Anionic polymers based buccoadhesive wafers controlled the release of anticandidal drug miconazole nitrate

N.A.

Makale detayları

Anionic polymers based buccoadhesive wafers controlled the release of anticandidal drug miconazole nitrate

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 3, pp.749-761

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346643

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Oropharyngeal candidiasis, an opportunistic fungal infection, is caused by Candida albicans. Conventional formulations of antifungal drug, miconazole nitrate MN, have limited retention on the infected oral mucosa, leading to its rapid clearance from the affected site. Aim of present study was to design and optimize MN buccal mucoadhesive wafer formulation for enhanced retention time as well as controlled drug release. Varying ratios of anionic, cationic and nonionic polymers were used to prepare wafers by freeze-drying method. Drug excipient interaction studies were performed by fourier transform infrared FT-IR and differential scanning calorimetry DSC analysis. Formulations were further evaluated by various wafer quality assessment parameters. Scanning electron microscopy SEM analysis and X-ray diffraction XRD studies were performed for surface analysis and solid state characterization, respectively, of prepared formulations. In vitro drug release studies of optimized formulations were performed and release kinetics was evaluated. Wafer formulations with anionic polymers exhibited acceptable results of swelling, adhesiveness and folding endurance analysis. Optimized formulations showed controlled release of MN by non-Fickian diffusion. Results suggest that buccoadhesive wafer formulated by anionic polymers may be utilized to achieve desired therapeutic effects of MN.

 Oropharyngeal candidiasis, an opportunistic fungal infection, is caused by Candida albicans. Conventional formulations of antifungal drug, miconazole nitrate MN, have limited retention on the infected oral mucosa, leading to its rapid clearance from the affected site. Aim of present study was to design and optimize MN buccal mucoadhesive wafer formulation for enhanced retention time as well as controlled drug release. Varying ratios of anionic, cationic and nonionic polymers were used to prepare wafers by freeze-drying method. Drug excipient interaction studies were performed by fourier transform infrared FT-IR and differential scanning calorimetry DSC analysis. Formulations were further evaluated by various wafer quality assessment parameters. Scanning electron microscopy SEM analysis and X-ray diffraction XRD studies were performed for surface analysis and solid state characterization, respectively, of prepared formulations. In vitro drug release studies of optimized formulations were performed and release kinetics was evaluated. Wafer formulations with anionic polymers exhibited acceptable results of swelling, adhesiveness and folding endurance analysis. Optimized formulations showed controlled release of MN by non-Fickian diffusion. Results suggest that buccoadhesive wafer formulated by anionic polymers may be utilized to achieve desired therapeutic effects of MN.

 Oropharyngeal candidiasis, an opportunistic fungal infection, is caused by Candida albicans. Conventional formulations of antifungal drug, miconazole nitrate MN, have limited retention on the infected oral mucosa, leading to its rapid clearance from the affected site. Aim of present study was to design and optimize MN buccal mucoadhesive wafer formulation for enhanced retention time as well as controlled drug release. Varying ratios of anionic, cationic and nonionic polymers were used to prepare wafers by freeze-drying method. Drug excipient interaction studies were performed by fourier transform infrared FT-IR and differential scanning calorimetry DSC analysis. Formulations were further evaluated by various wafer quality assessment parameters. Scanning electron microscopy SEM analysis and X-ray diffraction XRD studies were performed for surface analysis and solid state characterization, respectively, of prepared formulations. In vitro drug release studies of optimized formulations were performed and release kinetics was evaluated. Wafer formulations with anionic polymers exhibited acceptable results of swelling, adhesiveness and folding endurance analysis. Optimized formulations showed controlled release of MN by non-Fickian diffusion. Results suggest that buccoadhesive wafer formulated by anionic polymers may be utilized to achieve desired therapeutic effects of MN.

 Oropharyngeal candidiasis, an opportunistic fungal infection, is caused by Candida albicans. Conventional formulations of antifungal drug, miconazole nitrate MN, have limited retention on the infected oral mucosa, leading to its rapid clearance from the affected site. Aim of present study was to design and optimize MN buccal mucoadhesive wafer formulation for enhanced retention time as well as controlled drug release. Varying ratios of anionic, cationic and nonionic polymers were used to prepare wafers by freeze-drying method. Drug excipient interaction studies were performed by fourier transform infrared FT-IR and differential scanning calorimetry DSC analysis. Formulations were further evaluated by various wafer quality assessment parameters. Scanning electron microscopy SEM analysis and X-ray diffraction XRD studies were performed for surface analysis and solid state characterization, respectively, of prepared formulations. In vitro drug release studies of optimized formulations were performed and release kinetics was evaluated. Wafer formulations with anionic polymers exhibited acceptable results of swelling, adhesiveness and folding endurance analysis. Optimized formulations showed controlled release of MN by non-Fickian diffusion. Results suggest that buccoadhesive wafer formulated by anionic polymers may be utilized to achieve desired therapeutic effects of MN.

Makale detayları

Anionic polymers based buccoadhesive wafers controlled the release of anticandidal drug miconazole nitrate

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 3, pp.749-761

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346643

pISSN:

2630-6344

Mucoadhesive

polymer

antifungal

formulation

release kinetics

Sayı

Makale detayları

Anionic polymers based buccoadhesive wafers controlled the release of anticandidal drug miconazole nitrate

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Sciences

Dergi: Journal of Research in Pharmacy Vol.28 Issue 3, pp.749-761

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346643

pISSN: 2630-6344

Mucoadhesive

polymer

antifungal

formulation

release kinetics

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 3, pp.749-761

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346643

pISSN:

2630-6344