Comparison of Two Anesthesia Induction Methods in Awake Extubated Children at Risk for Respiratory Adverse Events: A Retrospective Study

Funda Arun

Makale detayları

Comparison of Two Anesthesia Induction Methods in Awake Extubated Children at Risk for Respiratory Adverse Events: A Retrospective Study

Yazarlar:

Funda Arun

Yayıncı:

Selcuk University

Ana Başlıklar:

Anaesthesiology

Dergi:

Selcuk Dental Journal Vol.12 Issue 2, pp.225-229

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001356672

pISSN:

2148-7529

Anahtar kelimeler:

Özet:

 Background: The extubation phase in pediatric general anesthesia GA, particularly in children at risk for perioperative respiratory adverse events PRAEs, poses significant challenges. This study aimed to compare the effects of sevoflurane and propofol induction on respiratory complications during emergence in pediatric dental patients at risk for PRAEs. Methods: In this retrospective cohort study, 221 children aged 215 who underwent elective dental rehabilitation under GA were analyzed. Patients were assigned to induction with either sevoflurane n130 or propofol n91. All patients were extubated while awake. The primary outcome was the incidence of respiratory complications, including laryngospasm, bronchospasm, desaturation SpO₂ 95, airway obstruction, and severe coughing, during emergence and recovery. Risk factors for PRAEs were assessed using a modified ISAAC questionnaire. Results: Respiratory complications were significantly more frequent in the sevoflurane group 32 compared to the propofol group 11. Serious adverse events were observed only in the sevoflurane group 6. Although oxygen desaturation occurred more often in the sevoflurane group 21 vs. 8 cases, the difference was not statistically significant p0.1557. Demographic characteristics and distribution of most risk factors were similar between groups, though eczema-related factors were more common in the sevoflurane group. Conclusion: Propofol induction was associated with a lower incidence of respiratory complications during awake extubation in pediatric dental patients at risk for PRAEs. This study is the first to support propofol as the preferred induction agent for this high-risk population, enhancing post-awake extubation respiratory safety. Keywords: Respiratory adverse effects; general anesthesia; children; sevoflurane.

 Background: The extubation phase in pediatric general anesthesia GA, particularly in children at risk for perioperative respiratory adverse events PRAEs, poses significant challenges. This study aimed to compare the effects of sevoflurane and propofol induction on respiratory complications during emergence in pediatric dental patients at risk for PRAEs. Methods: In this retrospective cohort study, 221 children aged 215 who underwent elective dental rehabilitation under GA were analyzed. Patients were assigned to induction with either sevoflurane n130 or propofol n91. All patients were extubated while awake. The primary outcome was the incidence of respiratory complications, including laryngospasm, bronchospasm, desaturation SpO₂ 95, airway obstruction, and severe coughing, during emergence and recovery. Risk factors for PRAEs were assessed using a modified ISAAC questionnaire. Results: Respiratory complications were significantly more frequent in the sevoflurane group 32 compared to the propofol group 11. Serious adverse events were observed only in the sevoflurane group 6. Although oxygen desaturation occurred more often in the sevoflurane group 21 vs. 8 cases, the difference was not statistically significant p0.1557. Demographic characteristics and distribution of most risk factors were similar between groups, though eczema-related factors were more common in the sevoflurane group. Conclusion: Propofol induction was associated with a lower incidence of respiratory complications during awake extubation in pediatric dental patients at risk for PRAEs. This study is the first to support propofol as the preferred induction agent for this high-risk population, enhancing post-awake extubation respiratory safety. Keywords: Respiratory adverse effects; general anesthesia; children; sevoflurane.

 Background: The extubation phase in pediatric general anesthesia GA, particularly in children at risk for perioperative respiratory adverse events PRAEs, poses significant challenges. This study aimed to compare the effects of sevoflurane and propofol induction on respiratory complications during emergence in pediatric dental patients at risk for PRAEs. Methods: In this retrospective cohort study, 221 children aged 215 who underwent elective dental rehabilitation under GA were analyzed. Patients were assigned to induction with either sevoflurane n130 or propofol n91. All patients were extubated while awake. The primary outcome was the incidence of respiratory complications, including laryngospasm, bronchospasm, desaturation SpO₂ 95, airway obstruction, and severe coughing, during emergence and recovery. Risk factors for PRAEs were assessed using a modified ISAAC questionnaire. Results: Respiratory complications were significantly more frequent in the sevoflurane group 32 compared to the propofol group 11. Serious adverse events were observed only in the sevoflurane group 6. Although oxygen desaturation occurred more often in the sevoflurane group 21 vs. 8 cases, the difference was not statistically significant p0.1557. Demographic characteristics and distribution of most risk factors were similar between groups, though eczema-related factors were more common in the sevoflurane group. Conclusion: Propofol induction was associated with a lower incidence of respiratory complications during awake extubation in pediatric dental patients at risk for PRAEs. This study is the first to support propofol as the preferred induction agent for this high-risk population, enhancing post-awake extubation respiratory safety. Keywords: Respiratory adverse effects; general anesthesia; children; sevoflurane.

 Background: The extubation phase in pediatric general anesthesia GA, particularly in children at risk for perioperative respiratory adverse events PRAEs, poses significant challenges. This study aimed to compare the effects of sevoflurane and propofol induction on respiratory complications during emergence in pediatric dental patients at risk for PRAEs. Methods: In this retrospective cohort study, 221 children aged 215 who underwent elective dental rehabilitation under GA were analyzed. Patients were assigned to induction with either sevoflurane n130 or propofol n91. All patients were extubated while awake. The primary outcome was the incidence of respiratory complications, including laryngospasm, bronchospasm, desaturation SpO₂ 95, airway obstruction, and severe coughing, during emergence and recovery. Risk factors for PRAEs were assessed using a modified ISAAC questionnaire. Results: Respiratory complications were significantly more frequent in the sevoflurane group 32 compared to the propofol group 11. Serious adverse events were observed only in the sevoflurane group 6. Although oxygen desaturation occurred more often in the sevoflurane group 21 vs. 8 cases, the difference was not statistically significant p0.1557. Demographic characteristics and distribution of most risk factors were similar between groups, though eczema-related factors were more common in the sevoflurane group. Conclusion: Propofol induction was associated with a lower incidence of respiratory complications during awake extubation in pediatric dental patients at risk for PRAEs. This study is the first to support propofol as the preferred induction agent for this high-risk population, enhancing post-awake extubation respiratory safety. Keywords: Respiratory adverse effects; general anesthesia; children; sevoflurane.

Makale detayları

Comparison of Two Anesthesia Induction Methods in Awake Extubated Children at Risk for Respiratory Adverse Events: A Retrospective Study

Yazarlar:

Funda Arun

Yayıncı:

Selcuk University

Ana Başlıklar:

Anaesthesiology

Dergi:

Selcuk Dental Journal Vol.12 Issue 2, pp.225-229

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001356672

pISSN:

2148-7529

respiartory adverse effects

general anesthesia

children

sevoflurane

Sayı

Makale detayları

Comparison of Two Anesthesia Induction Methods in Awake Extubated Children at Risk for Respiratory Adverse Events: A Retrospective Study

Yazarlar: Funda Arun

Yayıncı: Selcuk University

Ana Başlıklar: Anaesthesiology

Dergi: Selcuk Dental Journal Vol.12 Issue 2, pp.225-229

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001356672

pISSN: 2148-7529

respiartory adverse effects

general anesthesia

children

sevoflurane

Sayı

Yazarlar:

Funda Arun

Yayıncı:

Selcuk University

Ana Başlıklar:

Anaesthesiology

Dergi:

Selcuk Dental Journal Vol.12 Issue 2, pp.225-229

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001356672

pISSN:

2148-7529