Synthesis of Some New 1-Acylthiosemicarbazides and 1,2,4-Triazol-5-Thiones, and Their Analgesic and Anti-Inflammatory Activities

Yasemin DÜNDAR; Bilge ÇAKIR; Esra KÜPELİ

Makale detayları

Synthesis of Some New 1-Acylthiosemicarbazides and 1,2,4-Triazol-5-Thiones, and Their Analgesic and Anti-Inflammatory Activities

Yazarlar:

Yasemin DÜNDAR | Bilge ÇAKIR | Esra KÜPELİ

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2007 Vol.31 Issue 3, pp.301-313

Belge Tipi:

Makale

Yayın Tarihi:

2/2007

Belge Dili:

İngilizce

Document ID (Org No.):

2000728713

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

We synthesized new 1-[3-(2-oxobenzothiazolin-3-yl)propanoyl]-4-  substituted-thiosemicarbazides and their corresponding cyclized  3-[2-(2-oxobenzothiazoline-3-yl)ethyl]-4-substituted-1,2,4-triazol-5-thione  ana-logs in which position 4 of the triazole ring was substituted by  cyclohexyl, methyl, allyl, phenyl, p-methylphenyl, p-methoxyphenyl,  p-chlorophenyl, p-nitrophenyl, benzyl, and phenylethyl to screen their  analgesic and anti-inflammatory activities as well as gastric  ulceration potential in test animals.  None of the compounds, except  5a, 5e, and 5h, caused gastric lesions or bleeding.  Compound 5g  was found to have higher analgesic and anti-inflammatory activity  among the synthesized compounds.

 

We synthesized new 1-[3-(2-oxobenzothiazolin-3-yl)propanoyl]-4-  substituted-thiosemicarbazides and their corresponding cyclized  3-[2-(2-oxobenzothiazoline-3-yl)ethyl]-4-substituted-1,2,4-triazol-5-thione  ana-logs in which position 4 of the triazole ring was substituted by  cyclohexyl, methyl, allyl, phenyl, p-methylphenyl, p-methoxyphenyl,  p-chlorophenyl, p-nitrophenyl, benzyl, and phenylethyl to screen their  analgesic and anti-inflammatory activities as well as gastric  ulceration potential in test animals.  None of the compounds, except  5a, 5e, and 5h, caused gastric lesions or bleeding.  Compound 5g  was found to have higher analgesic and anti-inflammatory activity  among the synthesized compounds.

Makale detayları

Synthesis of Some New 1-Acylthiosemicarbazides and 1,2,4-Triazol-5-Thiones, and Their Analgesic and Anti-Inflammatory Activities

Yazarlar: Yasemin DÜNDAR | Bilge ÇAKIR | Esra KÜPELİ

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2007 Vol.31 Issue 3, pp.301-313

Belge Tipi: Makale

Yayın Tarihi: 2/2007

Belge Dili: İngilizce

Document ID (Org No.): 2000728713

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Yasemin DÜNDAR | Bilge ÇAKIR | Esra KÜPELİ

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2007 Vol.31 Issue 3, pp.301-313

Belge Tipi:

Makale

Yayın Tarihi:

2/2007

Belge Dili:

İngilizce

Document ID (Org No.):

2000728713

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527