The Relationship Between Uric Acid/HDL Ratio and Monocyte/HDL Ratio and Glycemic Control in Male Type 2 Diabetic Patients

Semra Özkan Öztürk; Seval Müzeyyen Ecin

Makale detayları

The Relationship Between Uric Acid/HDL Ratio and Monocyte/HDL Ratio and Glycemic Control in Male Type 2 Diabetic Patients

Yazarlar:

Semra Özkan Öztürk | Seval Müzeyyen Ecin

Yayıncı:

Selcuk University

Ana Başlıklar:

Endokrinoloji | İç Hastalıkları

Dergi:

Genel Tıp Dergisi Vol.34 Issue 2, pp.207-211

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001316101

pISSN:

2602-3741

Anahtar kelimeler:

Özet:

 Background: Type 2 diabetes mellitus T2DM is a major health problem worldwide. As glycemic control worsens, the risk of both microvascular and macrovascular complications increases. . The aim of this study was to investigate the relationship between blood glucose regulation and two different parameters: uric acidHDL ratio UHR and monocyteHDL ratio MHR in male subjects with type 2 diabetes. Methods: In this retrospective study, a total of 166 male patients diagnosed with type 2 diabetes and 83 healthy adult men as a control cohort were included. Diabetic male participants were equally divided into two subgroups: the group with uncontrolled blood glucose HbA1c levels exceeding 7, n83 and the group with good glycemic control HbA1c levels at or below 7, n83. Our analysis included assessment of several serum markers, including triglyceride, high-density lipoprotein HDL, uric acid, low-density lipoprotein LDL, neutrophil, lymphocyte, monocyte, white blood cell, hemoglobin and platelet levels. In addition, uric acidHDL ratio, body mass index and monocyteHDL ratio were compared. Results: Creatinine levels were normal in all study participants and ages were similar in the groups. Triglyceride levels were significantly higher in diabetic patients compared to the healthy group P0.001. In contrast, diabetic patients had lower HDL levels than healthy subjects P0.002. Serum uric acid levels were lower in the blood glucose unregulated group than in the blood glucose well-regulated group and healthy subjects P0.001. UHR was lower in the blood glucose unregulated group compared to the blood glucose well-regulated group and healthy subjects P0.003. White blood cell, neutrophil and lymphocyte counts were higher in diabetic patients than in the healthy group P0.001, P0.001, P0.002. Platelet count and MHR values were higher in the blood glucose-unregulated group compared to the blood glucose-regulated group and healthy subjects P0.007. Conclusion: Increased MHR and decreased UHR levels are associated with uncontrolled blood glucose regulation in male patients with type 2 diabetes.

 Background: Type 2 diabetes mellitus T2DM is a major health problem worldwide. As glycemic control worsens, the risk of both microvascular and macrovascular complications increases. . The aim of this study was to investigate the relationship between blood glucose regulation and two different parameters: uric acidHDL ratio UHR and monocyteHDL ratio MHR in male subjects with type 2 diabetes. Methods: In this retrospective study, a total of 166 male patients diagnosed with type 2 diabetes and 83 healthy adult men as a control cohort were included. Diabetic male participants were equally divided into two subgroups: the group with uncontrolled blood glucose HbA1c levels exceeding 7, n83 and the group with good glycemic control HbA1c levels at or below 7, n83. Our analysis included assessment of several serum markers, including triglyceride, high-density lipoprotein HDL, uric acid, low-density lipoprotein LDL, neutrophil, lymphocyte, monocyte, white blood cell, hemoglobin and platelet levels. In addition, uric acidHDL ratio, body mass index and monocyteHDL ratio were compared. Results: Creatinine levels were normal in all study participants and ages were similar in the groups. Triglyceride levels were significantly higher in diabetic patients compared to the healthy group P0.001. In contrast, diabetic patients had lower HDL levels than healthy subjects P0.002. Serum uric acid levels were lower in the blood glucose unregulated group than in the blood glucose well-regulated group and healthy subjects P0.001. UHR was lower in the blood glucose unregulated group compared to the blood glucose well-regulated group and healthy subjects P0.003. White blood cell, neutrophil and lymphocyte counts were higher in diabetic patients than in the healthy group P0.001, P0.001, P0.002. Platelet count and MHR values were higher in the blood glucose-unregulated group compared to the blood glucose-regulated group and healthy subjects P0.007. Conclusion: Increased MHR and decreased UHR levels are associated with uncontrolled blood glucose regulation in male patients with type 2 diabetes.

 Background: Type 2 diabetes mellitus T2DM is a major health problem worldwide. As glycemic control worsens, the risk of both microvascular and macrovascular complications increases. . The aim of this study was to investigate the relationship between blood glucose regulation and two different parameters: uric acidHDL ratio UHR and monocyteHDL ratio MHR in male subjects with type 2 diabetes. Methods: In this retrospective study, a total of 166 male patients diagnosed with type 2 diabetes and 83 healthy adult men as a control cohort were included. Diabetic male participants were equally divided into two subgroups: the group with uncontrolled blood glucose HbA1c levels exceeding 7, n83 and the group with good glycemic control HbA1c levels at or below 7, n83. Our analysis included assessment of several serum markers, including triglyceride, high-density lipoprotein HDL, uric acid, low-density lipoprotein LDL, neutrophil, lymphocyte, monocyte, white blood cell, hemoglobin and platelet levels. In addition, uric acidHDL ratio, body mass index and monocyteHDL ratio were compared. Results: Creatinine levels were normal in all study participants and ages were similar in the groups. Triglyceride levels were significantly higher in diabetic patients compared to the healthy group P0.001. In contrast, diabetic patients had lower HDL levels than healthy subjects P0.002. Serum uric acid levels were lower in the blood glucose unregulated group than in the blood glucose well-regulated group and healthy subjects P0.001. UHR was lower in the blood glucose unregulated group compared to the blood glucose well-regulated group and healthy subjects P0.003. White blood cell, neutrophil and lymphocyte counts were higher in diabetic patients than in the healthy group P0.001, P0.001, P0.002. Platelet count and MHR values were higher in the blood glucose-unregulated group compared to the blood glucose-regulated group and healthy subjects P0.007. Conclusion: Increased MHR and decreased UHR levels are associated with uncontrolled blood glucose regulation in male patients with type 2 diabetes.

 Amaç: Tip 2 diabetes mellitus T2DM dünya çapında önemli bir sağlık sorunudur Glisemik kontrol kötüleştikçe, hem mikrovasküler hem de makrovasküler komplikasyon riski artar. Bu çalışmada amacımız, tip 2 diyabet tanısı almış erkek bireylerde kan şekeri regülasyonu ile iki farklı parametre arasındaki ilişkiyi araştırmaktır: ürik asitHDL oranı UHR ve monositHDL oranı MHR. Yöntem: Bu retrospektif araştırmada, tip 2 diyabet tanısı konmuş toplam 166 erkek hasta ve kontrol kohortu olarak 83 sağlıklı yetişkin erkek çalışmaya dahil edilmiştir. Diyabetik erkek katılımcılar eşit olarak iki alt gruba ayrıldı: kan şekeri kontrol altında olmayan grup 7yi aşan HbA1c seviyeleri, n83 ve iyi glisemik kontrolü olan grup 7 veya altında HbA1c seviyeleri, n83. Analizimiz, yüksek yoğunluklu lipoprotein HDL, trigliserit , düşük yoğunluklu lipoprotein LDL, ürik asit, nötrofil, lenfosit, monosit, beyaz kan hücresi, hemoglobin ve trombosit seviyeleri dahil olmak üzere çeşitli serum belirteçlerinin değerlendirilmesini kapsamıştır. Ayrıca, UHR, vücut kitle indeksi ve MHR karşılaştırılmıştır. Bulgular: Çalışma kapsamında tüm katılımcıların kreatinin düzeyleri normaldi. gruplarda yaşlar benzerdi. Trigliserid düzeyleri diyabetik hastalarda sağlıklı grubuna kıyasla belirgin şekilde yüksekti P0.001. Buna karşılık, diyabetik hastaların HDL seviyeleri sağlıklı bireylerden daha düşüktü P0.002. Serum ürik asit düzeyleri, kan şekeri düzenlenmemiş grupta, kan şekeri iyi düzenlenmiş gruptan ve sağlıklı bireylerden daha düşüktü. P0.001. Kan şekeri düzenlenmemiş grupta, kan şekeri iyi düzenlenmiş gruba ve sağlıklı bireylere kıyasla UHR daha düşüktü P0.003. Beyaz kan hücreleri, nötrofil ve lenfosit sayıları diyabetik hastalarda sağlıklı gruptan yüksek bulundu P0.001, P0.001 ve P0.002. Trombosit sayısı ve MHR değerleri kan şekeri regüle olmayan grupta kan şekeri regüle edilen gruba ve sağlıklı bireylere kıyasla daha yüksek bulunmuştur P0.007. Sonuç: Tip 2 diyabetli erkek hastalarda artmış MHR ve azalmış UHR düzeyleri kontrolsüz kan şekeri regülasyonu ile ilişkilidir.

Makale detayları

The Relationship Between Uric Acid/HDL Ratio and Monocyte/HDL Ratio and Glycemic Control in Male Type 2 Diabetic Patients

Yazarlar:

Semra Özkan Öztürk | Seval Müzeyyen Ecin

Yayıncı:

Selcuk University

Ana Başlıklar:

Endokrinoloji | İç Hastalıkları

Dergi:

Genel Tıp Dergisi Vol.34 Issue 2, pp.207-211

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001316101

pISSN:

2602-3741

Type 2 diabetes mellitus

Uric acid/HDL ratio

Monocyte/HDL ratio

HbA1Cip 2 diyabet

Ürik asit/HDL oranı

Monosit/HDL oranı

HbA1C

Sayı

Makale detayları

Yazarlar: Semra Özkan Öztürk | Seval Müzeyyen Ecin

Yayıncı: Selcuk University

Ana Başlıklar: Endokrinoloji | İç Hastalıkları

Dergi: Genel Tıp Dergisi Vol.34 Issue 2, pp.207-211

Belge Tipi: Makale

Yayın Tarihi: 4/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001316101

pISSN: 2602-3741

Sayı

Yazarlar:

Semra Özkan Öztürk | Seval Müzeyyen Ecin

Yayıncı:

Selcuk University

Ana Başlıklar:

Endokrinoloji | İç Hastalıkları

Dergi:

Genel Tıp Dergisi Vol.34 Issue 2, pp.207-211

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001316101

pISSN:

2602-3741