Chrysin prevents brain damage caused by global cerebral  ischemia/reperfusion in a C57BL/J6 mouse model

Mehmet Akif DURAK; Mustafa Namik ÖZTANIR; Neşe Başak TÜRKMEN; Osman ÇİFTÇİ; Asli TAŞLIDERE; Mehmet TECELLİOĞLU; Arif ÖNDER

Makale detayları

Chrysin prevents brain damage caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model

Yazarlar:

Mehmet Akif DURAK | Mustafa Namik ÖZTANIR | Neşe Başak TÜRKMEN | Osman ÇİFTÇİ | Asli TAŞLIDERE | Mehmet TECELLİOĞLU | Arif ÖNDER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 6, pp.1926-1933

Belge Tipi:

Makale

Yayın Tarihi:

11/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000751766

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: The present study investigated the neuroprotective effects of chrysin (CRS) following global cerebral ischemia and reperfusion (I/R) in a C57BL/J6 mouse model.   Materials and methods: A total of 40 mice were equally divided into four groups: (1) sham-operated (SH = control), (2) global cerebral I/R (I/R), (3) CRS, and (4) CRS + I/R. In the I/R group, the bilateral carotid arteries were clipped for 15 min and the mice were treated with vehicle (corn oil) for 10 days. In the CRS group, CRS (50 mg/kg) was given for 10 days without carotid occlusion. In the CRS + I/R group bilateral carotid arteries were clipped for 15 min and the mice were also treated with CRS (50 mg/kg) for 10 days. All of the rats were sacrificed under anesthesia on day 10, and neurodegenerative histological changes in the brain and tissue levels of oxidants and antioxidants were evaluated.  Results: CRS treatment significantly reversed the oxidative effects of I/R and inhibited the development of neurodegenerative histopathologies. In the CRS + I/R group, the decrease in TBARS levels and increase in GSH levels were similar to those in the SH group.   Conclusion: Treatment with CRS can positively affect the neural system of mice and it can be used for the treatment of global cerebral I/R.

Makale detayları

Chrysin prevents brain damage caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model

Yazarlar: Mehmet Akif DURAK | Mustafa Namik ÖZTANIR | Neşe Başak TÜRKMEN | Osman ÇİFTÇİ | Asli TAŞLIDERE | Mehmet TECELLİOĞLU | Arif ÖNDER

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2016 Vol.46 Issue 6, pp.1926-1933

Belge Tipi: Makale

Yayın Tarihi: 11/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000751766

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Mehmet Akif DURAK | Mustafa Namik ÖZTANIR | Neşe Başak TÜRKMEN | Osman ÇİFTÇİ | Asli TAŞLIDERE | Mehmet TECELLİOĞLU | Arif ÖNDER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 6, pp.1926-1933

Belge Tipi:

Makale

Yayın Tarihi:

11/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000751766

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144