The impact of diabetes on rotational atherectomy and drug-coated balloon outcomes in lower extremity chronic total occlusions

Ufuk Türkmen

Makale detayları

The impact of diabetes on rotational atherectomy and drug-coated balloon outcomes in lower extremity chronic total occlusions

Yazarlar:

Ufuk Türkmen

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kalp ve Damar Cerrahisi

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 4, pp.674-679

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001355836

pISSN:

2636-8579

Anahtar kelimeler:

Özet:

 Aims: This study aimed to evaluate the effect of combining rotational atherectomy RA and drug-coated balloon DCB angioplasty on clinical outcomes in diabetic DMG and non-diabetic NDMG patients with chronic total occlusions CTOs in the lower extremity arteries LEAs. Methods: A total of 151 patients treated between 2018 and 2022 were retrospectively analyzed. Patients were categorized as DMG n77 and NDMG n74. Outcomes such as technical success, vessel patency, re-occlusion, and ankle-brachial index ABI were compared between the groups. Results: Technical success was achieved in all patients, with a stent usage rate below 8. At 12 months, re-occlusion occurred in 13.0 of DMG and 5.4 of NDMG patients. Both groups showed a significant increase in ABI: from 0.60 to 1.10 in DMG and from 0.60 to 1.20 in NDMG. The 12-month re-occlusion-free survival rate was 87.0 in DMG and 94.6 in NDMG. Conclusion: RA combined with DCB angioplasty appears to be a safe and effective treatment strategy for CTOs in LEAs. The approach offers high technical success and favorable mid-term outcomes in both diabetic and non-diabetic patients, supporting its use in high-risk populations.

 Aims: This study aimed to evaluate the effect of combining rotational atherectomy RA and drug-coated balloon DCB angioplasty on clinical outcomes in diabetic DMG and non-diabetic NDMG patients with chronic total occlusions CTOs in the lower extremity arteries LEAs. Methods: A total of 151 patients treated between 2018 and 2022 were retrospectively analyzed. Patients were categorized as DMG n77 and NDMG n74. Outcomes such as technical success, vessel patency, re-occlusion, and ankle-brachial index ABI were compared between the groups. Results: Technical success was achieved in all patients, with a stent usage rate below 8. At 12 months, re-occlusion occurred in 13.0 of DMG and 5.4 of NDMG patients. Both groups showed a significant increase in ABI: from 0.60 to 1.10 in DMG and from 0.60 to 1.20 in NDMG. The 12-month re-occlusion-free survival rate was 87.0 in DMG and 94.6 in NDMG. Conclusion: RA combined with DCB angioplasty appears to be a safe and effective treatment strategy for CTOs in LEAs. The approach offers high technical success and favorable mid-term outcomes in both diabetic and non-diabetic patients, supporting its use in high-risk populations.

 Aims: This study aimed to evaluate the effect of combining rotational atherectomy RA and drug-coated balloon DCB angioplasty on clinical outcomes in diabetic DMG and non-diabetic NDMG patients with chronic total occlusions CTOs in the lower extremity arteries LEAs. Methods: A total of 151 patients treated between 2018 and 2022 were retrospectively analyzed. Patients were categorized as DMG n77 and NDMG n74. Outcomes such as technical success, vessel patency, re-occlusion, and ankle-brachial index ABI were compared between the groups. Results: Technical success was achieved in all patients, with a stent usage rate below 8. At 12 months, re-occlusion occurred in 13.0 of DMG and 5.4 of NDMG patients. Both groups showed a significant increase in ABI: from 0.60 to 1.10 in DMG and from 0.60 to 1.20 in NDMG. The 12-month re-occlusion-free survival rate was 87.0 in DMG and 94.6 in NDMG. Conclusion: RA combined with DCB angioplasty appears to be a safe and effective treatment strategy for CTOs in LEAs. The approach offers high technical success and favorable mid-term outcomes in both diabetic and non-diabetic patients, supporting its use in high-risk populations.

 Amaç: Bu çalışmanın amacı, rotasyonel aterektomi RA ile ilaç kaplı balon DCB kombinasyonunun, alt ekstremite arterlerinde kronik total oklüzyon CTO bulunan diyabetik ve non-diyabetik hastalardaki teknik başarı, damar açıklığı ve reoklüzyon oranları üzerindeki etkisini değerlendirmektir. Yöntemler: Ekim 2018Ekim 2022 tarihleri arasında RA  DCB uygulanan 151 hasta retrospektif olarak incelendi. Hastalar, diyabetik n77 ve non-diyabetik n74 olmak üzere iki gruba ayrıldı. Teknik başarı, reoklüzyon oranı, primer açıklık ve ayak bileği-kol indeksi ABI gibi klinik sonuçlar karşılaştırıldı. Reoklüzyonsuz sağkalım oranları Kaplan-Meier yöntemiyle analiz edildi; gruplar arası fark log-rank testi ile değerlendirildi. Bulgular: Her iki grupta da teknik başarı oranı 100, stent kullanım oranı 8 olarak saptandı. Diyabetik hastalarda 12 aylık reoklüzyon oranı 13.0, non-diyabetik hastalarda 5.4 idi p0.160. ABI değerlerinde her iki grupta da anlamlı artış gözlendi p0.001. Diyabetik grupta medyan ABI 0.60tan 1.10a, non-diyabetik grupta 0.60tan 1.20ye yükseldi. Gruplar arasında ABI değişim farkı istatistiksel olarak anlamlı değildi p0.143. Reoklüzyonsuz sağkalım oranı diyabetik grupta 87.0, non-diyabetik grupta 94.6 idi p0.48. Sonuç: RA  DCB kombinasyonu, hem diyabetik hem de non-diyabetik hastalarda yüksek teknik başarı ve düşük reoklüzyon oranları ile etkili bir tedavi yaklaşımıdır. Özellikle diyabetik grupta reoklüzyon oranları daha yüksek seyretse de, elde edilen ABI artışı tedavinin fonksiyonel etkinliğini göstermektedir. Bu çalışma, RA  DCB stratejisinin yüksek riskli popülasyonda güvenle uygulanabileceğini ve daha ileri prospektif çalışmalar için güçlü bir temel oluşturduğunu ortaya koymaktadır.

Makale detayları

The impact of diabetes on rotational atherectomy and drug-coated balloon outcomes in lower extremity chronic total occlusions

Yazarlar:

Ufuk Türkmen

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kalp ve Damar Cerrahisi

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 4, pp.674-679

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001355836

pISSN:

2636-8579

Ankle-Brachial Index

chronic total occlusion

diabetes

drug-coated balloon

peripheral artery disease

rotational atherectomyRotasyonel aterektomi

İlaç kaplı balon

Kronik total oklüzyon

Periferik arter hastalığı

Diyabet

Ayak bileği-kol indeksi

Sayı

Makale detayları

Yazarlar: Ufuk Türkmen

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Kalp ve Damar Cerrahisi

Dergi: Journal of Health Sciences and Medicine Vol.8 Issue 4, pp.674-679

Belge Tipi: Makale

Yayın Tarihi: 7/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001355836

pISSN: 2636-8579

Sayı

Yazarlar:

Ufuk Türkmen

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kalp ve Damar Cerrahisi

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 4, pp.674-679

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001355836

pISSN:

2636-8579