Metabolic Imaging of Sinonasal Lesions: Diagnostic Value of F18-FDG PET/CT in a Retrospective Cohort

Emine Göknur Işık; Dilşat Fırat Arslan; Doğu Vurallı Bakkaloğlu; Cömert Şen

Makale detayları

Metabolic Imaging of Sinonasal Lesions: Diagnostic Value of F18-FDG PET/CT in a Retrospective Cohort

Yazarlar:

Emine Göknur Işık | Dilşat Fırat Arslan | Doğu Vurallı Bakkaloğlu | Cömert Şen

Yayıncı:

Istanbul University

Ana Başlıklar:

Otorhinolaryngology

Dergi:

The Turkish Journal of Ear Nose and Throat Vol.35 Issue 3, pp.122-128

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001360102

pISSN:

2602-4837

Anahtar kelimeler:

Özet:

 Objective: The objective of this study was to explore the diagnostic value of F18-FDG PETCT in distinguishing benign from malignant sinonasal lesions and, to examine its association with histological subtypes, metastatic spread, and clinical outcomes. Material and Methods: This study retrospectively analysed a cohort of 64 individuals 43 males and 21 females; average age: 52.2 years who had histopathologically confirmed sinonasal lesions and underwent F18-FDG PETCT imaging. The quantitative assessment included the measurement of SUVmax, MTV metabolic tumour volume, and TLG total lesion glycolysis. Receiver operating characteristic curve analysis was performed to determine the most appropriate threshold values for the diagnostic parameters. The relationships between the PETCT f indings and the metastatic status, as well as the clinical outcomes, were assessed. Information regarding lymph node involvement, distant dissemination, and patient outcomes was systematically documented. Results: Of the 67 PETCT scans, 57 89.1 were malignant. A higher mean SUVmax was observed in the malignant lesions relative to the benign counterparts 18.34 vs. 10.83, demonstrating moderate accuracy for malignancy detection, as reflected by an AUC of 0.708 p0.076. The optimal SUVmax cut-off 9.47 yielded 57.1 specificity and 82.5 sensitivity AUC: 0.708; 95 CI: 0.4640.925. MTV and TLG showed limited discriminatory power. PETCT detected distant metastases and regional lymph nodes in 52.6 of the malignant cases, influencing treatment decisions. No meaningful correlation could be established between the PET-derived parameters and overall survival in the study cohort. Conclusion: F18-FDG PETCT provides moderate diagnostic accuracy in sinonasal lesions, with SUVmax being the most informative parameter. Its greatest clinical value lies in the staging and detection of metastatic disease, supporting its use as a complementary imaging modality in sinonasal tumour management. The findings highlight the value of incorporating PETCT into the initial staging process for sinonasal tumours to enhance therapeutic decision-making.

 Objective: The objective of this study was to explore the diagnostic value of F18-FDG PETCT in distinguishing benign from malignant sinonasal lesions and, to examine its association with histological subtypes, metastatic spread, and clinical outcomes. Material and Methods: This study retrospectively analysed a cohort of 64 individuals 43 males and 21 females; average age: 52.2 years who had histopathologically confirmed sinonasal lesions and underwent F18-FDG PETCT imaging. The quantitative assessment included the measurement of SUVmax, MTV metabolic tumour volume, and TLG total lesion glycolysis. Receiver operating characteristic curve analysis was performed to determine the most appropriate threshold values for the diagnostic parameters. The relationships between the PETCT f indings and the metastatic status, as well as the clinical outcomes, were assessed. Information regarding lymph node involvement, distant dissemination, and patient outcomes was systematically documented. Results: Of the 67 PETCT scans, 57 89.1 were malignant. A higher mean SUVmax was observed in the malignant lesions relative to the benign counterparts 18.34 vs. 10.83, demonstrating moderate accuracy for malignancy detection, as reflected by an AUC of 0.708 p0.076. The optimal SUVmax cut-off 9.47 yielded 57.1 specificity and 82.5 sensitivity AUC: 0.708; 95 CI: 0.4640.925. MTV and TLG showed limited discriminatory power. PETCT detected distant metastases and regional lymph nodes in 52.6 of the malignant cases, influencing treatment decisions. No meaningful correlation could be established between the PET-derived parameters and overall survival in the study cohort. Conclusion: F18-FDG PETCT provides moderate diagnostic accuracy in sinonasal lesions, with SUVmax being the most informative parameter. Its greatest clinical value lies in the staging and detection of metastatic disease, supporting its use as a complementary imaging modality in sinonasal tumour management. The findings highlight the value of incorporating PETCT into the initial staging process for sinonasal tumours to enhance therapeutic decision-making.

 Objective: The objective of this study was to explore the diagnostic value of F18-FDG PETCT in distinguishing benign from malignant sinonasal lesions and, to examine its association with histological subtypes, metastatic spread, and clinical outcomes. Material and Methods: This study retrospectively analysed a cohort of 64 individuals 43 males and 21 females; average age: 52.2 years who had histopathologically confirmed sinonasal lesions and underwent F18-FDG PETCT imaging. The quantitative assessment included the measurement of SUVmax, MTV metabolic tumour volume, and TLG total lesion glycolysis. Receiver operating characteristic curve analysis was performed to determine the most appropriate threshold values for the diagnostic parameters. The relationships between the PETCT f indings and the metastatic status, as well as the clinical outcomes, were assessed. Information regarding lymph node involvement, distant dissemination, and patient outcomes was systematically documented. Results: Of the 67 PETCT scans, 57 89.1 were malignant. A higher mean SUVmax was observed in the malignant lesions relative to the benign counterparts 18.34 vs. 10.83, demonstrating moderate accuracy for malignancy detection, as reflected by an AUC of 0.708 p0.076. The optimal SUVmax cut-off 9.47 yielded 57.1 specificity and 82.5 sensitivity AUC: 0.708; 95 CI: 0.4640.925. MTV and TLG showed limited discriminatory power. PETCT detected distant metastases and regional lymph nodes in 52.6 of the malignant cases, influencing treatment decisions. No meaningful correlation could be established between the PET-derived parameters and overall survival in the study cohort. Conclusion: F18-FDG PETCT provides moderate diagnostic accuracy in sinonasal lesions, with SUVmax being the most informative parameter. Its greatest clinical value lies in the staging and detection of metastatic disease, supporting its use as a complementary imaging modality in sinonasal tumour management. The findings highlight the value of incorporating PETCT into the initial staging process for sinonasal tumours to enhance therapeutic decision-making.

 Objective: The objective of this study was to explore the diagnostic value of F18-FDG PETCT in distinguishing benign from malignant sinonasal lesions and, to examine its association with histological subtypes, metastatic spread, and clinical outcomes. Material and Methods: This study retrospectively analysed a cohort of 64 individuals 43 males and 21 females; average age: 52.2 years who had histopathologically confirmed sinonasal lesions and underwent F18-FDG PETCT imaging. The quantitative assessment included the measurement of SUVmax, MTV metabolic tumour volume, and TLG total lesion glycolysis. Receiver operating characteristic curve analysis was performed to determine the most appropriate threshold values for the diagnostic parameters. The relationships between the PETCT f indings and the metastatic status, as well as the clinical outcomes, were assessed. Information regarding lymph node involvement, distant dissemination, and patient outcomes was systematically documented. Results: Of the 67 PETCT scans, 57 89.1 were malignant. A higher mean SUVmax was observed in the malignant lesions relative to the benign counterparts 18.34 vs. 10.83, demonstrating moderate accuracy for malignancy detection, as reflected by an AUC of 0.708 p0.076. The optimal SUVmax cut-off 9.47 yielded 57.1 specificity and 82.5 sensitivity AUC: 0.708; 95 CI: 0.4640.925. MTV and TLG showed limited discriminatory power. PETCT detected distant metastases and regional lymph nodes in 52.6 of the malignant cases, influencing treatment decisions. No meaningful correlation could be established between the PET-derived parameters and overall survival in the study cohort. Conclusion: F18-FDG PETCT provides moderate diagnostic accuracy in sinonasal lesions, with SUVmax being the most informative parameter. Its greatest clinical value lies in the staging and detection of metastatic disease, supporting its use as a complementary imaging modality in sinonasal tumour management. The findings highlight the value of incorporating PETCT into the initial staging process for sinonasal tumours to enhance therapeutic decision-making.

Makale detayları

Metabolic Imaging of Sinonasal Lesions: Diagnostic Value of F18-FDG PET/CT in a Retrospective Cohort

Yazarlar:

Emine Göknur Işık | Dilşat Fırat Arslan | Doğu Vurallı Bakkaloğlu | Cömert Şen

Yayıncı:

Istanbul University

Ana Başlıklar:

Otorhinolaryngology

Dergi:

The Turkish Journal of Ear Nose and Throat Vol.35 Issue 3, pp.122-128

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001360102

pISSN:

2602-4837

Head and neck neoplasms

sinonasal tumours

F18-FDG PET/CT

metabolic imaging

metabolic charac terisation

Sayı

Makale detayları

Metabolic Imaging of Sinonasal Lesions: Diagnostic Value of F18-FDG PET/CT in a Retrospective Cohort

Yazarlar: Emine Göknur Işık | Dilşat Fırat Arslan | Doğu Vurallı Bakkaloğlu | Cömert Şen

Yayıncı: Istanbul University

Ana Başlıklar: Otorhinolaryngology

Dergi: The Turkish Journal of Ear Nose and Throat Vol.35 Issue 3, pp.122-128

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001360102

pISSN: 2602-4837

Head and neck neoplasms

sinonasal tumours

F18-FDG PET/CT

metabolic imaging

metabolic charac terisation

Sayı

Yazarlar:

Emine Göknur Işık | Dilşat Fırat Arslan | Doğu Vurallı Bakkaloğlu | Cömert Şen

Yayıncı:

Istanbul University

Ana Başlıklar:

Otorhinolaryngology

Dergi:

The Turkish Journal of Ear Nose and Throat Vol.35 Issue 3, pp.122-128

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001360102

pISSN:

2602-4837