The role of elevated monocyte and high-density lipoprotein cholesterol ratio in endothelial dysfunction and cardiovascular risk in acromegaly patients

Mustafa Aydemir; Ramazan Sarı

Makale detayları

The role of elevated monocyte and high-density lipoprotein cholesterol ratio in endothelial dysfunction and cardiovascular risk in acromegaly patients

Yazarlar:

Mustafa Aydemir | Ramazan Sarı

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Endokrinoloji

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 3, pp.435-440

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349473

pISSN:

2636-8579

Anahtar kelimeler:

Özet:

 Aims: This study aimed to investigate the role of the monocyte-to-high-density lipoprotein ratio MHR as an indicator of endothelial dysfunction and cardiovascular risk in patients with acromegaly. Methods: The study group consisted of 125 patients diagnosed with acromegaly, while the control group included 123 healthy individuals who visited the endocrine clinic due to pituitary incidentaloma but had no acromegaly diagnosis. Medical and laboratory records of all participants were reviewed retrospectively. Results: The average MHR in patients with acromegaly was found to be statistically significantly higher than that in the healthy control group. In the acromegaly group, systolic blood pressure, glucose, HbA1c, lipids total cholesterol, LDL, triglycerides, sedimentation rate, CRP, and neutrophils were significantly higher to the control group. The optimal MHR cutoff for acromegaly was 12.01, with 85.1 sensitivity, 85 specificity, and an AUC of 0.64. Conclusion: MHR, a potential biomarker considered an indicator of inflammation, was significantly higher in patients with acromegaly compared to the healthy control group. This finding suggests that MHR may serve as a useful marker for assessing cardiovascular risk and endothelial dysfunction in patients with acromegaly.

 Aims: This study aimed to investigate the role of the monocyte-to-high-density lipoprotein ratio MHR as an indicator of endothelial dysfunction and cardiovascular risk in patients with acromegaly. Methods: The study group consisted of 125 patients diagnosed with acromegaly, while the control group included 123 healthy individuals who visited the endocrine clinic due to pituitary incidentaloma but had no acromegaly diagnosis. Medical and laboratory records of all participants were reviewed retrospectively. Results: The average MHR in patients with acromegaly was found to be statistically significantly higher than that in the healthy control group. In the acromegaly group, systolic blood pressure, glucose, HbA1c, lipids total cholesterol, LDL, triglycerides, sedimentation rate, CRP, and neutrophils were significantly higher to the control group. The optimal MHR cutoff for acromegaly was 12.01, with 85.1 sensitivity, 85 specificity, and an AUC of 0.64. Conclusion: MHR, a potential biomarker considered an indicator of inflammation, was significantly higher in patients with acromegaly compared to the healthy control group. This finding suggests that MHR may serve as a useful marker for assessing cardiovascular risk and endothelial dysfunction in patients with acromegaly.

 Aims: This study aimed to investigate the role of the monocyte-to-high-density lipoprotein ratio MHR as an indicator of endothelial dysfunction and cardiovascular risk in patients with acromegaly. Methods: The study group consisted of 125 patients diagnosed with acromegaly, while the control group included 123 healthy individuals who visited the endocrine clinic due to pituitary incidentaloma but had no acromegaly diagnosis. Medical and laboratory records of all participants were reviewed retrospectively. Results: The average MHR in patients with acromegaly was found to be statistically significantly higher than that in the healthy control group. In the acromegaly group, systolic blood pressure, glucose, HbA1c, lipids total cholesterol, LDL, triglycerides, sedimentation rate, CRP, and neutrophils were significantly higher to the control group. The optimal MHR cutoff for acromegaly was 12.01, with 85.1 sensitivity, 85 specificity, and an AUC of 0.64. Conclusion: MHR, a potential biomarker considered an indicator of inflammation, was significantly higher in patients with acromegaly compared to the healthy control group. This finding suggests that MHR may serve as a useful marker for assessing cardiovascular risk and endothelial dysfunction in patients with acromegaly.

 Amaç: Bu çalışma, akromegali hastalarında monosityüksek dansiteli lipoprotein oranının MHR endotel disfonksiyonu ve kardiyovasküler risk üzerindeki rolünü incelemeyi amaçlamıştır. Yöntem: Çalışma grubu, akromegali tanısı almış 125 hastadan, kontrol grubu ise hipofizer insidentoloma nedeniyle endokrin kliniğine başvuran ancak akromegali tanısı olmayan 123 sağlıklı bireyden oluşmuştur. Tüm katılımcıların medikal ve laboratuvar kayıtları retrospektif olarak incelenmiştir. Bulgular: Akromegali hastalarında ortalama MHR, sağlıklı kontrol grubuna kıyasla istatistiksel olarak anlamlı derecede yüksek bulunmuştur. Akromegali grubunda, sistolik kan basıncı, glikoz, HbA1c, lipitler toplam kolesterol, LDL, trigliseritler, sedimentasyon hızı, CRP ve nötrofiller kontrol grubuna kıyasla anlamlı olarak daha yüksekti. Akromegali için optimal MHR cutoff değeri 12.01 olup, 85,1 sensitivity, 85 specificity ve 0.64 AUC değerine sahipti. Sonuç: Enflamasyonun bir göstergesi olarak kabul edilen potansiyel bir biyobelirteç olan MHR, akromegali hastalarında sağlıklı gruba kıyasla anlamlı derecede yüksek bulunmuştur. Bu durum, MHRnin akromegali hastalarında kardiyovasküler risk ve endotel disfonksiyonunu değerlendirmede yararlı bir gösterge olabileceğini düşündürmektedir.

Makale detayları

The role of elevated monocyte and high-density lipoprotein cholesterol ratio in endothelial dysfunction and cardiovascular risk in acromegaly patients

Yazarlar:

Mustafa Aydemir | Ramazan Sarı

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Endokrinoloji

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 3, pp.435-440

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349473

pISSN:

2636-8579

Acromegaly

monocyte to HDL cholesterol ratio

cardiovascular risk

cardiovascular markersAkromegali

Monosit / HDL Kolesterol Oranı

Kardiyovasküler Risk

Kardiyovasküler Belirteçler

Sayı

Makale detayları

Yazarlar: Mustafa Aydemir | Ramazan Sarı

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Endokrinoloji

Dergi: Journal of Health Sciences and Medicine Vol.8 Issue 3, pp.435-440

Belge Tipi: Makale

Yayın Tarihi: 5/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001349473

pISSN: 2636-8579

Sayı

Yazarlar:

Mustafa Aydemir | Ramazan Sarı

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Endokrinoloji

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 3, pp.435-440

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001349473

pISSN:

2636-8579