The effects of iloprost and alprostadil on ischemia-reperfusion injury in preventing inflammation, tissue degeneration, and apoptosis in rat skeletal muscle

Elif GÜNEYSU; Atacan Emre KOÇMAN; Orhan ÖZATİK; Cengiz OVALI; Betül CAN; İbrahim Özkan ALATAŞ; MUSTAFA BEHÇET SEVİN

Makale detayları

The effects of iloprost and alprostadil on ischemia-reperfusion injury in preventing inflammation, tissue degeneration, and apoptosis in rat skeletal muscle

Yazarlar:

Elif GÜNEYSU | Atacan Emre KOÇMAN | Orhan ÖZATİK | Cengiz OVALI | Betül CAN | İbrahim Özkan ALATAŞ | MUSTAFA BEHÇET SEVİN

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 3, pp.1028-1036

Belge Tipi:

Makale

Yayın Tarihi:

5/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000751369

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: The protective effects of prostaglandin (PG) analogs on ischemia-reperfusion (I/R) have been well documented; however, comparative studies are lacking. The aim of the present study was to determine whether iloprost or alprostadil is more effective in preventing muscle I/R injury.  Materials and methods: Thirty-two rats were divided into four groups (n = 8): sham, control, IL (I/R + iloprost), and AL (I/R + alprostadil). I/R was induced by a tourniquet in the hindlimb for 3 h/3 h. The IL and AL groups received iloprost (0.5 ng kg-1 min-1) and alprostadil (0.05 μg kg-1 min-1) during reperfusion, respectively. After 6 h, blood and muscles were collected for analyses.  Results: Serum TNF-α and IL-1β levels were decreased in the IL and AL groups compared with the control group (P < 0.05), whereas IL-6 levels did not change significantly. Tissue malondialdehyde levels were significantly lower in the IL and AL groups (P < 0.05). Tissue catalase levels showed no difference. The histological damage scores and apoptosis scores were both significantly decreased in the IL and AL groups compared with the control group (P< 0.05).  Conclusion: The present study indicated that iloprost and alprostadil attenuated I/R injury in skeletal muscle. However, no comparable difference was evident regarding the efficacies of either PG analog.

Makale detayları

The effects of iloprost and alprostadil on ischemia-reperfusion injury in preventing inflammation, tissue degeneration, and apoptosis in rat skeletal muscle

Yazarlar: Elif GÜNEYSU | Atacan Emre KOÇMAN | Orhan ÖZATİK | Cengiz OVALI | Betül CAN | İbrahim Özkan ALATAŞ | MUSTAFA BEHÇET SEVİN

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2017 Vol.47 Issue 3, pp.1028-1036

Belge Tipi: Makale

Yayın Tarihi: 5/2017

Belge Dili: İngilizce

Document ID (Org No.): 2000751369

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Elif GÜNEYSU | Atacan Emre KOÇMAN | Orhan ÖZATİK | Cengiz OVALI | Betül CAN | İbrahim Özkan ALATAŞ | MUSTAFA BEHÇET SEVİN

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 3, pp.1028-1036

Belge Tipi:

Makale

Yayın Tarihi:

5/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000751369

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144