T1 relaxation time in the evaluation of liver fibrosis; with native MR relaxometry

Firathan Sarıaltın

Makale detayları

T1 relaxation time in the evaluation of liver fibrosis; with native MR relaxometry

Yazarlar:

Firathan Sarıaltın

Yayıncı:

Marmara University

Ana Başlıklar:

Clinical Sciences

Dergi:

Marmara Medical Journal Vol.36 Issue 2, pp.197-202

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289751

pISSN:

1019-1941

Anahtar kelimeler:

Özet:

 Objective: Non-invasive methods have been investigated as an alternative to biopsy in assessing liver fibrosis. This study aimed to evaluate the relationship between liver T1 relaxation time and liver fibrosis as a non-invasive alternative method. Patients and Methods: This study analyzed 1.5T magnetic resonance MR images of 86 patients retrospectively. The participants were divided into two groups: patients with chronic hepatitis and the control group. Native variable flip angle VFA T1 mapping technique was used to estimate liver T1 relaxation time. T1 mapping sequence, T2 mapping sequence, and image analysis were performed. The liver size, the spleen size, the liver T1 relaxation time, and the liver T2 relaxation time were recorded. Results: The T1 relaxation time was 758.4  121.1 ms in the chronic hepatitis group and 600.2  67 ms in the control group. The T1 relaxation time of the patient group was significantly higher than that of the control group p0.001. The spleen size of the patient group was statistically significantly larger than the control group p0.001. There was a significant positive correlation between liver T1 relaxation time and Ishak score r0.683, p0.001. Also, a significant positive correlation was observed between T1 relaxation time and histological activity index score r0.542, p0.001. Conclusion: A native T1 map is a non-invasive method that works as an alternative to biopsy in the follow-up and diagnosis of chronic hepatitis. Moreover, this method can be used to measure liver T1 relaxation time in patients with liver fibrosis.

 Objective: Non-invasive methods have been investigated as an alternative to biopsy in assessing liver fibrosis. This study aimed to evaluate the relationship between liver T1 relaxation time and liver fibrosis as a non-invasive alternative method. Patients and Methods: This study analyzed 1.5T magnetic resonance MR images of 86 patients retrospectively. The participants were divided into two groups: patients with chronic hepatitis and the control group. Native variable flip angle VFA T1 mapping technique was used to estimate liver T1 relaxation time. T1 mapping sequence, T2 mapping sequence, and image analysis were performed. The liver size, the spleen size, the liver T1 relaxation time, and the liver T2 relaxation time were recorded. Results: The T1 relaxation time was 758.4  121.1 ms in the chronic hepatitis group and 600.2  67 ms in the control group. The T1 relaxation time of the patient group was significantly higher than that of the control group p0.001. The spleen size of the patient group was statistically significantly larger than the control group p0.001. There was a significant positive correlation between liver T1 relaxation time and Ishak score r0.683, p0.001. Also, a significant positive correlation was observed between T1 relaxation time and histological activity index score r0.542, p0.001. Conclusion: A native T1 map is a non-invasive method that works as an alternative to biopsy in the follow-up and diagnosis of chronic hepatitis. Moreover, this method can be used to measure liver T1 relaxation time in patients with liver fibrosis.

 Objective: Non-invasive methods have been investigated as an alternative to biopsy in assessing liver fibrosis. This study aimed to evaluate the relationship between liver T1 relaxation time and liver fibrosis as a non-invasive alternative method. Patients and Methods: This study analyzed 1.5T magnetic resonance MR images of 86 patients retrospectively. The participants were divided into two groups: patients with chronic hepatitis and the control group. Native variable flip angle VFA T1 mapping technique was used to estimate liver T1 relaxation time. T1 mapping sequence, T2 mapping sequence, and image analysis were performed. The liver size, the spleen size, the liver T1 relaxation time, and the liver T2 relaxation time were recorded. Results: The T1 relaxation time was 758.4  121.1 ms in the chronic hepatitis group and 600.2  67 ms in the control group. The T1 relaxation time of the patient group was significantly higher than that of the control group p0.001. The spleen size of the patient group was statistically significantly larger than the control group p0.001. There was a significant positive correlation between liver T1 relaxation time and Ishak score r0.683, p0.001. Also, a significant positive correlation was observed between T1 relaxation time and histological activity index score r0.542, p0.001. Conclusion: A native T1 map is a non-invasive method that works as an alternative to biopsy in the follow-up and diagnosis of chronic hepatitis. Moreover, this method can be used to measure liver T1 relaxation time in patients with liver fibrosis.

 Objective: Non-invasive methods have been investigated as an alternative to biopsy in assessing liver fibrosis. This study aimed to evaluate the relationship between liver T1 relaxation time and liver fibrosis as a non-invasive alternative method. Patients and Methods: This study analyzed 1.5T magnetic resonance MR images of 86 patients retrospectively. The participants were divided into two groups: patients with chronic hepatitis and the control group. Native variable flip angle VFA T1 mapping technique was used to estimate liver T1 relaxation time. T1 mapping sequence, T2 mapping sequence, and image analysis were performed. The liver size, the spleen size, the liver T1 relaxation time, and the liver T2 relaxation time were recorded. Results: The T1 relaxation time was 758.4  121.1 ms in the chronic hepatitis group and 600.2  67 ms in the control group. The T1 relaxation time of the patient group was significantly higher than that of the control group p0.001. The spleen size of the patient group was statistically significantly larger than the control group p0.001. There was a significant positive correlation between liver T1 relaxation time and Ishak score r0.683, p0.001. Also, a significant positive correlation was observed between T1 relaxation time and histological activity index score r0.542, p0.001. Conclusion: A native T1 map is a non-invasive method that works as an alternative to biopsy in the follow-up and diagnosis of chronic hepatitis. Moreover, this method can be used to measure liver T1 relaxation time in patients with liver fibrosis.

Makale detayları

T1 relaxation time in the evaluation of liver fibrosis; with native MR relaxometry

Yazarlar:

Firathan Sarıaltın

Yayıncı:

Marmara University

Ana Başlıklar:

Clinical Sciences

Dergi:

Marmara Medical Journal Vol.36 Issue 2, pp.197-202

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289751

pISSN:

1019-1941

Fibrosis

Liver

MRI

Relaxometry

T1

Sayı

Makale detayları

T1 relaxation time in the evaluation of liver fibrosis; with native MR relaxometry

Yazarlar: Firathan Sarıaltın

Yayıncı: Marmara University

Ana Başlıklar: Clinical Sciences

Dergi: Marmara Medical Journal Vol.36 Issue 2, pp.197-202

Belge Tipi: Makale

Yayın Tarihi: 5/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001289751

pISSN: 1019-1941

Fibrosis

Liver

MRI

Relaxometry

T1

Sayı

Yazarlar:

Firathan Sarıaltın

Yayıncı:

Marmara University

Ana Başlıklar:

Clinical Sciences

Dergi:

Marmara Medical Journal Vol.36 Issue 2, pp.197-202

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289751

pISSN:

1019-1941