Synthesis of Pyridine-Based Imine Compounds and Molecular Docking Studies Against Dopamine D2 Receptors

Sertan Aytaç

Makale detayları

Synthesis of Pyridine-Based Imine Compounds and Molecular Docking Studies Against Dopamine D2 Receptors

Yazarlar:

Sertan Aytaç

Yayıncı:

Hitit University

Ana Başlıklar:

Food Technology

Dergi:

Hittite Journal of Science and Engineering Vol.10 Issue 2, pp.161-165

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292979

pISSN:

2148-4171

Anahtar kelimeler:

Özet:

 In this study, new pyridine-based imine compounds 8-10 were synthesized and docking studies of these compounds against D2 Dopamine receptor 6CM4 were performed. The structures of these compounds, which were synthesized using the microwave method, were determined by 1H-NMR, 13C-NMR and elemental analysis techniques. The binding energy values vary range from -6.79 to -7.07 kcalmol with D2 Dopamine ReceptorPDB: 6MC4. Compound 10 -7.07 kcal mol-1 showed better binding energy than 9 -6.95 kcal mol-1 and 8 -6.79 kcalmol.

 In this study, new pyridine-based imine compounds 8-10 were synthesized and docking studies of these compounds against D2 Dopamine receptor 6CM4 were performed. The structures of these compounds, which were synthesized using the microwave method, were determined by 1H-NMR, 13C-NMR and elemental analysis techniques. The binding energy values vary range from -6.79 to -7.07 kcalmol with D2 Dopamine ReceptorPDB: 6MC4. Compound 10 -7.07 kcal mol-1 showed better binding energy than 9 -6.95 kcal mol-1 and 8 -6.79 kcalmol.

 In this study, new pyridine-based imine compounds 8-10 were synthesized and docking studies of these compounds against D2 Dopamine receptor 6CM4 were performed. The structures of these compounds, which were synthesized using the microwave method, were determined by 1H-NMR, 13C-NMR and elemental analysis techniques. The binding energy values vary range from -6.79 to -7.07 kcalmol with D2 Dopamine ReceptorPDB: 6MC4. Compound 10 -7.07 kcal mol-1 showed better binding energy than 9 -6.95 kcal mol-1 and 8 -6.79 kcalmol.

 In this study, new pyridine-based imine compounds 8-10 were synthesized and docking studies of these compounds against D2 Dopamine receptor 6CM4 were performed. The structures of these compounds, which were synthesized using the microwave method, were determined by 1H-NMR, 13C-NMR and elemental analysis techniques. The binding energy values vary range from -6.79 to -7.07 kcalmol with D2 Dopamine ReceptorPDB: 6MC4. Compound 10 -7.07 kcal mol-1 showed better binding energy than 9 -6.95 kcal mol-1 and 8 -6.79 kcalmol.

Makale detayları

Synthesis of Pyridine-Based Imine Compounds and Molecular Docking Studies Against Dopamine D2 Receptors

Yazarlar:

Sertan Aytaç

Yayıncı:

Hitit University

Ana Başlıklar:

Food Technology

Dergi:

Hittite Journal of Science and Engineering Vol.10 Issue 2, pp.161-165

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292979

pISSN:

2148-4171

β-Phenylethylamine

Dopamine

Imine

D2 receptor

Molecular dockingβ-Phenylethylamine

Dopamine

Imine

D2 receptor

Molecular docking

Sayı

Makale detayları

Yazarlar: Sertan Aytaç

Yayıncı: Hitit University

Ana Başlıklar: Food Technology

Dergi: Hittite Journal of Science and Engineering Vol.10 Issue 2, pp.161-165

Belge Tipi: Makale

Yayın Tarihi: 6/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001292979

pISSN: 2148-4171

Sayı

Yazarlar:

Sertan Aytaç

Yayıncı:

Hitit University

Ana Başlıklar:

Food Technology

Dergi:

Hittite Journal of Science and Engineering Vol.10 Issue 2, pp.161-165

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292979

pISSN:

2148-4171