Low apelin levels are associated with a marked increase in risk of gestational diabetes mellitus development

Mehmet Ası Oktan

Makale detayları

Low apelin levels are associated with a marked increase in risk of gestational diabetes mellitus development

Yazarlar:

Mehmet Ası Oktan

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Gastroenterology and Hepatology

Dergi:

Developments and Experiments in Health and Medicine Vol.39 Issue 1, pp.1-10

Belge Tipi:

Makale

Yayın Tarihi:

12/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001342375

pISSN:

3062-2948

Anahtar kelimeler:

GDM, Apelin, HOMA-Ir, HbA1c

Özet:

 Background: Apelin is an adipokine which plays a role in the regulation of glucose homeostasis. Relationships between serum apelin concentrations and dysmetabolic conditions are still controversial. The aim of this study was to investigate the association of serum apelin levels with gestational diabetes mellitus GDM. Material and Methods: This study was designed as a cross-sectional research that consecutively recruited subjects with GDM n38, without GDM pregnant n41, and non-pregnant healthy women n39. Fasting blood glucose FBG, serum apelin, insulin and lipids were measured. BMI and HOMA-IR were calculated for all subjects. Logistic regression analysis was performed to determine predictors of GDM development. Results: Serum apelin levels GDM  1.99  1.36 mgml, non-GDM pregnant  2.95  1.36 mgml, non-pregnant women  2.62  1.67 mgml were significantly lower p  0.017, HOMA-IR p  0.024 and BMI p  0.001 were significantly higher in the GDM group compared with both the non-GDM and the nonpregnant women. Serum apelin levels were found to be negatively correlated with FBG r  -0.236, p  0.010, OGTT 1 h glucose r  -0.346, p  0.002  2 h glucose r  -0.248, p  0.028, HbA1c r  -0.209, p  0.023, HOMA-IR r -0.360, p  0.001 and BMI r  -0.299, p  0.001. Conclusions: Serum apelin levels were significantly lower in the GDM group as compared with both the non-GDM pregnant and the non-pregnant healthy women. Low apelin levels appear to be an independent predictor of GDM development.

 Background: Apelin is an adipokine which plays a role in the regulation of glucose homeostasis. Relationships between serum apelin concentrations and dysmetabolic conditions are still controversial. The aim of this study was to investigate the association of serum apelin levels with gestational diabetes mellitus GDM. Material and Methods: This study was designed as a cross-sectional research that consecutively recruited subjects with GDM n38, without GDM pregnant n41, and non-pregnant healthy women n39. Fasting blood glucose FBG, serum apelin, insulin and lipids were measured. BMI and HOMA-IR were calculated for all subjects. Logistic regression analysis was performed to determine predictors of GDM development. Results: Serum apelin levels GDM  1.99  1.36 mgml, non-GDM pregnant  2.95  1.36 mgml, non-pregnant women  2.62  1.67 mgml were significantly lower p  0.017, HOMA-IR p  0.024 and BMI p  0.001 were significantly higher in the GDM group compared with both the non-GDM and the nonpregnant women. Serum apelin levels were found to be negatively correlated with FBG r  -0.236, p  0.010, OGTT 1 h glucose r  -0.346, p  0.002  2 h glucose r  -0.248, p  0.028, HbA1c r  -0.209, p  0.023, HOMA-IR r -0.360, p  0.001 and BMI r  -0.299, p  0.001. Conclusions: Serum apelin levels were significantly lower in the GDM group as compared with both the non-GDM pregnant and the non-pregnant healthy women. Low apelin levels appear to be an independent predictor of GDM development.

 Background: Apelin is an adipokine which plays a role in the regulation of glucose homeostasis. Relationships between serum apelin concentrations and dysmetabolic conditions are still controversial. The aim of this study was to investigate the association of serum apelin levels with gestational diabetes mellitus GDM. Material and Methods: This study was designed as a cross-sectional research that consecutively recruited subjects with GDM n38, without GDM pregnant n41, and non-pregnant healthy women n39. Fasting blood glucose FBG, serum apelin, insulin and lipids were measured. BMI and HOMA-IR were calculated for all subjects. Logistic regression analysis was performed to determine predictors of GDM development. Results: Serum apelin levels GDM  1.99  1.36 mgml, non-GDM pregnant  2.95  1.36 mgml, non-pregnant women  2.62  1.67 mgml were significantly lower p  0.017, HOMA-IR p  0.024 and BMI p  0.001 were significantly higher in the GDM group compared with both the non-GDM and the nonpregnant women. Serum apelin levels were found to be negatively correlated with FBG r  -0.236, p  0.010, OGTT 1 h glucose r  -0.346, p  0.002  2 h glucose r  -0.248, p  0.028, HbA1c r  -0.209, p  0.023, HOMA-IR r -0.360, p  0.001 and BMI r  -0.299, p  0.001. Conclusions: Serum apelin levels were significantly lower in the GDM group as compared with both the non-GDM pregnant and the non-pregnant healthy women. Low apelin levels appear to be an independent predictor of GDM development.

 Background: Apelin is an adipokine which plays a role in the regulation of glucose homeostasis. Relationships between serum apelin concentrations and dysmetabolic conditions are still controversial. The aim of this study was to investigate the association of serum apelin levels with gestational diabetes mellitus GDM. Material and Methods: This study was designed as a cross-sectional research that consecutively recruited subjects with GDM n38, without GDM pregnant n41, and non-pregnant healthy women n39. Fasting blood glucose FBG, serum apelin, insulin and lipids were measured. BMI and HOMA-IR were calculated for all subjects. Logistic regression analysis was performed to determine predictors of GDM development. Results: Serum apelin levels GDM  1.99  1.36 mgml, non-GDM pregnant  2.95  1.36 mgml, non-pregnant women  2.62  1.67 mgml were significantly lower p  0.017, HOMA-IR p  0.024 and BMI p  0.001 were significantly higher in the GDM group compared with both the non-GDM and the nonpregnant women. Serum apelin levels were found to be negatively correlated with FBG r  -0.236, p  0.010, OGTT 1 h glucose r  -0.346, p  0.002  2 h glucose r  -0.248, p  0.028, HbA1c r  -0.209, p  0.023, HOMA-IR r -0.360, p  0.001 and BMI r  -0.299, p  0.001. Conclusions: Serum apelin levels were significantly lower in the GDM group as compared with both the non-GDM pregnant and the non-pregnant healthy women. Low apelin levels appear to be an independent predictor of GDM development.

Makale detayları

Low apelin levels are associated with a marked increase in risk of gestational diabetes mellitus development

Yazarlar: Mehmet Ası Oktan

Yayıncı: Dokuz Eylul University

Ana Başlıklar: Gastroenterology and Hepatology

Dergi: Developments and Experiments in Health and Medicine Vol.39 Issue 1, pp.1-10

Belge Tipi: Makale

Yayın Tarihi: 12/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001342375

pISSN: 3062-2948

GDM, Apelin, HOMA-Ir, HbA1c

Sayı

Yazarlar:

Mehmet Ası Oktan

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Gastroenterology and Hepatology

Dergi:

Developments and Experiments in Health and Medicine Vol.39 Issue 1, pp.1-10

Belge Tipi:

Makale

Yayın Tarihi:

12/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001342375

pISSN:

3062-2948