

New 8-Heterocyclic Xanthine Derivatives as Antiproliferative Agents: Synthesis and Biological Evaluation

Yazarlar: Bilgesu Onur Sucu

Yayıncı: Turkish Chemical Society

Ana Başlıklar: Organic Chemical Synthesis | Biologically Active Molecules

Dergi: Journal of the Turkish Chemical Society Section A: Chemistry Vol.11 Issue 2, pp.533-540

Belge Tipi: Makale

Yayın Tarihi: 5/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001309565

pISSN: 2149-0120

Xanthine

Heterocyclic compounds

Antiproliferative activity

Anti-cancer

MTT

Sayı

Yazarlar:

Bilgesu Onur Sucu

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Organic Chemical Synthesis | Biologically Active Molecules

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.11 Issue 2, pp.533-540

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001309565

pISSN:

2149-0120