Copeptin: May it be a novel biomarker for insulin theraphy in diabetes? An animal study

Ece Harman HARMAN; Yavuz Dodurga; Gulsah Gundogdu; Ceylan AYADA; Gulten Erken; Vural Kucukatay; Cigir Biray AVCİ; Osman Genc

Makale detayları

Copeptin: May it be a novel biomarker for insulin theraphy in diabetes? An animal study

Yazarlar:

Ece Harman HARMAN | Yavuz Dodurga | Gulsah Gundogdu | Ceylan AYADA | Gulten Erken | Vural Kucukatay | Cigir Biray AVCİ | Osman Genc

Yayıncı:

Inonu University

Dergi:

Medicine Science 2013 Vol.2 Issue 3, pp.701-708

Belge Tipi:

Makale

Yayın Tarihi:

8/2013

Belge Dili:

Türkçe

Document ID (Org No.):

2000828666

Sıklık:

Üç Aylık

eISSN:

2147-0634

pISSN:

2147-0634

Anahtar kelimeler:

Özet:

 

Copeptin is a marker about prognosis of acute illnesses, generally. It may be also an indicator associated with treatment of chronic diseases. We aimed to evaluate copeptin levels in rat models with stress, diabetes, diabetes+insulin. Healthy male Wistar rats, about 3 months old, weighing 200 "250 g, were obtained from University Animal House. They were housed in small cages at standard conditions (24 ± 2°C and 50 ± 5% humidity) with a 12 h light/dark cycle and were fed ad libitum with standard rat chow and tap water. Rats were divided into 4 groups: 8 control (C), 8 diabetic (D), 8 diabetic+insulin (DI) and 8 stress (S) rats. Quantitative measurement of Copeptin was performed using the ELISA method (Uscn Life Sciences, USA), according to the manufactur ers instructions. Copeptin level was statistically significant decreased in D+I groups. There was no difference in copeptin level between the S, D, and C groups. Copeptin may be considered as a new tool for the comparison of the efficiencies of new therapeutic modalities in diabetes.

 

Copeptin is a marker about prognosis of acute illnesses, generally. It may be also an indicator associated with treatment of chronic diseases. We aimed to evaluate copeptin levels in rat models with stress, diabetes, diabetes+insulin. Healthy male Wistar rats, about 3 months old, weighing 200 "250 g, were obtained from University Animal House. They were housed in small cages at standard conditions (24 ± 2°C and 50 ± 5% humidity) with a 12 h light/dark cycle and were fed ad libitum with standard rat chow and tap water. Rats were divided into 4 groups: 8 control (C), 8 diabetic (D), 8 diabetic+insulin (DI) and 8 stress (S) rats. Quantitative measurement of Copeptin was performed using the ELISA method (Uscn Life Sciences, USA), according to the manufactur ers instructions. Copeptin level was statistically significant decreased in D+I groups. There was no difference in copeptin level between the S, D, and C groups. Copeptin may be considered as a new tool for the comparison of the efficiencies of new therapeutic modalities in diabetes.

Makale detayları

Copeptin: May it be a novel biomarker for insulin theraphy in diabetes? An animal study

Yazarlar: Ece Harman HARMAN | Yavuz Dodurga | Gulsah Gundogdu | Ceylan AYADA | Gulten Erken | Vural Kucukatay | Cigir Biray AVCİ | Osman Genc

Yayıncı: Inonu University

Dergi: Medicine Science 2013 Vol.2 Issue 3, pp.701-708

Belge Tipi: Makale

Yayın Tarihi: 8/2013

Belge Dili: Türkçe

Document ID (Org No.): 2000828666

Sıklık: Üç Aylık

eISSN: 2147-0634

pISSN: 2147-0634

Copeptin

insulin

diabetes

Sayı

Yazarlar:

Ece Harman HARMAN | Yavuz Dodurga | Gulsah Gundogdu | Ceylan AYADA | Gulten Erken | Vural Kucukatay | Cigir Biray AVCİ | Osman Genc

Yayıncı:

Inonu University

Dergi:

Medicine Science 2013 Vol.2 Issue 3, pp.701-708

Belge Tipi:

Makale

Yayın Tarihi:

8/2013

Belge Dili:

Türkçe

Document ID (Org No.):

2000828666

Sıklık:

Üç Aylık

eISSN:

2147-0634

pISSN:

2147-0634