Phytochemical screening and radical scavenging activity of green coffee bean extract: Multiple-protective efficacy against Bisphenol A

Burhan DURHAN; Emine YALÇIN; Kültigin ÇAVUŞOĞLU; Ali ACAR

Makale detayları

Phytochemical screening and radical scavenging activity of green coffee bean extract: Multiple-protective efficacy against Bisphenol A

Yazarlar:

Burhan DURHAN | Emine YALÇIN | Kültigin ÇAVUŞOĞLU | Ali ACAR

Yayıncı:

Tokat Gaziosmanpasa University

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Journal of Gaziosmanpasa Scientific Research 2021 Vol.10 Issue 3, pp.256-275

Belge Tipi:

Makale

Yayın Tarihi:

12/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000448009

Sıklık:

Üç Yıllık

eISSN:

2146-8168

pISSN:

2146-8168

Özet:

 

In this study, phytochemical characterization, radical scavenging activity and the protective role of green coffee bean extract (Gcbe) against Bisphenol-A (BpA) were evaluated. In phytochemical analysis total phenolic, flavonoid and tannin contents were investigated and major components were determined by HPLC. The amerolative effect of Gcbe against BpA-induced toxicity were studied in albino mice. For this purpose, mice were separated into six groups which treated with tap-water, BpA and two doses of Gcbe. To determine BpA toxicity and the protective role of Gcbe, changes in some biochemical parameters, micronucleus (MN) frequency and DNA fragmentation were investigated. As a result, the phenolic compounds in the Gcbe content were more intense than the other components. In BpA-treated group, serum parameters increased and the antioxidant/oxidant dynamics were impaired. Gcbe treatment decreased the induced serum parameters and caused an improvement in antioxidant-oxidant dynamics and also a decrease in the DNA-tail percentage and MN frequency. 

Bisphenol A, Comet, Green coffee bean extract, Phytochemical characterization, Radical scavenging activity.

 

In this study, phytochemical characterization, radical scavenging activity and the protective role of green coffee bean extract (Gcbe) against Bisphenol-A (BpA) were evaluated. In phytochemical analysis total phenolic, flavonoid and tannin contents were investigated and major components were determined by HPLC. The amerolative effect of Gcbe against BpA-induced toxicity were studied in albino mice. For this purpose, mice were separated into six groups which treated with tap-water, BpA and two doses of Gcbe. To determine BpA toxicity and the protective role of Gcbe, changes in some biochemical parameters, micronucleus (MN) frequency and DNA fragmentation were investigated. As a result, the phenolic compounds in the Gcbe content were more intense than the other components. In BpA-treated group, serum parameters increased and the antioxidant/oxidant dynamics were impaired. Gcbe treatment decreased the induced serum parameters and caused an improvement in antioxidant-oxidant dynamics and also a decrease in the DNA-tail percentage and MN frequency.

Makale detayları

Phytochemical screening and radical scavenging activity of green coffee bean extract: Multiple-protective efficacy against Bisphenol A

Yazarlar: Burhan DURHAN | Emine YALÇIN | Kültigin ÇAVUŞOĞLU | Ali ACAR

Yayıncı: Tokat Gaziosmanpasa University

Ana Başlıklar: Uygulamalı fizik

Dergi: Journal of Gaziosmanpasa Scientific Research 2021 Vol.10 Issue 3, pp.256-275

Belge Tipi: Makale

Yayın Tarihi: 12/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000448009

Sıklık: Üç Yıllık

eISSN: 2146-8168

pISSN: 2146-8168

Sayı

Yazarlar:

Burhan DURHAN | Emine YALÇIN | Kültigin ÇAVUŞOĞLU | Ali ACAR

Yayıncı:

Tokat Gaziosmanpasa University

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Journal of Gaziosmanpasa Scientific Research 2021 Vol.10 Issue 3, pp.256-275

Belge Tipi:

Makale

Yayın Tarihi:

12/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000448009

Sıklık:

Üç Yıllık

eISSN:

2146-8168

pISSN:

2146-8168