Serum prolidase activity in patients with degenerative and rheumatic heart valve diseases

Murat Bülent RABUŞ; Recep DEMİRBAĞ; Yusuf SEZEN; Mehmet TAŞAR; Abdullah TAŞKIN; Nurten AKSOY; Kaan KIRALİ; Cevat YAKUT

Makale detayları

Serum prolidase activity in patients with degenerative and rheumatic heart valve diseases

Yazarlar:

Murat Bülent RABUŞ | Recep DEMİRBAĞ | Yusuf SEZEN | Mehmet TAŞAR | Abdullah TAŞKIN | Nurten AKSOY | Kaan KIRALİ | Cevat YAKUT

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 5, pp.687-692

Belge Tipi:

Makale

Yayın Tarihi:

4/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754932

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

It is known that renin-angiotensin system, inflammation, signaling pathways, and genetic predisposition play a major role in the pathogenesis of heart valve disease. Scarring and collagen deposition in the valves and destruction of myocytes may result from the combined effects of rheumatic and degenerative process in heart valve diseases. Prolidase plays an important role in collagen metabolism, matrix remodeling and cell growth. The aim of the study was to comparatively assess the serum prolidase activity in rheumatic and degenerative heart valve diseases.  Materials and methods: The study included 26 patients who had undergone valve replacement due to rheumatic etiology (Group I), 24 patients who had undergone valve replacement due to degenerative etiology (Group II) and 20 healthy volunteers (Group III). Prolidase activity was determined in all subjects. High sensitive C-reactive protein and white blood cell count were studied in only valve patients.   Results: Prolidase activity was significantly greater in control group than in patients group (51.23.± 5.9 U/L vs. 39.40 ± 4.6 U/L, respectively; P  0.05).   Conclusion: These results suggested that rheumatic and degenerative heart valve diseases seem to be associated with decreased serum prolidase activity.

 

It is known that renin-angiotensin system, inflammation, signaling pathways, and genetic predisposition play a major role in the pathogenesis of heart valve disease. Scarring and collagen deposition in the valves and destruction of myocytes may result from the combined effects of rheumatic and degenerative process in heart valve diseases. Prolidase plays an important role in collagen metabolism, matrix remodeling and cell growth. The aim of the study was to comparatively assess the serum prolidase activity in rheumatic and degenerative heart valve diseases.  Materials and methods: The study included 26 patients who had undergone valve replacement due to rheumatic etiology (Group I), 24 patients who had undergone valve replacement due to degenerative etiology (Group II) and 20 healthy volunteers (Group III). Prolidase activity was determined in all subjects. High sensitive C-reactive protein and white blood cell count were studied in only valve patients.   Results: Prolidase activity was significantly greater in control group than in patients group (51.23.± 5.9 U/L vs. 39.40 ± 4.6 U/L, respectively; P  0.05).   Conclusion: These results suggested that rheumatic and degenerative heart valve diseases seem to be associated with decreased serum prolidase activity.

Makale detayları

Serum prolidase activity in patients with degenerative and rheumatic heart valve diseases

Yazarlar:

Murat Bülent RABUŞ | Recep DEMİRBAĞ | Yusuf SEZEN | Mehmet TAŞAR | Abdullah TAŞKIN | Nurten AKSOY | Kaan KIRALİ | Cevat YAKUT

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 5, pp.687-692

Belge Tipi:

Makale

Yayın Tarihi:

4/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754932

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Prolidase activity

rheumatic valve disease

degenerative valve disease

Sayı

Makale detayları

Serum prolidase activity in patients with degenerative and rheumatic heart valve diseases

Yazarlar: Murat Bülent RABUŞ | Recep DEMİRBAĞ | Yusuf SEZEN | Mehmet TAŞAR | Abdullah TAŞKIN | Nurten AKSOY | Kaan KIRALİ | Cevat YAKUT

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2010 Vol.40 Issue 5, pp.687-692

Belge Tipi: Makale

Yayın Tarihi: 4/2010

Belge Dili: Türkçe

Document ID (Org No.): 2000754932

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Prolidase activity

rheumatic valve disease

degenerative valve disease

Sayı

Yazarlar:

Murat Bülent RABUŞ | Recep DEMİRBAĞ | Yusuf SEZEN | Mehmet TAŞAR | Abdullah TAŞKIN | Nurten AKSOY | Kaan KIRALİ | Cevat YAKUT

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 5, pp.687-692

Belge Tipi:

Makale

Yayın Tarihi:

4/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754932

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144