Effects of Angiotensin Converting Enzyme Inhibitors in Healthy Rats and in Rats With Carbon Tetrachloride-Induced Toxic Hepatitis

Ercüment OVALI

Makale detayları

Effects of Angiotensin Converting Enzyme Inhibitors in Healthy Rats and in Rats With Carbon Tetrachloride-Induced Toxic Hepatitis

Yazarlar:

Ercüment OVALI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 4, pp.321-326

Belge Tipi:

Makale

Yayın Tarihi:

3/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000757567

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Sulphydryl-containing captopril  (CPR) appears to act as a scavanger of  oxygen derived free radicals. This is not  present in other angiotensin-converting  enzymes such as enalapril (EPR). The  hepatotoxic effect of carbon tetrachloride  (CCl4) may result from induction of reactive  oxygen free radicals. The aim of this study  was to analyse the effects of CPR and non-  sulphydryl-containing enalapril (EPR) in  healthy rats and in rats with CCL4-induced  toxic hepatitis.  The rats were divided into two major groups.  The first group consisted of healthy rats, and  the second group consisted of rats with CCl4-  induced toxic hepatitis. Each major group  was sub-divided into 3 groups, where CPR,  EPR, or a placebo was administered. The  resulting 6 sub-groups were analysed for the  hepatic effects of CPR and EPR in healthy  rats and in rats with CCl4-induced toxic  hepatitis.  Co-administration of CPR or EPR with CCl4  lead to an increase in hepatic enzyme levels,  and to a greater level of liver damage in  comparison with CCl4 alone.  In conclusion, both CPR and EPR may lead to  hepatotoxicity, and sulphydryl-containing  CPR does not appear to protect the liver  from the toxic oxidant effect of CCl4.

 

Sulphydryl-containing captopril  (CPR) appears to act as a scavanger of  oxygen derived free radicals. This is not  present in other angiotensin-converting  enzymes such as enalapril (EPR). The  hepatotoxic effect of carbon tetrachloride  (CCl4) may result from induction of reactive  oxygen free radicals. The aim of this study  was to analyse the effects of CPR and non-  sulphydryl-containing enalapril (EPR) in  healthy rats and in rats with CCL4-induced  toxic hepatitis.  The rats were divided into two major groups.  The first group consisted of healthy rats, and  the second group consisted of rats with CCl4-  induced toxic hepatitis. Each major group  was sub-divided into 3 groups, where CPR,  EPR, or a placebo was administered. The  resulting 6 sub-groups were analysed for the  hepatic effects of CPR and EPR in healthy  rats and in rats with CCl4-induced toxic  hepatitis.  Co-administration of CPR or EPR with CCl4  lead to an increase in hepatic enzyme levels,  and to a greater level of liver damage in  comparison with CCl4 alone.  In conclusion, both CPR and EPR may lead to  hepatotoxicity, and sulphydryl-containing  CPR does not appear to protect the liver  from the toxic oxidant effect of CCl4.

Makale detayları

Effects of Angiotensin Converting Enzyme Inhibitors in Healthy Rats and in Rats With Carbon Tetrachloride-Induced Toxic Hepatitis

Yazarlar:

Ercüment OVALI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 4, pp.321-326

Belge Tipi:

Makale

Yayın Tarihi:

3/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000757567

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Captopril

enalapril

carbon tetrachloride

hepatotoxicity.

Sayı

Makale detayları

Effects of Angiotensin Converting Enzyme Inhibitors in Healthy Rats and in Rats With Carbon Tetrachloride-Induced Toxic Hepatitis

Yazarlar: Ercüment OVALI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2000 Vol.30 Issue 4, pp.321-326

Belge Tipi: Makale

Yayın Tarihi: 3/2000

Belge Dili: Türkçe

Document ID (Org No.): 2000757567

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Captopril

enalapril

carbon tetrachloride

hepatotoxicity.

Sayı

Yazarlar:

Ercüment OVALI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 4, pp.321-326

Belge Tipi:

Makale

Yayın Tarihi:

3/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000757567

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144