Microbiological and clinical data analysis of 32 patients with Nocardia infections in Yantai

Hong-xia YU; Ming LIU; Zeng-hui PU; Yan LIU; Mao-mao ZHAO

Makale detayları

Microbiological and clinical data analysis of 32 patients with Nocardia infections in Yantai

Yazarlar:

Hong-xia YU | Ming LIU | Zeng-hui PU | Yan LIU | Mao-mao ZHAO

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 2, pp.366-371

Belge Tipi:

Makale

Yayın Tarihi:

3/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750836

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: Nocardia is an opportunistic pathogen that mostly a ects hosts with immune de ciencies. Recently, the widespread use of immunosuppressive agents and antitumor drugs has led to an increasing number of Nocardia infections being reported. However, it is di cult to con rm this diagnosis owing to the slow growth of the bacterium and its complex resultant clinical manifestations, potentially delaying treatment and increasing mortality.  us, further knowledge on the clinical characteristics of Nocardia infection is required. Hence, this study aimed to review the demographics, comorbidities, clinical presentation, microbiology, treatment, and outcomes of Nocardia infections in Yantai.  Materials and methods:  This is a retrospective study including 32 patients identified to have Nocardia infection from the Yantai Yuhuangding Hospital. The relevant patient samples were collected by two researchers, while the other researchers analyzed the relevant data.  Results: The male to female ratio among the 32 patients was 3:5, and 23 patients (71.9%) were immunocompromised. Pulmonary sites of infection were the most common (65.6% of patients). N. brasiliensis infections were present in 25.0% and N. asteroides infections were present in 21.9% of patients. Because of limited biotechnological resources, Nocardia spp. in 50.0% of cases were not classi ed.  e TMP-SMX resistance rate among isolates was 9.4%. All isolates were susceptible to amikacin, ce riaxone, and imipenem.  Conclusion: In Yantai, immunocompromised patients predominate among cases of Nocardia infection.  e rate of occurrence was higher in females than in males. Because of potential TMP-SMX resistance, treatment for Nocardia infection should be based on drug susceptibility or should include combination therapy.

Makale detayları

Microbiological and clinical data analysis of 32 patients with Nocardia infections in Yantai

Yazarlar: Hong-xia YU | Ming LIU | Zeng-hui PU | Yan LIU | Mao-mao ZHAO

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 2, pp.366-371

Belge Tipi: Makale

Yayın Tarihi: 3/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000750836

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Hong-xia YU | Ming LIU | Zeng-hui PU | Yan LIU | Mao-mao ZHAO

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 2, pp.366-371

Belge Tipi:

Makale

Yayın Tarihi:

3/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750836

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144