Interleukin-23 receptor gene polymorphisms in osteoporosis

Firdevs Ulutaş; Ozan Çetin; Veli Çobankara

Makale detayları

Interleukin-23 receptor gene polymorphisms in osteoporosis

Yazarlar:

Firdevs Ulutaş | Ozan Çetin | Veli Çobankara

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Rheumatology and Arthritis

Dergi:

The European Research Journal Vol.9 Issue 6, pp.1277-1285

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001294088

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objectives: Osteoporosis OP is a usual disease with a possible genetic predisposition. IL-23 plays a role in physiological bone remodeling and regulates the activity of cells of the bone either directly or indirectly on bone-resorbing osteoclasts as well as on bone-forming osteoblasts. Recent animal and human trials have revealed the main pro-osteoclastogenic activities for the IL-23 pathway. We examined nine single nucleotide polymorphisms SNPs in the interleukin-23 receptor IL-23R in 100 OP patients and gender- and age-matched 96 healthy volunteers. The most analyzed SNPs in the recent rheumatology literature were selected. Methods: In addition to gene polymorphisms several laboratory parameters osteocalcin, parathormone, vitamine D were investigated. Independent Samples t-test and Mann-Whitney-U test were used to compare several demographic and clinical parameters between the groups. P -value  0.05 was accepted to be statistically significant. Results: Having the heterozygous GA genotype of IL-23R rs1004819 and the heterozygous CT genotype of Il-23R rs7530511 significantly increase the risk of developing OP adjusted OR: 3.51, p  0.031 and OR: 2.41, p  0.027, respectively. The wild homozygous GG genotype of Il-23R rs11209032 had higher osteocalcin levels compared with the mutant homozygous AA genotype 18.75  9.76, p  0.009. Conclusions: Our findings suggest that several IL-23R gene polymorphisms are seen more often in osteoporosis patients than in healthy volunteers. In addition, some SNPs were related to higher serum osteocalcin levels.

 Objectives: Osteoporosis OP is a usual disease with a possible genetic predisposition. IL-23 plays a role in physiological bone remodeling and regulates the activity of cells of the bone either directly or indirectly on bone-resorbing osteoclasts as well as on bone-forming osteoblasts. Recent animal and human trials have revealed the main pro-osteoclastogenic activities for the IL-23 pathway. We examined nine single nucleotide polymorphisms SNPs in the interleukin-23 receptor IL-23R in 100 OP patients and gender- and age-matched 96 healthy volunteers. The most analyzed SNPs in the recent rheumatology literature were selected. Methods: In addition to gene polymorphisms several laboratory parameters osteocalcin, parathormone, vitamine D were investigated. Independent Samples t-test and Mann-Whitney-U test were used to compare several demographic and clinical parameters between the groups. P -value  0.05 was accepted to be statistically significant. Results: Having the heterozygous GA genotype of IL-23R rs1004819 and the heterozygous CT genotype of Il-23R rs7530511 significantly increase the risk of developing OP adjusted OR: 3.51, p  0.031 and OR: 2.41, p  0.027, respectively. The wild homozygous GG genotype of Il-23R rs11209032 had higher osteocalcin levels compared with the mutant homozygous AA genotype 18.75  9.76, p  0.009. Conclusions: Our findings suggest that several IL-23R gene polymorphisms are seen more often in osteoporosis patients than in healthy volunteers. In addition, some SNPs were related to higher serum osteocalcin levels.

 Objectives: Osteoporosis OP is a usual disease with a possible genetic predisposition. IL-23 plays a role in physiological bone remodeling and regulates the activity of cells of the bone either directly or indirectly on bone-resorbing osteoclasts as well as on bone-forming osteoblasts. Recent animal and human trials have revealed the main pro-osteoclastogenic activities for the IL-23 pathway. We examined nine single nucleotide polymorphisms SNPs in the interleukin-23 receptor IL-23R in 100 OP patients and gender- and age-matched 96 healthy volunteers. The most analyzed SNPs in the recent rheumatology literature were selected. Methods: In addition to gene polymorphisms several laboratory parameters osteocalcin, parathormone, vitamine D were investigated. Independent Samples t-test and Mann-Whitney-U test were used to compare several demographic and clinical parameters between the groups. P -value  0.05 was accepted to be statistically significant. Results: Having the heterozygous GA genotype of IL-23R rs1004819 and the heterozygous CT genotype of Il-23R rs7530511 significantly increase the risk of developing OP adjusted OR: 3.51, p  0.031 and OR: 2.41, p  0.027, respectively. The wild homozygous GG genotype of Il-23R rs11209032 had higher osteocalcin levels compared with the mutant homozygous AA genotype 18.75  9.76, p  0.009. Conclusions: Our findings suggest that several IL-23R gene polymorphisms are seen more often in osteoporosis patients than in healthy volunteers. In addition, some SNPs were related to higher serum osteocalcin levels.

 Objectives: Osteoporosis OP is a usual disease with a possible genetic predisposition. IL-23 plays a role in physiological bone remodeling and regulates the activity of cells of the bone either directly or indirectly on bone-resorbing osteoclasts as well as on bone-forming osteoblasts. Recent animal and human trials have revealed the main pro-osteoclastogenic activities for the IL-23 pathway. We examined nine single nucleotide polymorphisms SNPs in the interleukin-23 receptor IL-23R in 100 OP patients and gender- and age-matched 96 healthy volunteers. The most analyzed SNPs in the recent rheumatology literature were selected. Methods: In addition to gene polymorphisms several laboratory parameters osteocalcin, parathormone, vitamine D were investigated. Independent Samples t-test and Mann-Whitney-U test were used to compare several demographic and clinical parameters between the groups. P -value  0.05 was accepted to be statistically significant. Results: Having the heterozygous GA genotype of IL-23R rs1004819 and the heterozygous CT genotype of Il-23R rs7530511 significantly increase the risk of developing OP adjusted OR: 3.51, p  0.031 and OR: 2.41, p  0.027, respectively. The wild homozygous GG genotype of Il-23R rs11209032 had higher osteocalcin levels compared with the mutant homozygous AA genotype 18.75  9.76, p  0.009. Conclusions: Our findings suggest that several IL-23R gene polymorphisms are seen more often in osteoporosis patients than in healthy volunteers. In addition, some SNPs were related to higher serum osteocalcin levels.

Makale detayları

Interleukin-23 receptor gene polymorphisms in osteoporosis

Yazarlar:

Firdevs Ulutaş | Ozan Çetin | Veli Çobankara

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Rheumatology and Arthritis

Dergi:

The European Research Journal Vol.9 Issue 6, pp.1277-1285

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001294088

pISSN:

2149-3189

Osteoporosis

interleukin 23 receptor

gene polymorphisms

osteocalcin

Sayı

Makale detayları

Interleukin-23 receptor gene polymorphisms in osteoporosis

Yazarlar: Firdevs Ulutaş | Ozan Çetin | Veli Çobankara

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Rheumatology and Arthritis

Dergi: The European Research Journal Vol.9 Issue 6, pp.1277-1285

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001294088

pISSN: 2149-3189

Osteoporosis

interleukin 23 receptor

gene polymorphisms

osteocalcin

Sayı

Yazarlar:

Firdevs Ulutaş | Ozan Çetin | Veli Çobankara

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Rheumatology and Arthritis

Dergi:

The European Research Journal Vol.9 Issue 6, pp.1277-1285

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001294088

pISSN:

2149-3189