Evaluation of Antioxidant Activity of 1, 2, 4-Triazole Derivatives With Morpholine Moiety

Roman SHCHERBYNA; Yevhen PRUHLO; Maryna DUCHENKO; Mariia KULAGİNA; Victoriia KUDRİA; Vashchuk VALENTYNA

doi:https://doi.org/10.52794/hujpharm.1033112

Makale detayları

Evaluation of Antioxidant Activity of 1, 2, 4-Triazole Derivatives With Morpholine Moiety

Yazarlar:

Roman SHCHERBYNA | Yevhen PRUHLO | Maryna DUCHENKO | Mariia KULAGİNA | Victoriia KUDRİA | Vashchuk VALENTYNA

Yayıncı:

Hacettepe University

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy 2022 Vol.42 Issue 2, pp.73-82

Belge Tipi:

Makale

Yayın Tarihi:

5/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000454263

Sıklık:

Üç Aylık

eISSN:

2458-8806

DOI:

https://doi.org/10.52794/hujpharm.1033112

Özet:

 

The aim of the work was to study the antioxidant activity of 4-R-3- (morpholinomethyl)-4H-1,2,4-triazole-5-thioles and their alkyl derivatives in vitro using the method of non-enzymatic initiation of lipid peroxidation. Among the 45 compounds studied, 8 showed varying degrees of AOA. The most pronounced AOA has 4-amino-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thiol. It was found that in most cases the introduction in alkyl-derivatives of 4-R-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thioles free amino group or phenyl substituent to the N4 atom of the 1,2,4-triazole nucleus, accompanied with increasing of AOA for test substances. In almost all cases, the presence on the N4 atom of 1,2,4-triazole nucleus methyl or ethyl groups has the opposite effect, even in comparison with control groups.

Makale detayları

Evaluation of Antioxidant Activity of 1, 2, 4-Triazole Derivatives With Morpholine Moiety

Yazarlar: Roman SHCHERBYNA | Yevhen PRUHLO | Maryna DUCHENKO | Mariia KULAGİNA | Victoriia KUDRİA | Vashchuk VALENTYNA

Yayıncı: Hacettepe University

Ana Başlıklar: Farmakoloji ve terapötik

Dergi: Hacettepe University Journal of the Faculty of Pharmacy 2022 Vol.42 Issue 2, pp.73-82

Belge Tipi: Makale

Yayın Tarihi: 5/2022

Belge Dili: İngilizce

Document ID (Org No.): 2000454263

Sıklık: Üç Aylık

eISSN: 2458-8806

DOI: https://doi.org/10.52794/hujpharm.1033112

Sayı

Yazarlar:

Roman SHCHERBYNA | Yevhen PRUHLO | Maryna DUCHENKO | Mariia KULAGİNA | Victoriia KUDRİA | Vashchuk VALENTYNA

Yayıncı:

Hacettepe University

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy 2022 Vol.42 Issue 2, pp.73-82

Belge Tipi:

Makale

Yayın Tarihi:

5/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000454263

Sıklık:

Üç Aylık

eISSN:

2458-8806

DOI:

https://doi.org/10.52794/hujpharm.1033112