Protective Evidence of Clarithromycin after Ischemic Cerebral Injury; an Experimental Study

Ali Rıza Güvercin; Mehmet Aktoklu; Erhan Arslan; Ayhan Kanat; Uğur Yazar; Mehmet Orbay Bıyık; Ahmet Alver

Makale detayları

Protective Evidence of Clarithromycin after Ischemic Cerebral Injury; an Experimental Study

Yazarlar:

Ali Rıza Güvercin | Mehmet Aktoklu | Erhan Arslan | Ayhan Kanat | Uğur Yazar | Mehmet Orbay Bıyık | Ahmet Alver

Yayıncı:

Ordu University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Middle Black Sea Journal of Health Science Vol.11 Issue 1, pp.44-56

Belge Tipi:

Makale

Yayın Tarihi:

2/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341827

pISSN:

2149-7796

Anahtar kelimeler:

Özet:

 Objective: Acute ischemic stroke is caused by a reduction in cerebral blood flow, leading to brain ischemic and subsequent cell death. The therapeutic options available for this condition are limited. The inflammatory response associated with the ischemic injury may influence the outcomes of ischemic stroke. Clarithromycin is a widely used antibiotic in medical practice. This study aimed to investigate the effect of clarithromycin on brain ischemic injury. Methods: In this study, 38 Sprague Dawley female rats were used and divided into four main groups: the pure control group, the ischemia group, the shamcontrol group, and the ischemicclaritromycin group. A temporary clip was placed in the bilateral carotid arteries of rats for 45 minutes. One group administered a dose of clarithromycin, and the tissue and blood samples of all four groups underwent biochemical evaluation. The results were subjected to statistical analysis. Results: The administration of clarithromycin to animals resulted in a reduction in malondialdehyde levels in brain tissues within the study group. Furthermore, Bedersons motor scores were observed to be higher in the clarithromycin-treated group in comparison to the ischemia group p0.092. Conclusion: A potential correlation exists between post-stroke infections and prognosis, suggesting that prophylactic antibiotic treatment may be beneficial. This study indicates that clarithromycin exerts a neuroprotective effect on cerebral ischemic injury following a stroke.

 Objective: Acute ischemic stroke is caused by a reduction in cerebral blood flow, leading to brain ischemic and subsequent cell death. The therapeutic options available for this condition are limited. The inflammatory response associated with the ischemic injury may influence the outcomes of ischemic stroke. Clarithromycin is a widely used antibiotic in medical practice. This study aimed to investigate the effect of clarithromycin on brain ischemic injury. Methods: In this study, 38 Sprague Dawley female rats were used and divided into four main groups: the pure control group, the ischemia group, the shamcontrol group, and the ischemicclaritromycin group. A temporary clip was placed in the bilateral carotid arteries of rats for 45 minutes. One group administered a dose of clarithromycin, and the tissue and blood samples of all four groups underwent biochemical evaluation. The results were subjected to statistical analysis. Results: The administration of clarithromycin to animals resulted in a reduction in malondialdehyde levels in brain tissues within the study group. Furthermore, Bedersons motor scores were observed to be higher in the clarithromycin-treated group in comparison to the ischemia group p0.092. Conclusion: A potential correlation exists between post-stroke infections and prognosis, suggesting that prophylactic antibiotic treatment may be beneficial. This study indicates that clarithromycin exerts a neuroprotective effect on cerebral ischemic injury following a stroke.

 Objective: Acute ischemic stroke is caused by a reduction in cerebral blood flow, leading to brain ischemic and subsequent cell death. The therapeutic options available for this condition are limited. The inflammatory response associated with the ischemic injury may influence the outcomes of ischemic stroke. Clarithromycin is a widely used antibiotic in medical practice. This study aimed to investigate the effect of clarithromycin on brain ischemic injury. Methods: In this study, 38 Sprague Dawley female rats were used and divided into four main groups: the pure control group, the ischemia group, the shamcontrol group, and the ischemicclaritromycin group. A temporary clip was placed in the bilateral carotid arteries of rats for 45 minutes. One group administered a dose of clarithromycin, and the tissue and blood samples of all four groups underwent biochemical evaluation. The results were subjected to statistical analysis. Results: The administration of clarithromycin to animals resulted in a reduction in malondialdehyde levels in brain tissues within the study group. Furthermore, Bedersons motor scores were observed to be higher in the clarithromycin-treated group in comparison to the ischemia group p0.092. Conclusion: A potential correlation exists between post-stroke infections and prognosis, suggesting that prophylactic antibiotic treatment may be beneficial. This study indicates that clarithromycin exerts a neuroprotective effect on cerebral ischemic injury following a stroke.

 Objective: Acute ischemic stroke is caused by a reduction in cerebral blood flow, leading to brain ischemic and subsequent cell death. The therapeutic options available for this condition are limited. The inflammatory response associated with the ischemic injury may influence the outcomes of ischemic stroke. Clarithromycin is a widely used antibiotic in medical practice. This study aimed to investigate the effect of clarithromycin on brain ischemic injury. Methods: In this study, 38 Sprague Dawley female rats were used and divided into four main groups: the pure control group, the ischemia group, the shamcontrol group, and the ischemicclaritromycin group. A temporary clip was placed in the bilateral carotid arteries of rats for 45 minutes. One group administered a dose of clarithromycin, and the tissue and blood samples of all four groups underwent biochemical evaluation. The results were subjected to statistical analysis. Results: The administration of clarithromycin to animals resulted in a reduction in malondialdehyde levels in brain tissues within the study group. Furthermore, Bedersons motor scores were observed to be higher in the clarithromycin-treated group in comparison to the ischemia group p0.092. Conclusion: A potential correlation exists between post-stroke infections and prognosis, suggesting that prophylactic antibiotic treatment may be beneficial. This study indicates that clarithromycin exerts a neuroprotective effect on cerebral ischemic injury following a stroke.

Makale detayları

Protective Evidence of Clarithromycin after Ischemic Cerebral Injury; an Experimental Study

Yazarlar:

Ali Rıza Güvercin | Mehmet Aktoklu | Erhan Arslan | Ayhan Kanat | Uğur Yazar | Mehmet Orbay Bıyık | Ahmet Alver

Yayıncı:

Ordu University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Middle Black Sea Journal of Health Science Vol.11 Issue 1, pp.44-56

Belge Tipi:

Makale

Yayın Tarihi:

2/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341827

pISSN:

2149-7796

cerebral injury

clarithromycin

ischemia

neuroprotection

Sayı

Makale detayları

Protective Evidence of Clarithromycin after Ischemic Cerebral Injury; an Experimental Study

Yazarlar: Ali Rıza Güvercin | Mehmet Aktoklu | Erhan Arslan | Ayhan Kanat | Uğur Yazar | Mehmet Orbay Bıyık | Ahmet Alver

Yayıncı: Ordu University

Ana Başlıklar: Clinical Sciences (Other)

Dergi: Middle Black Sea Journal of Health Science Vol.11 Issue 1, pp.44-56

Belge Tipi: Makale

Yayın Tarihi: 2/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001341827

pISSN: 2149-7796

cerebral injury

clarithromycin

ischemia

neuroprotection

Sayı

Yazarlar:

Ali Rıza Güvercin | Mehmet Aktoklu | Erhan Arslan | Ayhan Kanat | Uğur Yazar | Mehmet Orbay Bıyık | Ahmet Alver

Yayıncı:

Ordu University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Middle Black Sea Journal of Health Science Vol.11 Issue 1, pp.44-56

Belge Tipi:

Makale

Yayın Tarihi:

2/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341827

pISSN:

2149-7796