Pentoxifylline attenuates mucosal damage in an experimental model of rat colitis by modulating tissue biomarkers of inflammation, oxidative stress, and fibrosis

Eylem KARATAY; Özlem Gül UTKU; Harun ERDAL; Mehmet ARHAN; İbrahim Koral ÖNAL; Mehmet İBİŞ; Özgür EKİNCİ; Canan Yilmaz DEMİRTAŞ; Giyaseddin Şükrü DUMLU

Makale detayları

Pentoxifylline attenuates mucosal damage in an experimental model of rat colitis by modulating tissue biomarkers of inflammation, oxidative stress, and fibrosis

Yazarlar:

Eylem KARATAY | Özlem Gül UTKU | Harun ERDAL | Mehmet ARHAN | İbrahim Koral ÖNAL | Mehmet İBİŞ | Özgür EKİNCİ | Canan Yilmaz DEMİRTAŞ | Giyaseddin Şükrü DUMLU

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 1, pp.348-356

Belge Tipi:

Makale

Yayın Tarihi:

1/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000751636

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: This study was designed to identify the effect of pentoxifylline on trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats.  Materials and methods: Forty-two female Wistar rats were randomly divided into 7 groups: group A, TNBS + intraperitoneal (IP) pentoxifylline; group B, TNBS + IP saline; group C, TNBS + intrarectal (IR) pentoxifylline; group D, TNBS + IR saline; group E, IP pentoxifylline + TNBS; group F, IP saline + TNBS; group G, IR saline. Pentoxifylline was given daily for 3 days before or 6 days after the induction of colitis. Rats were killed after 6 days.  Results: IP and IR pentoxifylline similarly and significantly reduced damage and histopathological scores. Pentoxifylline attenuated the accumulation of malonyldialdehyde and transforming growth factor β1 and the activities of myeloperoxidase, matrix metalloproteinase-3, and tissue inhibitor of metalloproteinases-1, and it also restored superoxide dismutase activity. The IP route was more effective than the IR route in this regard. Administration of IP pentoxifylline before or after induction did not influence all parameters.  Conclusions: Pentoxifylline showed a therapeutic effect in this experimental colitis model. IP administration seemed to be better. This effect may occur as a result of inhibition of oxidative stress and metalloproteinase activity.

Makale detayları

Pentoxifylline attenuates mucosal damage in an experimental model of rat colitis by modulating tissue biomarkers of inflammation, oxidative stress, and fibrosis

Yazarlar: Eylem KARATAY | Özlem Gül UTKU | Harun ERDAL | Mehmet ARHAN | İbrahim Koral ÖNAL | Mehmet İBİŞ | Özgür EKİNCİ | Canan Yilmaz DEMİRTAŞ | Giyaseddin Şükrü DUMLU

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2017 Vol.47 Issue 1, pp.348-356

Belge Tipi: Makale

Yayın Tarihi: 1/2017

Belge Dili: İngilizce

Document ID (Org No.): 2000751636

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Eylem KARATAY | Özlem Gül UTKU | Harun ERDAL | Mehmet ARHAN | İbrahim Koral ÖNAL | Mehmet İBİŞ | Özgür EKİNCİ | Canan Yilmaz DEMİRTAŞ | Giyaseddin Şükrü DUMLU

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 1, pp.348-356

Belge Tipi:

Makale

Yayın Tarihi:

1/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000751636

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144