Abstracts of speaks in 7th World Congress of Oxidative Stress, Calcium Signaling and TRP Channels

Anonymous ANONYMOUS

Makale detayları

Abstracts of speaks in 7th World Congress of Oxidative Stress, Calcium Signaling and TRP Channels

Yazarlar:

Anonymous ANONYMOUS

Yayıncı:

Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Dergi:

Journal of Cellular Neuroscience and Oxidative Stress 2018 Vol.10 Issue 2, pp.661-682

Belge Tipi:

Makale

Yayın Tarihi:

5/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000708887

Sıklık:

Üç Yıllık

eISSN:

2149-7222

Özet:

 


In most eukaryotic cells, calcium signaling occurs through an interacting combination of intracellular calcium release and entry of calcium across the plasma membrane. Although various mechanisms can subtend these processes, the most widely encountered mechanisms are intracellular calcium release via the inositol trisphosphate receptor, and entry of calcium through store-operated channels. Storeoperated calcium entry, as the name implies, involves activation of plasma membrane channels in response to a loss of calcium from intracellular endoplasmic (or sarcoplasmic) reticulum stores. The calcium level in the endoplasmic reticulum is sensed by either of two transmembrane calcium-binding proteins, STIM1 or STIM2. When calcium dissociates from the luminal binding site on STIM1 or 2, the protein aggregates and translocates to sites of close apposition of endoplasmic reticulum and plasma membranes. There, STIM recruits and binds hexameric calcium channels composed of Orai1 subunits (or possibly Orai2 or Orai3). This results in activation of the channels and accelerated entry of calcium into the cytoplasm.

.

Makale detayları

Abstracts of speaks in 7th World Congress of Oxidative Stress, Calcium Signaling and TRP Channels

Yazarlar: Anonymous ANONYMOUS

Yayıncı: Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Dergi: Journal of Cellular Neuroscience and Oxidative Stress 2018 Vol.10 Issue 2, pp.661-682

Belge Tipi: Makale

Yayın Tarihi: 5/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000708887

Sıklık: Üç Yıllık

eISSN: 2149-7222

Sayı

Yazarlar:

Anonymous ANONYMOUS

Yayıncı:

Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Dergi:

Journal of Cellular Neuroscience and Oxidative Stress 2018 Vol.10 Issue 2, pp.661-682

Belge Tipi:

Makale

Yayın Tarihi:

5/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000708887

Sıklık:

Üç Yıllık

eISSN:

2149-7222