The prognostic role of neutrophil/lymphocyte ratio and monocyte/lymphocyte ratio in advanced stage gastric cancer patients receiving chemotherapy: a single center experience

Kubilay Karaboyun; Erdoğan Selçuk Şeber

Makale detayları

The prognostic role of neutrophil/lymphocyte ratio and monocyte/lymphocyte ratio in advanced stage gastric cancer patients receiving chemotherapy: a single center experience

Yazarlar:

Kubilay Karaboyun | Erdoğan Selçuk Şeber

Yayıncı:

Hatay Mustafa Kemal University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Interdisciplinary Medical Journal Vol.14 Issue 49, pp.100-104

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001297783

pISSN:

2980-1915

Anahtar kelimeler:

Özet:

 Objective: Several studies revealed that peripheral blood NeutrophilLymphocyte ratio NLR and MonocyteLymphocyte Ratio MLR were prognostic in various cancer types. However, there are no excessive information about the prognostic significance of NLR and MLR in patients with advanced gastric cancer. As a result, we examined whether NLR andor MLR could be used as a prognostic marker to predict survival outcomes in patients with advanced gastric cancer receiving palliative chemotherapy. Method: We retrospectively analyzed 119 patients with gastric cancer receiving chemotherapy. We evaluated the relationship between potential prognostic factors and overall survival OS times using the Kaplan-Meier method and Cox regression survival modelling. Results: The median overall survival of the patients was 6.9 2.1-41.6 months. In univariate analysis, NLR p 0.001, ECOG performance status p 0.001, presence of liver metastases p 0.001 and presence of peritoneal metastases p 0.001 were found to be associated with survival. The multivariate survival model showed the high NLR HR1.59, 95 CI 1.6-2.40, p 0.026, the patients with ECOG performance score 2-3 HR2.91, 95 CI 1.60-5.27, p0.001, the presence of liver metastasis HR2.10, 95 CI 1.35-3.21, p0.001 and the presence of peritoneal metastases HR2.68, 95 CI 1.72-4.17, p0.001 as independent predictors of survival. Conclusion: Pretreatment high NLR, ECOG performance status, and presence of liver or peritoneal metastases are powerful prognostic factors in advanced gastric cancer patients. These prognostic factors, which are easily accessible in clinical practice, can be used as helpful tools for clinicians in the management of the disease.

 Objective: Several studies revealed that peripheral blood NeutrophilLymphocyte ratio NLR and MonocyteLymphocyte Ratio MLR were prognostic in various cancer types. However, there are no excessive information about the prognostic significance of NLR and MLR in patients with advanced gastric cancer. As a result, we examined whether NLR andor MLR could be used as a prognostic marker to predict survival outcomes in patients with advanced gastric cancer receiving palliative chemotherapy. Method: We retrospectively analyzed 119 patients with gastric cancer receiving chemotherapy. We evaluated the relationship between potential prognostic factors and overall survival OS times using the Kaplan-Meier method and Cox regression survival modelling. Results: The median overall survival of the patients was 6.9 2.1-41.6 months. In univariate analysis, NLR p 0.001, ECOG performance status p 0.001, presence of liver metastases p 0.001 and presence of peritoneal metastases p 0.001 were found to be associated with survival. The multivariate survival model showed the high NLR HR1.59, 95 CI 1.6-2.40, p 0.026, the patients with ECOG performance score 2-3 HR2.91, 95 CI 1.60-5.27, p0.001, the presence of liver metastasis HR2.10, 95 CI 1.35-3.21, p0.001 and the presence of peritoneal metastases HR2.68, 95 CI 1.72-4.17, p0.001 as independent predictors of survival. Conclusion: Pretreatment high NLR, ECOG performance status, and presence of liver or peritoneal metastases are powerful prognostic factors in advanced gastric cancer patients. These prognostic factors, which are easily accessible in clinical practice, can be used as helpful tools for clinicians in the management of the disease.

 Objective: Several studies revealed that peripheral blood NeutrophilLymphocyte ratio NLR and MonocyteLymphocyte Ratio MLR were prognostic in various cancer types. However, there are no excessive information about the prognostic significance of NLR and MLR in patients with advanced gastric cancer. As a result, we examined whether NLR andor MLR could be used as a prognostic marker to predict survival outcomes in patients with advanced gastric cancer receiving palliative chemotherapy. Method: We retrospectively analyzed 119 patients with gastric cancer receiving chemotherapy. We evaluated the relationship between potential prognostic factors and overall survival OS times using the Kaplan-Meier method and Cox regression survival modelling. Results: The median overall survival of the patients was 6.9 2.1-41.6 months. In univariate analysis, NLR p 0.001, ECOG performance status p 0.001, presence of liver metastases p 0.001 and presence of peritoneal metastases p 0.001 were found to be associated with survival. The multivariate survival model showed the high NLR HR1.59, 95 CI 1.6-2.40, p 0.026, the patients with ECOG performance score 2-3 HR2.91, 95 CI 1.60-5.27, p0.001, the presence of liver metastasis HR2.10, 95 CI 1.35-3.21, p0.001 and the presence of peritoneal metastases HR2.68, 95 CI 1.72-4.17, p0.001 as independent predictors of survival. Conclusion: Pretreatment high NLR, ECOG performance status, and presence of liver or peritoneal metastases are powerful prognostic factors in advanced gastric cancer patients. These prognostic factors, which are easily accessible in clinical practice, can be used as helpful tools for clinicians in the management of the disease.

 Objective: Several studies revealed that peripheral blood NeutrophilLymphocyte ratio NLR and MonocyteLymphocyte Ratio MLR were prognostic in various cancer types. However, there are no excessive information about the prognostic significance of NLR and MLR in patients with advanced gastric cancer. As a result, we examined whether NLR andor MLR could be used as a prognostic marker to predict survival outcomes in patients with advanced gastric cancer receiving palliative chemotherapy. Method: We retrospectively analyzed 119 patients with gastric cancer receiving chemotherapy. We evaluated the relationship between potential prognostic factors and overall survival OS times using the Kaplan-Meier method and Cox regression survival modelling. Results: The median overall survival of the patients was 6.9 2.1-41.6 months. In univariate analysis, NLR p 0.001, ECOG performance status p 0.001, presence of liver metastases p 0.001 and presence of peritoneal metastases p 0.001 were found to be associated with survival. The multivariate survival model showed the high NLR HR1.59, 95 CI 1.6-2.40, p 0.026, the patients with ECOG performance score 2-3 HR2.91, 95 CI 1.60-5.27, p0.001, the presence of liver metastasis HR2.10, 95 CI 1.35-3.21, p0.001 and the presence of peritoneal metastases HR2.68, 95 CI 1.72-4.17, p0.001 as independent predictors of survival. Conclusion: Pretreatment high NLR, ECOG performance status, and presence of liver or peritoneal metastases are powerful prognostic factors in advanced gastric cancer patients. These prognostic factors, which are easily accessible in clinical practice, can be used as helpful tools for clinicians in the management of the disease.

Makale detayları

The prognostic role of neutrophil/lymphocyte ratio and monocyte/lymphocyte ratio in advanced stage gastric cancer patients receiving chemotherapy: a single center experience

Yazarlar:

Kubilay Karaboyun | Erdoğan Selçuk Şeber

Yayıncı:

Hatay Mustafa Kemal University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Interdisciplinary Medical Journal Vol.14 Issue 49, pp.100-104

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001297783

pISSN:

2980-1915

Gastric Cancer

Chemotherapy

Survival

Neutrophil-Lymphocyte Ratio

Monocyte-Lymphocyte Ratio

Sayı

Makale detayları

The prognostic role of neutrophil/lymphocyte ratio and monocyte/lymphocyte ratio in advanced stage gastric cancer patients receiving chemotherapy: a single center experience

Yazarlar: Kubilay Karaboyun | Erdoğan Selçuk Şeber

Yayıncı: Hatay Mustafa Kemal University

Ana Başlıklar: Clinical Sciences (Other)

Dergi: Interdisciplinary Medical Journal Vol.14 Issue 49, pp.100-104

Belge Tipi: Makale

Yayın Tarihi: 8/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001297783

pISSN: 2980-1915

Gastric Cancer

Chemotherapy

Survival

Neutrophil-Lymphocyte Ratio

Monocyte-Lymphocyte Ratio

Sayı

Yazarlar:

Kubilay Karaboyun | Erdoğan Selçuk Şeber

Yayıncı:

Hatay Mustafa Kemal University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Interdisciplinary Medical Journal Vol.14 Issue 49, pp.100-104

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001297783

pISSN:

2980-1915