Genotype and allele frequencies of SLCO1B1 g.89595 T>C  polymorphism in a healthy Turkish population

Zuhal Uçkun Şahinoğulları; Necmiye Canacankatan

Makale detayları

Genotype and allele frequencies of SLCO1B1 g.89595 T>C polymorphism in a healthy Turkish population

Yazarlar:

Zuhal Uçkun Şahinoğulları | Necmiye Canacankatan

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Toxicology

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 6, pp.1149-1156

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347964

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Many xenobiotic and endogenous compounds are transported from blood into hepatocytes mediated by organic anion transporter protein OATP1B1, which is encoded by solute carrier organic anion transporter family member 1B1 SLCO1B1 gene. Genetic polymorphisms in SLCO1B1 gene can affect in pharmacokinetics of most compounds and may cause changes in drug efficacy and advers reactions. Thus, genetic polymorphism analysis of genes that may affect the pharmacokinetics of compounds is extremely important. The goal of this study was to determine the genotype and allele frequencies of SLCO1B1 g.89595 TC polymorphism in a healthy Turkish population and also to compare our results with the findings of other previously reported populations. Genotyping analyses of SLCO1B1 g.89595 TC polymorphism was carried out in 68 healthy Turkish volunteers by a polymerase chain reaction restriction fragment length polymorphism method. The frequencies of the TT, TC, and CC genotypes were 77.9, 19.1 and 3.0, respectively. Also, the frequencies of T and C alleles were 87.5 and 12.5, respectively. The genotype frequencies were consistent with HardyWeinberg equilibrium. The results of the study are compared with those of other ethnic groups, and they displayed pronounced ethnic group differences, especially East Asian and Southeast ancestry. The detection of SLCO1B1 polymorphisms may ensure benefits for adjustment of dosage regimens of some drugs and protecting from andor decreasing adverse events, and also for future studies concerning SLCO1B1 transporter and its polymorphisms.

 Many xenobiotic and endogenous compounds are transported from blood into hepatocytes mediated by organic anion transporter protein OATP1B1, which is encoded by solute carrier organic anion transporter family member 1B1 SLCO1B1 gene. Genetic polymorphisms in SLCO1B1 gene can affect in pharmacokinetics of most compounds and may cause changes in drug efficacy and advers reactions. Thus, genetic polymorphism analysis of genes that may affect the pharmacokinetics of compounds is extremely important. The goal of this study was to determine the genotype and allele frequencies of SLCO1B1 g.89595 TC polymorphism in a healthy Turkish population and also to compare our results with the findings of other previously reported populations. Genotyping analyses of SLCO1B1 g.89595 TC polymorphism was carried out in 68 healthy Turkish volunteers by a polymerase chain reaction restriction fragment length polymorphism method. The frequencies of the TT, TC, and CC genotypes were 77.9, 19.1 and 3.0, respectively. Also, the frequencies of T and C alleles were 87.5 and 12.5, respectively. The genotype frequencies were consistent with HardyWeinberg equilibrium. The results of the study are compared with those of other ethnic groups, and they displayed pronounced ethnic group differences, especially East Asian and Southeast ancestry. The detection of SLCO1B1 polymorphisms may ensure benefits for adjustment of dosage regimens of some drugs and protecting from andor decreasing adverse events, and also for future studies concerning SLCO1B1 transporter and its polymorphisms.

 Many xenobiotic and endogenous compounds are transported from blood into hepatocytes mediated by organic anion transporter protein OATP1B1, which is encoded by solute carrier organic anion transporter family member 1B1 SLCO1B1 gene. Genetic polymorphisms in SLCO1B1 gene can affect in pharmacokinetics of most compounds and may cause changes in drug efficacy and advers reactions. Thus, genetic polymorphism analysis of genes that may affect the pharmacokinetics of compounds is extremely important. The goal of this study was to determine the genotype and allele frequencies of SLCO1B1 g.89595 TC polymorphism in a healthy Turkish population and also to compare our results with the findings of other previously reported populations. Genotyping analyses of SLCO1B1 g.89595 TC polymorphism was carried out in 68 healthy Turkish volunteers by a polymerase chain reaction restriction fragment length polymorphism method. The frequencies of the TT, TC, and CC genotypes were 77.9, 19.1 and 3.0, respectively. Also, the frequencies of T and C alleles were 87.5 and 12.5, respectively. The genotype frequencies were consistent with HardyWeinberg equilibrium. The results of the study are compared with those of other ethnic groups, and they displayed pronounced ethnic group differences, especially East Asian and Southeast ancestry. The detection of SLCO1B1 polymorphisms may ensure benefits for adjustment of dosage regimens of some drugs and protecting from andor decreasing adverse events, and also for future studies concerning SLCO1B1 transporter and its polymorphisms.

 Many xenobiotic and endogenous compounds are transported from blood into hepatocytes mediated by organic anion transporter protein OATP1B1, which is encoded by solute carrier organic anion transporter family member 1B1 SLCO1B1 gene. Genetic polymorphisms in SLCO1B1 gene can affect in pharmacokinetics of most compounds and may cause changes in drug efficacy and advers reactions. Thus, genetic polymorphism analysis of genes that may affect the pharmacokinetics of compounds is extremely important. The goal of this study was to determine the genotype and allele frequencies of SLCO1B1 g.89595 TC polymorphism in a healthy Turkish population and also to compare our results with the findings of other previously reported populations. Genotyping analyses of SLCO1B1 g.89595 TC polymorphism was carried out in 68 healthy Turkish volunteers by a polymerase chain reaction restriction fragment length polymorphism method. The frequencies of the TT, TC, and CC genotypes were 77.9, 19.1 and 3.0, respectively. Also, the frequencies of T and C alleles were 87.5 and 12.5, respectively. The genotype frequencies were consistent with HardyWeinberg equilibrium. The results of the study are compared with those of other ethnic groups, and they displayed pronounced ethnic group differences, especially East Asian and Southeast ancestry. The detection of SLCO1B1 polymorphisms may ensure benefits for adjustment of dosage regimens of some drugs and protecting from andor decreasing adverse events, and also for future studies concerning SLCO1B1 transporter and its polymorphisms.

Makale detayları

Genotype and allele frequencies of SLCO1B1 g.89595 T>C polymorphism in a healthy Turkish population

Yazarlar:

Zuhal Uçkun Şahinoğulları | Necmiye Canacankatan

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Toxicology

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 6, pp.1149-1156

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347964

pISSN:

2630-6344

SLCO1B1

drug transporter

genetic polymorphism

Turkish population

Sayı

Makale detayları

Genotype and allele frequencies of SLCO1B1 g.89595 T>C polymorphism in a healthy Turkish population

Yazarlar: Zuhal Uçkun Şahinoğulları | Necmiye Canacankatan

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Toxicology

Dergi: Journal of Research in Pharmacy Vol.23 Issue 6, pp.1149-1156

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347964

pISSN: 2630-6344

SLCO1B1

drug transporter

genetic polymorphism

Turkish population

Sayı

Yazarlar:

Zuhal Uçkun Şahinoğulları | Necmiye Canacankatan

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Toxicology

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 6, pp.1149-1156

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347964

pISSN:

2630-6344