Therapeutic effect of Anethum graveolens L. (Dill) seed extract for the treatment of dextran sodium sulfate (DSS) induced ulcerative colitis in Wistar rats

N.A.

Makale detayları

Therapeutic effect of Anethum graveolens L. (Dill) seed extract for the treatment of dextran sodium sulfate (DSS) induced ulcerative colitis in Wistar rats

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 3, pp.770-780

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346645

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The purpose of this study was to determine whether the Anethum graveolens L. seed AGS extract has any anti-oxidant, anti-inflammatory, or immune-modulatory activities against Ulcerative colitis UC. AGS extract has found widespread use in folk medicine. Twenty seven n27 adult female Wistar albino rats were employed for the experiment involving Dextran Sodium Sulfate DSS induced UC. These rats were distributed randomly into five groups, each consisting of six animals n6, with the exception of group 1, which had three animals n3. Group 1 received 0.5 Carboxy methyl cellulose CMC p.o., Group 2 received 5 DSS p.o., Group 3 received 350 mgkg b.w. mesalazine p.o., and Groups 4, 5, respectively, received 200 and 400 mgkg AGS extract p.o. Along with administering DSS, the treatment lasted for 12 days. In comparison to the DSS-treated group, groups 4, and 5, there was a considerable weight gain. Comparing groups 4 and 5 to group 2, the groups 4 and 5 showed a substantial decrease in Disease Activity Index DAI, colon damage p0.05, spleen weight p0.05, serum IL-6 p0.0001, TNF-α p0.01, and IL-17 p0.01 levels. Rats in groups 4 and 5 had significantly higher blood IL-10 levels p0.05 and longer colons than rats in group 2 p0.05. The good results, which showed an improvement in the state of the colon epithelium after AGS extract in treatment groups, were validated by a histopathological study. In summary, AGS extract may be able to control inflammatory reactions and safeguard the colon epithelium in UC. These results support the possible therapeutic application of AGS extract.

 The purpose of this study was to determine whether the Anethum graveolens L. seed AGS extract has any anti-oxidant, anti-inflammatory, or immune-modulatory activities against Ulcerative colitis UC. AGS extract has found widespread use in folk medicine. Twenty seven n27 adult female Wistar albino rats were employed for the experiment involving Dextran Sodium Sulfate DSS induced UC. These rats were distributed randomly into five groups, each consisting of six animals n6, with the exception of group 1, which had three animals n3. Group 1 received 0.5 Carboxy methyl cellulose CMC p.o., Group 2 received 5 DSS p.o., Group 3 received 350 mgkg b.w. mesalazine p.o., and Groups 4, 5, respectively, received 200 and 400 mgkg AGS extract p.o. Along with administering DSS, the treatment lasted for 12 days. In comparison to the DSS-treated group, groups 4, and 5, there was a considerable weight gain. Comparing groups 4 and 5 to group 2, the groups 4 and 5 showed a substantial decrease in Disease Activity Index DAI, colon damage p0.05, spleen weight p0.05, serum IL-6 p0.0001, TNF-α p0.01, and IL-17 p0.01 levels. Rats in groups 4 and 5 had significantly higher blood IL-10 levels p0.05 and longer colons than rats in group 2 p0.05. The good results, which showed an improvement in the state of the colon epithelium after AGS extract in treatment groups, were validated by a histopathological study. In summary, AGS extract may be able to control inflammatory reactions and safeguard the colon epithelium in UC. These results support the possible therapeutic application of AGS extract.

 The purpose of this study was to determine whether the Anethum graveolens L. seed AGS extract has any anti-oxidant, anti-inflammatory, or immune-modulatory activities against Ulcerative colitis UC. AGS extract has found widespread use in folk medicine. Twenty seven n27 adult female Wistar albino rats were employed for the experiment involving Dextran Sodium Sulfate DSS induced UC. These rats were distributed randomly into five groups, each consisting of six animals n6, with the exception of group 1, which had three animals n3. Group 1 received 0.5 Carboxy methyl cellulose CMC p.o., Group 2 received 5 DSS p.o., Group 3 received 350 mgkg b.w. mesalazine p.o., and Groups 4, 5, respectively, received 200 and 400 mgkg AGS extract p.o. Along with administering DSS, the treatment lasted for 12 days. In comparison to the DSS-treated group, groups 4, and 5, there was a considerable weight gain. Comparing groups 4 and 5 to group 2, the groups 4 and 5 showed a substantial decrease in Disease Activity Index DAI, colon damage p0.05, spleen weight p0.05, serum IL-6 p0.0001, TNF-α p0.01, and IL-17 p0.01 levels. Rats in groups 4 and 5 had significantly higher blood IL-10 levels p0.05 and longer colons than rats in group 2 p0.05. The good results, which showed an improvement in the state of the colon epithelium after AGS extract in treatment groups, were validated by a histopathological study. In summary, AGS extract may be able to control inflammatory reactions and safeguard the colon epithelium in UC. These results support the possible therapeutic application of AGS extract.

 The purpose of this study was to determine whether the Anethum graveolens L. seed AGS extract has any anti-oxidant, anti-inflammatory, or immune-modulatory activities against Ulcerative colitis UC. AGS extract has found widespread use in folk medicine. Twenty seven n27 adult female Wistar albino rats were employed for the experiment involving Dextran Sodium Sulfate DSS induced UC. These rats were distributed randomly into five groups, each consisting of six animals n6, with the exception of group 1, which had three animals n3. Group 1 received 0.5 Carboxy methyl cellulose CMC p.o., Group 2 received 5 DSS p.o., Group 3 received 350 mgkg b.w. mesalazine p.o., and Groups 4, 5, respectively, received 200 and 400 mgkg AGS extract p.o. Along with administering DSS, the treatment lasted for 12 days. In comparison to the DSS-treated group, groups 4, and 5, there was a considerable weight gain. Comparing groups 4 and 5 to group 2, the groups 4 and 5 showed a substantial decrease in Disease Activity Index DAI, colon damage p0.05, spleen weight p0.05, serum IL-6 p0.0001, TNF-α p0.01, and IL-17 p0.01 levels. Rats in groups 4 and 5 had significantly higher blood IL-10 levels p0.05 and longer colons than rats in group 2 p0.05. The good results, which showed an improvement in the state of the colon epithelium after AGS extract in treatment groups, were validated by a histopathological study. In summary, AGS extract may be able to control inflammatory reactions and safeguard the colon epithelium in UC. These results support the possible therapeutic application of AGS extract.

Makale detayları

Therapeutic effect of Anethum graveolens L. (Dill) seed extract for the treatment of dextran sodium sulfate (DSS) induced ulcerative colitis in Wistar rats

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 3, pp.770-780

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346645

pISSN:

2630-6344

Anethum graveolens L.

ulcerative colitis

dextran sodium sulfate

antioxidant

anti-inflammatory

Sayı

Makale detayları

Therapeutic effect of Anethum graveolens L. (Dill) seed extract for the treatment of dextran sodium sulfate (DSS) induced ulcerative colitis in Wistar rats

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Basic Pharmacology

Dergi: Journal of Research in Pharmacy Vol.28 Issue 3, pp.770-780

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346645

pISSN: 2630-6344

Anethum graveolens L.

ulcerative colitis

dextran sodium sulfate

antioxidant

anti-inflammatory

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 3, pp.770-780

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346645

pISSN:

2630-6344