Triglyceride Glucose Index: As A Glycemic Control Indicator

Muzaffer Katar; Osman Demir

Makale detayları

Triglyceride Glucose Index: As A Glycemic Control Indicator

Yazarlar:

Muzaffer Katar | Osman Demir

Yayıncı:

Harran University

Ana Başlıklar:

Klinik Kimya

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 2, pp.357-363

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343948

pISSN:

1304-9623

Anahtar kelimeler:

Özet:

 Background: Type-2 Diabetes Mellitus T2DM continues to be the most common endocrine disease today. Easily accessible, accurate and reproducible markers are needed in addition to the accepted markers to evaluate insulin resistance IR and glycemic control. Therefore, our study aimed to evaluate the use of triglyceride glucose index TyGI as an indicator for insulin resistance and glycemic control. Materials and Methods: TriglycerideTG, HbA1c, fasting blood glucose FBG, and total insulin TI values of 953 samples, studied simultaneously in our Faculty of Medicine Hospital Laboratory between March 2023 and August 2023, were retrospectively evaluated. The patients were divided into two groups as good andor poor glycemic control regarding their HbA1c, and the Homeostatic Model Assessment of Insulin Resistance HOMA-IR values. Receiver Operating Characteristic ROC analysis was performed to assess the ability of TyGI to discriminate between good andor poor glycemic control for each of HOMA-IR and HbA1c. Statistical significance level was accepted as p0.05. Multivariate logistic regression analysis was performed as well. Results: A total of 953 patients; with the mean age of 40,8316,78 participated in the study. According to gender, all parameters except age p: 0,613 showed significant differences p0.001. There were significant differences for FBG, HbA1c, HOMA-IR, TI, TG and TyGI parameters according to cut-off values in all two study groups p0.001. TG showed high positive correlation with TyGI r: 0.796, p0.001 and moderate positive correlation with FBG r: 0.616, p0.001 for both study groups, but low positive correlation with the others. TyGI, had a high selectivity and specificity for HOMA-IR with 8,76 cut-off value AUC:0,72, Se:65, Sp:70 p0.001: 95 CI:0,69-0,75. In ROC analysis, TyGI had the highest AUC value for HbA1c, and the lowest for HOMA-IR group. The risk of poor glycemic control for HOMA-IR in men is 2.247 times higher than in women. As age increases by one unit, the risk of poor glycemic cont-rol for HOMA-IR increases by 1.045 times. Conclusions: TyGI was significantly raised in incident T2DM patients with poor glycemic control. TyGI can act as s simple and useful markers that have the strong predictive capability to identify insuline re-sistance and anticipate the development of incident T2DM.

 Background: Type-2 Diabetes Mellitus T2DM continues to be the most common endocrine disease today. Easily accessible, accurate and reproducible markers are needed in addition to the accepted markers to evaluate insulin resistance IR and glycemic control. Therefore, our study aimed to evaluate the use of triglyceride glucose index TyGI as an indicator for insulin resistance and glycemic control. Materials and Methods: TriglycerideTG, HbA1c, fasting blood glucose FBG, and total insulin TI values of 953 samples, studied simultaneously in our Faculty of Medicine Hospital Laboratory between March 2023 and August 2023, were retrospectively evaluated. The patients were divided into two groups as good andor poor glycemic control regarding their HbA1c, and the Homeostatic Model Assessment of Insulin Resistance HOMA-IR values. Receiver Operating Characteristic ROC analysis was performed to assess the ability of TyGI to discriminate between good andor poor glycemic control for each of HOMA-IR and HbA1c. Statistical significance level was accepted as p0.05. Multivariate logistic regression analysis was performed as well. Results: A total of 953 patients; with the mean age of 40,8316,78 participated in the study. According to gender, all parameters except age p: 0,613 showed significant differences p0.001. There were significant differences for FBG, HbA1c, HOMA-IR, TI, TG and TyGI parameters according to cut-off values in all two study groups p0.001. TG showed high positive correlation with TyGI r: 0.796, p0.001 and moderate positive correlation with FBG r: 0.616, p0.001 for both study groups, but low positive correlation with the others. TyGI, had a high selectivity and specificity for HOMA-IR with 8,76 cut-off value AUC:0,72, Se:65, Sp:70 p0.001: 95 CI:0,69-0,75. In ROC analysis, TyGI had the highest AUC value for HbA1c, and the lowest for HOMA-IR group. The risk of poor glycemic control for HOMA-IR in men is 2.247 times higher than in women. As age increases by one unit, the risk of poor glycemic cont-rol for HOMA-IR increases by 1.045 times. Conclusions: TyGI was significantly raised in incident T2DM patients with poor glycemic control. TyGI can act as s simple and useful markers that have the strong predictive capability to identify insuline re-sistance and anticipate the development of incident T2DM.

 Background: Type-2 Diabetes Mellitus T2DM continues to be the most common endocrine disease today. Easily accessible, accurate and reproducible markers are needed in addition to the accepted markers to evaluate insulin resistance IR and glycemic control. Therefore, our study aimed to evaluate the use of triglyceride glucose index TyGI as an indicator for insulin resistance and glycemic control. Materials and Methods: TriglycerideTG, HbA1c, fasting blood glucose FBG, and total insulin TI values of 953 samples, studied simultaneously in our Faculty of Medicine Hospital Laboratory between March 2023 and August 2023, were retrospectively evaluated. The patients were divided into two groups as good andor poor glycemic control regarding their HbA1c, and the Homeostatic Model Assessment of Insulin Resistance HOMA-IR values. Receiver Operating Characteristic ROC analysis was performed to assess the ability of TyGI to discriminate between good andor poor glycemic control for each of HOMA-IR and HbA1c. Statistical significance level was accepted as p0.05. Multivariate logistic regression analysis was performed as well. Results: A total of 953 patients; with the mean age of 40,8316,78 participated in the study. According to gender, all parameters except age p: 0,613 showed significant differences p0.001. There were significant differences for FBG, HbA1c, HOMA-IR, TI, TG and TyGI parameters according to cut-off values in all two study groups p0.001. TG showed high positive correlation with TyGI r: 0.796, p0.001 and moderate positive correlation with FBG r: 0.616, p0.001 for both study groups, but low positive correlation with the others. TyGI, had a high selectivity and specificity for HOMA-IR with 8,76 cut-off value AUC:0,72, Se:65, Sp:70 p0.001: 95 CI:0,69-0,75. In ROC analysis, TyGI had the highest AUC value for HbA1c, and the lowest for HOMA-IR group. The risk of poor glycemic control for HOMA-IR in men is 2.247 times higher than in women. As age increases by one unit, the risk of poor glycemic cont-rol for HOMA-IR increases by 1.045 times. Conclusions: TyGI was significantly raised in incident T2DM patients with poor glycemic control. TyGI can act as s simple and useful markers that have the strong predictive capability to identify insuline re-sistance and anticipate the development of incident T2DM.

 Amaç: Tip-2 Diyabetes Mellitus T2DM günümüzde en yaygın endokrin hastalık olmaya devam etmekte-dir. İnsülin direncini İD ve glisemik kontrolü değerlendirmek için kabul görmüş belirteçlere ek olarak kolay erişilebilir, doğru ve tekrarlanabilir belirteçlere ihtiyaç duyulmaktadır. Bu nedenle çalışmamızda insülin direnci ve glisemik kontrol için bir gösterge olarak trigliserid glikoz indeksinin TyGI kullanımını değerlendirmeyi amaçladık. Materyal ve Metod: Mart 2023 ile Ağustos 2023 tarihleri arasında Tıp Fakültesi Hastanesi Laboratuvarı-mızda eş zamanlı olarak incelenen 953 örneğin trigliserid TG, HbA1c, açlık kan şekeri AKŞ ve toplam insülin Tİ değerleri geriye dönük olarak incelendi. Hastalar; HbA1c ve homeostasis model değerlendir-mesiyle tahmin edilen insülin direnci HOMA-İD değerleri açısından iyi glisemik kontrol veveya kötü glisemik kontrol olmak üzere iki gruba ayrıldı. TyGInin, HOMA-İD ve HbA1cnin her biri için iyi veveya kötü glisemik kontrol arasında ayrım yapabilme yeteneğini değerlendirmek amacıyla Duyarlılık ve Özgül-lük Analizi DÖA yapıldı. İstatistiksel anlamlılık düzeyi p0,05 olarak kabul edildi. Ayrıca çok değişkenli lojistik regresyon analizi yapıldı. Bulgular: Çalışmaya yaş ortalaması 40,8316,78 olan toplam 953 hasta katıldı. Cinsiyete göre yaş p: 0,613 hariç tüm parametreler anlamlı farklılıklar gösterdi p0,005. Her iki çalışma grubunda da kesme değerlerine göre AKŞ, HbA1c, HOMA-İD, Tİ, TG ve TyGI parametreleri için anlamlı farklılıklar vardı p0,001. TG, her iki çalışma grubu için de TyGI ile yüksek pozitif korelasyon r: 0,796, p0,001 ve AKŞ ile orta derecede pozitif korelasyon r: 0,616, p0,001 gösterdi ancak diğerleri ile düşük pozitif korelas-yon gösterdi. TyGI, 8,76 kesim değeri Eğri Altı Alan EAA:0,72, Duyarlılık:65, Seçicilik:70 p0.001: 95 GA:0,69-0,75 ile HOMA-İD için yüksek seçiciliğe ve duyarlılığa sahipti. TyGI; HbA1c için en yüksek EAAya ve HOMA-İD grubu için ise en düşük EAAya sahipti. Erkeklerde HOMA-İD için kötü glisemik kontrol riski kadınlara göre 2.247 kat daha fazladır. Yaş bir birim arttıkça, HOMA-İD için kötü glisemik kontrol riski 1.045 kat artmaktadır. Sonuç: TyGI, kötü glisemik kontrole sahip yeni T2DM hastalarında önemli ölçüde yükselmiştir. TyGI, insülin direncini belirlemek ve yeni T2DM gelişimini önceden tespit etmek için güçlü öngörücü yetene-ğe sahip basit ve kullanışlı bir belirteç olarak işlev görebilir.

Makale detayları

Triglyceride Glucose Index: As A Glycemic Control Indicator

Yazarlar:

Muzaffer Katar | Osman Demir

Yayıncı:

Harran University

Ana Başlıklar:

Klinik Kimya

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 2, pp.357-363

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343948

pISSN:

1304-9623

Diabetes Mellitus

Insulin Resistance

Glycemic Control

Triglyceride

GlucoseDiabetes Mellitus

İnsülin Direnci

Glisemik Kontrol

Trigliserit

Glikoz

Sayı

Makale detayları

Yazarlar: Muzaffer Katar | Osman Demir

Yayıncı: Harran University

Ana Başlıklar: Klinik Kimya

Dergi: Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 2, pp.357-363

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001343948

pISSN: 1304-9623

Sayı

Yazarlar:

Muzaffer Katar | Osman Demir

Yayıncı:

Harran University

Ana Başlıklar:

Klinik Kimya

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 2, pp.357-363

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343948

pISSN:

1304-9623