Synthesis and characterisations of some new 2,4-dihydro-[1,2,4]-triazol-3-one derivatives and X-ray crystal structures of 4-(3-phenylallylideneamino)-5- thiophen-2-yl-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Kemal SANCAK; Yasemin ÜNVER; Canan KAZAK; Esra DÜĞDÜ; Burcu ARSLAN

doi:https://doi.org/10.3906/vet-1110-43

Makale detayları

Synthesis and characterisations of some new 2,4-dihydro-[1,2,4]-triazol-3-one derivatives and X-ray crystal structures of 4-(3-phenylallylideneamino)-5- thiophen-2-yl-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Yazarlar:

Kemal SANCAK | Yasemin ÜNVER | Canan KAZAK | Esra DÜĞDÜ | Burcu ARSLAN

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2010 Vol.34 Issue 5, pp.771-780

Belge Tipi:

Makale

Yayın Tarihi:

4/2010

Belge Dili:

İngilizce

Document ID (Org No.):

2000727987

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/vet-1110-43

Özet:

 

Compounds 2 were synthesised via the reaction of  4-amino-5-thiophen-2-yl-methyl-2,4-dihydro-[1,2,4]-triazol-3-one (1)  with aldehydes.  Compounds 3 and 4 were obtained from compounds 2 with  bromo acetophenone and ethyl bromoacetate, respectively.  The  synthesis of compounds 2, 3, and 4 and crystal structure of compound  2a are being reported.  The molecular structures were identified by  IR, 1H-NMR, 13C-NMR, MS, and elemental analyses.  Compound 2a  crystallises in the monoclinic P 21/n space group, with a = 6.565(5)  Å, b = 18.278(5) Å, c = 13.8166(18) Å, b = 96.227(5)°, V =  1553.6(14) Å3, Z = 4.  The newly compounds synthesised were screened for their antibacterial  and antifungal properties.  Among the compounds, 4d showed  antimicrobial activity against Candida albicans ATCC 60193 and Candida  tropicalis ATCC 13803.

 

Compounds 2 were synthesised via the reaction of  4-amino-5-thiophen-2-yl-methyl-2,4-dihydro-[1,2,4]-triazol-3-one (1)  with aldehydes.  Compounds 3 and 4 were obtained from compounds 2 with  bromo acetophenone and ethyl bromoacetate, respectively.  The  synthesis of compounds 2, 3, and 4 and crystal structure of compound  2a are being reported.  The molecular structures were identified by  IR, 1H-NMR, 13C-NMR, MS, and elemental analyses.  Compound 2a  crystallises in the monoclinic P 21/n space group, with a = 6.565(5)  Å, b = 18.278(5) Å, c = 13.8166(18) Å, b = 96.227(5)°, V =  1553.6(14) Å3, Z = 4.  The newly compounds synthesised were screened for their antibacterial  and antifungal properties.  Among the compounds, 4d showed  antimicrobial activity against Candida albicans ATCC 60193 and Candida  tropicalis ATCC 13803.

Makale detayları

Synthesis and characterisations of some new 2,4-dihydro-[1,2,4]-triazol-3-one derivatives and X-ray crystal structures of 4-(3-phenylallylideneamino)-5- thiophen-2-yl-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Yazarlar: Kemal SANCAK | Yasemin ÜNVER | Canan KAZAK | Esra DÜĞDÜ | Burcu ARSLAN

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2010 Vol.34 Issue 5, pp.771-780

Belge Tipi: Makale

Yayın Tarihi: 4/2010

Belge Dili: İngilizce

Document ID (Org No.): 2000727987

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

DOI: https://doi.org/10.3906/vet-1110-43

Sayı

Yazarlar:

Kemal SANCAK | Yasemin ÜNVER | Canan KAZAK | Esra DÜĞDÜ | Burcu ARSLAN

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2010 Vol.34 Issue 5, pp.771-780

Belge Tipi:

Makale

Yayın Tarihi:

4/2010

Belge Dili:

İngilizce

Document ID (Org No.):

2000727987

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/vet-1110-43