The Effects of Allograft Combined with Ozone Therapy on Regeneration of Calvarial Defects in Rats

Hülya Toker

doi:https://doi.org/10.7126/cumudj.298891

Makale detayları

The Effects of Allograft Combined with Ozone Therapy on Regeneration of Calvarial Defects in Rats

Yazarlar:

Hülya Toker

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Cumhuriyet Dental Journal 2016 Vol.19 Issue 3, pp.205-213

Belge Tipi:

Makale

Yayın Tarihi:

3/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000734996

DOI:

https://doi.org/10.7126/cumudj.298891

Özet:

 


Objective: Ozone accelerates wound healing and increases oxygen supply. The
purpose of this study was to investigate the effect of ozone therapy combined
with bone allograft on bone regeneration in rats with calvarial defects, histomorphometrically
and histopathologically.


Material-Method: Twenty four male Wistar rats were used in
this study. A 5 mm diameter critical-size defects were created in all rats
using a trephine bur. The rats were divided into 4 groups; empty defect
(control) (n=6), ozone application into the control defect (control+ ozone)
group (n=6), defect filled with allograft (Allograft) group (n=6), ozone
combined with allograft application (allograft + ozone) group (n=6). Gaseous
ozone administered at 80% density for 14 days. The animals were euthanized at
8-week.
Total bone area was measured
histomorphometrically and osteoclast and osteoblast number were analyzed
histopathologically. 


Results: The
osteoblast numbers increased in allograft + ozone group compared to the
allograft group (p<0.05). The control defects showed significantly less new
bone formation than those of the allograft groups at 8 weeks (p<0.05). Total
bone area was significantly higher in allograft+ozone group than those of the
allograft group (p<0.05).  









Conclusions: Within
the limitations of this study, we suggested that allograft+ozone combination
increased osteoblast number and new bone area. However, further studies are
needed to investigate the mechanisms of action of ozone on bone regeneration.


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Makale detayları

The Effects of Allograft Combined with Ozone Therapy on Regeneration of Calvarial Defects in Rats

Yazarlar: Hülya Toker

Ana Başlıklar: Sağlık teşvikleri

Dergi: Cumhuriyet Dental Journal 2016 Vol.19 Issue 3, pp.205-213

Belge Tipi: Makale

Yayın Tarihi: 3/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000734996

DOI: https://doi.org/10.7126/cumudj.298891

Sayı

Yazarlar:

Hülya Toker

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Cumhuriyet Dental Journal 2016 Vol.19 Issue 3, pp.205-213

Belge Tipi:

Makale

Yayın Tarihi:

3/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000734996

DOI:

https://doi.org/10.7126/cumudj.298891