Synthesis, characterization, and investigation of antibacterial and antifungal properties of salt and metal complexes of 2-amino-5-chloropyridine and 2,6-pyridinedicarboxylic acid

Ayşe Polat; Halil İlkimen; Beyza Yılmaz; Elif Yurt; Aysel Gülbandılar

Makale detayları

Synthesis, characterization, and investigation of antibacterial and antifungal properties of salt and metal complexes of 2-amino-5-chloropyridine and 2,6-pyridinedicarboxylic acid

Yazarlar:

Ayşe Polat | Halil İlkimen | Beyza Yılmaz | Elif Yurt | Aysel Gülbandılar

Yayıncı:

Kütahya Dumlupinar University

Ana Başlıklar:

Transition Metal Chemistry

Dergi:

Journal of Scientific Reports-A Issue 057, pp.110-120

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314813

pISSN:

2687-6167

Anahtar kelimeler:

Özet:

 In this study, the salt 3 of 2-amino-5-chloropyridine 1 and 2,6-pyridinedicarboxylic acid 2 and the complexes of the salt H1xM22.nH2O, M  Fe III, x  1, n  3 4; M  CoII, x  2, n  4 5; M  NiII, x  2, n  5 6; M  CuII, x  2, n  4 7 were synthesized. The structures of 3-7 were suggested by NMR, AAS, IR, UV, magnetic susceptibility and molar conductivity methods. As a result of spectroscopic analysis, it was observed that all metal complexes had an ionic and octahedral structure. All substances were susceptible to Candida albicans yeast, Escherichia coli, Bacillus subtilis, Enterococcus faecalis, Pseudomonas aeruginosa, Listeria monocytogenes and Staphylococcus aureus bacteria were examined. Antimicrobial activity results were compared with Fluconazole, Ketoconazole, Chloramphenicol, Levofloxacin, Vancomycin and Cefepime. In the activity results, the best values were observed 3, 5 and 7 in S. aureus bacteria, 1 and 5 in E. coli bacteria, 1, 3 and 7 in P. aeruginoa bacteria, all compounds in L. monocytogenes bacteria, all compounds except 4 in E. faecalis bacteria, 1 and 3-5 in B. subtilis bacteria and 3, 4 and 7 in C. albicans yeast.

 In this study, the salt 3 of 2-amino-5-chloropyridine 1 and 2,6-pyridinedicarboxylic acid 2 and the complexes of the salt H1xM22.nH2O, M  Fe III, x  1, n  3 4; M  CoII, x  2, n  4 5; M  NiII, x  2, n  5 6; M  CuII, x  2, n  4 7 were synthesized. The structures of 3-7 were suggested by NMR, AAS, IR, UV, magnetic susceptibility and molar conductivity methods. As a result of spectroscopic analysis, it was observed that all metal complexes had an ionic and octahedral structure. All substances were susceptible to Candida albicans yeast, Escherichia coli, Bacillus subtilis, Enterococcus faecalis, Pseudomonas aeruginosa, Listeria monocytogenes and Staphylococcus aureus bacteria were examined. Antimicrobial activity results were compared with Fluconazole, Ketoconazole, Chloramphenicol, Levofloxacin, Vancomycin and Cefepime. In the activity results, the best values were observed 3, 5 and 7 in S. aureus bacteria, 1 and 5 in E. coli bacteria, 1, 3 and 7 in P. aeruginoa bacteria, all compounds in L. monocytogenes bacteria, all compounds except 4 in E. faecalis bacteria, 1 and 3-5 in B. subtilis bacteria and 3, 4 and 7 in C. albicans yeast.

 In this study, the salt 3 of 2-amino-5-chloropyridine 1 and 2,6-pyridinedicarboxylic acid 2 and the complexes of the salt H1xM22.nH2O, M  Fe III, x  1, n  3 4; M  CoII, x  2, n  4 5; M  NiII, x  2, n  5 6; M  CuII, x  2, n  4 7 were synthesized. The structures of 3-7 were suggested by NMR, AAS, IR, UV, magnetic susceptibility and molar conductivity methods. As a result of spectroscopic analysis, it was observed that all metal complexes had an ionic and octahedral structure. All substances were susceptible to Candida albicans yeast, Escherichia coli, Bacillus subtilis, Enterococcus faecalis, Pseudomonas aeruginosa, Listeria monocytogenes and Staphylococcus aureus bacteria were examined. Antimicrobial activity results were compared with Fluconazole, Ketoconazole, Chloramphenicol, Levofloxacin, Vancomycin and Cefepime. In the activity results, the best values were observed 3, 5 and 7 in S. aureus bacteria, 1 and 5 in E. coli bacteria, 1, 3 and 7 in P. aeruginoa bacteria, all compounds in L. monocytogenes bacteria, all compounds except 4 in E. faecalis bacteria, 1 and 3-5 in B. subtilis bacteria and 3, 4 and 7 in C. albicans yeast.

 In this study, the salt 3 of 2-amino-5-chloropyridine 1 and 2,6-pyridinedicarboxylic acid 2 and the complexes of the salt H1xM22.nH2O, M  Fe III, x  1, n  3 4; M  CoII, x  2, n  4 5; M  NiII, x  2, n  5 6; M  CuII, x  2, n  4 7 were synthesized. The structures of 3-7 were suggested by NMR, AAS, IR, UV, magnetic susceptibility and molar conductivity methods. As a result of spectroscopic analysis, it was observed that all metal complexes had an ionic and octahedral structure. All substances were susceptible to Candida albicans yeast, Escherichia coli, Bacillus subtilis, Enterococcus faecalis, Pseudomonas aeruginosa, Listeria monocytogenes and Staphylococcus aureus bacteria were examined. Antimicrobial activity results were compared with Fluconazole, Ketoconazole, Chloramphenicol, Levofloxacin, Vancomycin and Cefepime. In the activity results, the best values were observed 3, 5 and 7 in S. aureus bacteria, 1 and 5 in E. coli bacteria, 1, 3 and 7 in P. aeruginoa bacteria, all compounds in L. monocytogenes bacteria, all compounds except 4 in E. faecalis bacteria, 1 and 3-5 in B. subtilis bacteria and 3, 4 and 7 in C. albicans yeast.

Makale detayları

Synthesis, characterization, and investigation of antibacterial and antifungal properties of salt and metal complexes of 2-amino-5-chloropyridine and 2,6-pyridinedicarboxylic acid

Yazarlar:

Ayşe Polat | Halil İlkimen | Beyza Yılmaz | Elif Yurt | Aysel Gülbandılar

Yayıncı:

Kütahya Dumlupinar University

Ana Başlıklar:

Transition Metal Chemistry

Dergi:

Journal of Scientific Reports-A Issue 057, pp.110-120

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314813

pISSN:

2687-6167

2-Amino-5-chloropyridine

2,6-pyridinedicarboxylic acid

salt

metal complex

antimicrobial activity.

Sayı

Makale detayları

Synthesis, characterization, and investigation of antibacterial and antifungal properties of salt and metal complexes of 2-amino-5-chloropyridine and 2,6-pyridinedicarboxylic acid

Yazarlar: Ayşe Polat | Halil İlkimen | Beyza Yılmaz | Elif Yurt | Aysel Gülbandılar

Yayıncı: Kütahya Dumlupinar University

Ana Başlıklar: Transition Metal Chemistry

Dergi: Journal of Scientific Reports-A Issue 057, pp.110-120

Belge Tipi: Makale

Yayın Tarihi: 6/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001314813

pISSN: 2687-6167

2-Amino-5-chloropyridine

2,6-pyridinedicarboxylic acid

salt

metal complex

antimicrobial activity.

Sayı

Yazarlar:

Ayşe Polat | Halil İlkimen | Beyza Yılmaz | Elif Yurt | Aysel Gülbandılar

Yayıncı:

Kütahya Dumlupinar University

Ana Başlıklar:

Transition Metal Chemistry

Dergi:

Journal of Scientific Reports-A Issue 057, pp.110-120

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314813

pISSN:

2687-6167