Investigation of Predictive Potential of TPH1 Common Polymorphism in Idiopathic Scoliosis

Svetla Todorova NİKOLOVA; Vasil Tsankov YABLANSKİ; Evgeni Nedev VLAEV; Alexey Slavkov SAVOV; İvo Marinov KREMENSKY

doi:https://doi.org/10.5799/jcei.328607

Makale detayları

Investigation of Predictive Potential of TPH1 Common Polymorphism in Idiopathic Scoliosis

Yazarlar:

Svetla Todorova NİKOLOVA | Vasil Tsankov YABLANSKİ | Evgeni Nedev VLAEV | Alexey Slavkov SAVOV | İvo Marinov KREMENSKY

Yayıncı:

Sağlık Araştırmaları Derneği

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Clinical and Experimental Investigations 2016 Vol.7 Issue 3, pp.216-221

Belge Tipi:

Makale

Yayın Tarihi:

8/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000833187

Sıklık:

Üç Aylık

eISSN:

1309-6621

pISSN:

1309-8578

DOI:

https://doi.org/10.5799/jcei.328607

Özet:

 


Objectives: The association studies are the predominant type of studies on genetics of the common diseases. The
present case-control study aims to investigate the association between the promoter polymorphism TPH1 (rs10488682
T/A) and the predisposition to idiopathic scoliosis (IS) in a Bulgarian population sample.
Methods: A total of 105 patients and 210 healthy gender-matched controls were included. The TPH1 promoter polymorphism
was genotyped by amplification followed by restriction. The statistical analysis was performed by the Pearson's
chi-squared test and the Fisher’s exact test. A value of p less than 0.05 was considered statistically significant.
Results: The results indicated that TPH1 (rs10488682) is not associated with the susceptibility to IS, the onset of the
disease, the family history or the gender. Based on these preliminary results, the examined polymorphic variant could
not be considered as a predisposing factor for IS in Bulgarian patients.
Conclusions: Much larger case-control studies will be needed to examine the role of this TPH1 functional genetic variant
in the etiology and pathogenesis of IS in Caucasian population. The identification of molecular markers for IS could
be useful for early detection of the predisposition among the relatives and for more accurate prognosis of the risk for a
rapid progression of the curve in the affected children. 

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Makale detayları

Investigation of Predictive Potential of TPH1 Common Polymorphism in Idiopathic Scoliosis

Yazarlar: Svetla Todorova NİKOLOVA | Vasil Tsankov YABLANSKİ | Evgeni Nedev VLAEV | Alexey Slavkov SAVOV | İvo Marinov KREMENSKY

Yayıncı: Sağlık Araştırmaları Derneği

Ana Başlıklar: Sağlık teşvikleri

Dergi: Journal of Clinical and Experimental Investigations 2016 Vol.7 Issue 3, pp.216-221

Belge Tipi: Makale

Yayın Tarihi: 8/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000833187

Sıklık: Üç Aylık

eISSN: 1309-6621

pISSN: 1309-8578

DOI: https://doi.org/10.5799/jcei.328607

Sayı

Yazarlar:

Svetla Todorova NİKOLOVA | Vasil Tsankov YABLANSKİ | Evgeni Nedev VLAEV | Alexey Slavkov SAVOV | İvo Marinov KREMENSKY

Yayıncı:

Sağlık Araştırmaları Derneği

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Clinical and Experimental Investigations 2016 Vol.7 Issue 3, pp.216-221

Belge Tipi:

Makale

Yayın Tarihi:

8/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000833187

Sıklık:

Üç Aylık

eISSN:

1309-6621

pISSN:

1309-8578

DOI:

https://doi.org/10.5799/jcei.328607