A combination of lymphocyte count and albumin concentration as a new prognostic index for Hepatocellular Carcinoma

Ahmet Gökhan Sarıtaş; Uğur Topal; Burak Yavuz; Abdullah Ülkü; Kubilay Dalcı; Orçun Yalav; Cihan Atar; İsmail Cem Eray; Atılgan Tolga Akçam

Makale detayları

A combination of lymphocyte count and albumin concentration as a new prognostic index for Hepatocellular Carcinoma

Yazarlar:

Ahmet Gökhan Sarıtaş | Uğur Topal | Burak Yavuz | Abdullah Ülkü | Kubilay Dalcı | Orçun Yalav | Cihan Atar | İsmail Cem Eray | Atılgan Tolga Akçam

Yayıncı:

Balıkesir University

Ana Başlıklar:

Gastroenteroloji ve Hepatoloji

Dergi:

Balıkesir Medical Journal Vol.8 Issue 1, pp.14-25

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001315322

pISSN:

2564-6664

Anahtar kelimeler:

Özet:

 Aim The present study explores the prognostic significance of the lymphocytes L  albumin gL LA score and its relationship with the hepatocellular carcinoma. Material and Methods The study included patients who underwent curative surgery for hepatocellular carcinoma between January 2004 and November 2020. The LA score was calculated using the formula lymphocytes Lalbumin gL. The patients were subsequently divided into two as Group 1 Low LA and Group 2 High LA. The two groups were compared for clinical characteristics as well as oncological follow-up outcomes. Results The study included 55 patients, who, based on an LA cut-off point of 4620, were divided into Group 1 n28 and Group 2 n27. The MELD score was higher in Group 1 12 vs.9, p0.022. The number of tumors, maximum tumor size and total tumor size were similar in both groups. At the last clinical follow-up, the mortality rate was 42.9 in Group 1 and 22.2 in Group 2. Recurrence rates were similar in both groups 42.9vs.33.3 p0.467, and total survival 126vs.164 months p0.1 and disease-free survival 26 vs. 29 months p0.926 were also similar. Conclusion The use of the composite LA index  an indicator of immunonutritional status as a prognostic marker may not be significant in HCC patients undergoing curative resection.

 Aim The present study explores the prognostic significance of the lymphocytes L  albumin gL LA score and its relationship with the hepatocellular carcinoma. Material and Methods The study included patients who underwent curative surgery for hepatocellular carcinoma between January 2004 and November 2020. The LA score was calculated using the formula lymphocytes Lalbumin gL. The patients were subsequently divided into two as Group 1 Low LA and Group 2 High LA. The two groups were compared for clinical characteristics as well as oncological follow-up outcomes. Results The study included 55 patients, who, based on an LA cut-off point of 4620, were divided into Group 1 n28 and Group 2 n27. The MELD score was higher in Group 1 12 vs.9, p0.022. The number of tumors, maximum tumor size and total tumor size were similar in both groups. At the last clinical follow-up, the mortality rate was 42.9 in Group 1 and 22.2 in Group 2. Recurrence rates were similar in both groups 42.9vs.33.3 p0.467, and total survival 126vs.164 months p0.1 and disease-free survival 26 vs. 29 months p0.926 were also similar. Conclusion The use of the composite LA index  an indicator of immunonutritional status as a prognostic marker may not be significant in HCC patients undergoing curative resection.

 Aim The present study explores the prognostic significance of the lymphocytes L  albumin gL LA score and its relationship with the hepatocellular carcinoma. Material and Methods The study included patients who underwent curative surgery for hepatocellular carcinoma between January 2004 and November 2020. The LA score was calculated using the formula lymphocytes Lalbumin gL. The patients were subsequently divided into two as Group 1 Low LA and Group 2 High LA. The two groups were compared for clinical characteristics as well as oncological follow-up outcomes. Results The study included 55 patients, who, based on an LA cut-off point of 4620, were divided into Group 1 n28 and Group 2 n27. The MELD score was higher in Group 1 12 vs.9, p0.022. The number of tumors, maximum tumor size and total tumor size were similar in both groups. At the last clinical follow-up, the mortality rate was 42.9 in Group 1 and 22.2 in Group 2. Recurrence rates were similar in both groups 42.9vs.33.3 p0.467, and total survival 126vs.164 months p0.1 and disease-free survival 26 vs. 29 months p0.926 were also similar. Conclusion The use of the composite LA index  an indicator of immunonutritional status as a prognostic marker may not be significant in HCC patients undergoing curative resection.

 Amaç Bu çalışmanın amacı, lenfosit L  albümin gL LA skorunun prognostik önemini ve hepatosellüler karsinom ile olan ilişkisini araştırmaktır. Gereç ve Yöntemler Çalışma, Ocak 2004 ile Kasım 2020 arasında hepatosellüler karsinoma için küratif cerrahi yapılan hastaları kapsamaktadır. Lenfosit-AlbumünLA skoru, lenfosit Lalbümin gL formülü kullanılarak hesaplanmıştır. Hastalar daha sonra Düşük LA Grup 1 ve Yüksek LA Grup 2 olmak üzere iki gruba ayrılmıştır. İki grup, klinik özellikler ve onkolojik takip sonuçları açısından karşılaştırılmıştır. Sonuçlar Çalışma, 4620 LA kesim noktasına göre Grup 1 n28 ve Grup 2 n27 olarak ayrılan 55 hastayı içermektedir. MELD skoru Grup 1de daha yüksekti 12ye karşı 9, p0.022. Tümör sayısı, maksimum tümör boyutu ve toplam tümör boyutu her iki grupta benzerdi. Klinik takipte takipte, Grup 1deki mortalite oranı 42.9 iken, Grup 2de 22.2 idi. Nüks oranları her iki grupta benzer bulunmuştur 42.9a karşı 33.3, p0.467, toplam sağkalım 126ya karşı 164 ay, p0.1 ve hastalıksız sağkalım 26ya karşı 29 ay, p0.926 oranları da benzer bulunmuştur. Sonuç Küratif rezeksiyon geçiren HCC hastalarında, immünonütrisyonel durumun bir göstergesi olan bileşik LA indeksinin prognostik bir işaretçi olarak kullanımı anlamlı olmayabilir.

Makale detayları

A combination of lymphocyte count and albumin concentration as a new prognostic index for Hepatocellular Carcinoma

Yazarlar:

Ahmet Gökhan Sarıtaş | Uğur Topal | Burak Yavuz | Abdullah Ülkü | Kubilay Dalcı | Orçun Yalav | Cihan Atar | İsmail Cem Eray | Atılgan Tolga Akçam

Yayıncı:

Balıkesir University

Ana Başlıklar:

Gastroenteroloji ve Hepatoloji

Dergi:

Balıkesir Medical Journal Vol.8 Issue 1, pp.14-25

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001315322

pISSN:

2564-6664

Carcinoma

Hepatocellular

Immunity

Lymphocytes

Nutritional Status

Serum Albumin.Hepatosellüler karsinom

İmmünite

Lenfosit

Nütrisyonel durum

Serum Albumini

Sayı

Makale detayları

Yazarlar: Ahmet Gökhan Sarıtaş | Uğur Topal | Burak Yavuz | Abdullah Ülkü | Kubilay Dalcı | Orçun Yalav | Cihan Atar | İsmail Cem Eray | Atılgan Tolga Akçam

Yayıncı: Balıkesir University

Ana Başlıklar: Gastroenteroloji ve Hepatoloji

Dergi: Balıkesir Medical Journal Vol.8 Issue 1, pp.14-25

Belge Tipi: Makale

Yayın Tarihi: 4/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001315322

pISSN: 2564-6664

Sayı

Yazarlar:

Ahmet Gökhan Sarıtaş | Uğur Topal | Burak Yavuz | Abdullah Ülkü | Kubilay Dalcı | Orçun Yalav | Cihan Atar | İsmail Cem Eray | Atılgan Tolga Akçam

Yayıncı:

Balıkesir University

Ana Başlıklar:

Gastroenteroloji ve Hepatoloji

Dergi:

Balıkesir Medical Journal Vol.8 Issue 1, pp.14-25

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001315322

pISSN:

2564-6664