Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies

Peruze AYHAN EŞİYOK; Özlem SEVEN; Gülüzar EYMUR; Gamze BORA TATAR; Didem DAYANGAÇ ERDEN; Kemal YELEKÇİ; Hayat YURTER; Ayhan Sıtkı DEMİR

doi:https://doi.org/10.3906/kim-1305-56

Makale detayları

Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies

Yazarlar:

Peruze AYHAN EŞİYOK | Özlem SEVEN | Gülüzar EYMUR | Gamze BORA TATAR | Didem DAYANGAÇ ERDEN | Kemal YELEKÇİ | Hayat YURTER | Ayhan Sıtkı DEMİR

Yayıncı:

TUBITAK

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Turkish Journal of Chemistry 2014 Vol.38 Issue 2, pp.338-344

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000727232

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1305-56

Özet:

 

New aryl butenoic acid derivatives have been synthesized by combining  hydroxy- or methoxy-substituted phenyl rings as the capping group, with a  double bond in the short linker as well as metal binding groups, enoic  ester, and salts bearing either methyl or morpholine. These compounds have  been shown to possess promising histone deacetylase inhibition activities  via in vitro fluorometric assay and molecular docking studies.

 

New aryl butenoic acid derivatives have been synthesized by combining  hydroxy- or methoxy-substituted phenyl rings as the capping group, with a  double bond in the short linker as well as metal binding groups, enoic  ester, and salts bearing either methyl or morpholine. These compounds have  been shown to possess promising histone deacetylase inhibition activities  via in vitro fluorometric assay and molecular docking studies.

Makale detayları

Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies

Yazarlar: Peruze AYHAN EŞİYOK | Özlem SEVEN | Gülüzar EYMUR | Gamze BORA TATAR | Didem DAYANGAÇ ERDEN | Kemal YELEKÇİ | Hayat YURTER | Ayhan Sıtkı DEMİR

Yayıncı: TUBITAK

Ana Başlıklar: Kimya ve ilgili bilimler

Dergi: Turkish Journal of Chemistry 2014 Vol.38 Issue 2, pp.338-344

Belge Tipi: Makale

Yayın Tarihi: 5/2014

Belge Dili: İngilizce

Document ID (Org No.): 2000727232

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

DOI: https://doi.org/10.3906/kim-1305-56

Sayı

Yazarlar:

Peruze AYHAN EŞİYOK | Özlem SEVEN | Gülüzar EYMUR | Gamze BORA TATAR | Didem DAYANGAÇ ERDEN | Kemal YELEKÇİ | Hayat YURTER | Ayhan Sıtkı DEMİR

Yayıncı:

TUBITAK

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Turkish Journal of Chemistry 2014 Vol.38 Issue 2, pp.338-344

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000727232

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1305-56