Investigation of TNF-alpha gene (G308A) and GSTP1 gene (Ile105Val) polymorphisms in Turkish patients with retinopathy of prematurity

Mehmet TÜRE; Meral YILDIZ; Mutlu KARKUCAK; Emine Tuna GÜLTEN; Deniz SIĞIRLI; Ahmet Tuncer ÖZMEN; Tahsin YAKUT

Makale detayları

Investigation of TNF-alpha gene (G308A) and GSTP1 gene (Ile105Val) polymorphisms in Turkish patients with retinopathy of prematurity

Yazarlar:

Mehmet TÜRE | Meral YILDIZ | Mutlu KARKUCAK | Emine Tuna GÜLTEN | Deniz SIĞIRLI | Ahmet Tuncer ÖZMEN | Tahsin YAKUT

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 1, pp.164-169

Belge Tipi:

Makale

Yayın Tarihi:

3/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752899

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Retinopathy of prematurity (ROP) is one of the most frequent causes of blindness in newborn babies. Currently, its etiology is not fully understood. In this study we aimed to investigate the correlation between a patient group with ROP and a control group in terms of the tumor necrosis factor-alpha (TNF-alpha) (G308A) gene and glutathione-S-transferase P1 (GSTP1) (Ile105Val) gene polymorphism.   Materials and methods: Sixty-two patients diagnosed with ROP and 58 control subjects were included in this study. For TNF-alpha (G308A) gene and GSTP1 (Ile105Val) gene polymorphisms, the polymerase chain reaction-restriction fragment length polymorphism method was used. In statistical analysis the significance level was determined as P  0.05).  Conclusion: In our study, no correlation was identified between TNF-alpha (G308A) gene and GSTP1 (Ile105Val) gene polymorphisms and susceptibility for development of ROP. Further studies are required with more cases of ROP patients and other gene polymorphisms that could be related.

 

Retinopathy of prematurity (ROP) is one of the most frequent causes of blindness in newborn babies. Currently, its etiology is not fully understood. In this study we aimed to investigate the correlation between a patient group with ROP and a control group in terms of the tumor necrosis factor-alpha (TNF-alpha) (G308A) gene and glutathione-S-transferase P1 (GSTP1) (Ile105Val) gene polymorphism.   Materials and methods: Sixty-two patients diagnosed with ROP and 58 control subjects were included in this study. For TNF-alpha (G308A) gene and GSTP1 (Ile105Val) gene polymorphisms, the polymerase chain reaction-restriction fragment length polymorphism method was used. In statistical analysis the significance level was determined as P  0.05).  Conclusion: In our study, no correlation was identified between TNF-alpha (G308A) gene and GSTP1 (Ile105Val) gene polymorphisms and susceptibility for development of ROP. Further studies are required with more cases of ROP patients and other gene polymorphisms that could be related.

Makale detayları

Investigation of TNF-alpha gene (G308A) and GSTP1 gene (Ile105Val) polymorphisms in Turkish patients with retinopathy of prematurity

Yazarlar: Mehmet TÜRE | Meral YILDIZ | Mutlu KARKUCAK | Emine Tuna GÜLTEN | Deniz SIĞIRLI | Ahmet Tuncer ÖZMEN | Tahsin YAKUT

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2015 Vol.45 Issue 1, pp.164-169

Belge Tipi: Makale

Yayın Tarihi: 3/2015

Belge Dili: Türkçe

Document ID (Org No.): 2000752899

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

TNF-alpha

GSTP1

gene polymorphism

retinopathy of prematurity

Sayı

Yazarlar:

Mehmet TÜRE | Meral YILDIZ | Mutlu KARKUCAK | Emine Tuna GÜLTEN | Deniz SIĞIRLI | Ahmet Tuncer ÖZMEN | Tahsin YAKUT

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 1, pp.164-169

Belge Tipi:

Makale

Yayın Tarihi:

3/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752899

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144