Antioxidant, xanthine oxidase inhibitory and antibacterial activities of selected galactogogue Thai medicinal plant water and ethyl acetate extracts

N.A.

Makale detayları

Antioxidant, xanthine oxidase inhibitory and antibacterial activities of selected galactogogue Thai medicinal plant water and ethyl acetate extracts

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 4, pp.519-530

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348091

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Water and ethyl acetate extracts of sixteen galactogogue Thai medicinal plants collected in Northeastern Thailand were evaluated for the antioxidant activity in terms of 2,2-diphenyl-1-picrylhydrazyl DPPH radical scavenging property and total phenolic content TPC, xanthine oxidase inhibitory and antibacterial activities. Among the extracts, both of the water and ethyl acetate extracts from the stem bark of Caesalpinia sappan CS and Ochna integerrima OI exhibited potent DPPH radical scavenging capacity IC50 9.47  0.59  13.25  0.52 gmL as compared to ascorbic acid IC50 5.39  0.32 gmL and high TPC 632.89  10.18  985.34  0.76 mg gallic acid equivalent GAEg of extract. The strongest xanthine oxidase inhibitory property was detected in the ethyl acetate extract from the root of Clausena harmandiana CH followed by CS and OI extracts showing inhibition of 99.22  0.22, 78.00  0.79 and 68.67  1.14, respectively, at the tested concentration of 50 µgmL and referenced to allopurinol. The water extracts of CS and OI also possessed good antibacterial activity against eight tested pathogenic bacteria especially Gram-positive, S. aureus MSSA DMST 2933, S. aureus MRSA DMST 20651 and Bacillus cereus ATCC 1 1 7 7 8 , with the MIC and MBC values ranging from 0.39  1.56 mgmL. The antibacterial property of OI extract and xanthine oxidase inhibitory activity of CH and OI extracts were first reported.

 Water and ethyl acetate extracts of sixteen galactogogue Thai medicinal plants collected in Northeastern Thailand were evaluated for the antioxidant activity in terms of 2,2-diphenyl-1-picrylhydrazyl DPPH radical scavenging property and total phenolic content TPC, xanthine oxidase inhibitory and antibacterial activities. Among the extracts, both of the water and ethyl acetate extracts from the stem bark of Caesalpinia sappan CS and Ochna integerrima OI exhibited potent DPPH radical scavenging capacity IC50 9.47  0.59  13.25  0.52 gmL as compared to ascorbic acid IC50 5.39  0.32 gmL and high TPC 632.89  10.18  985.34  0.76 mg gallic acid equivalent GAEg of extract. The strongest xanthine oxidase inhibitory property was detected in the ethyl acetate extract from the root of Clausena harmandiana CH followed by CS and OI extracts showing inhibition of 99.22  0.22, 78.00  0.79 and 68.67  1.14, respectively, at the tested concentration of 50 µgmL and referenced to allopurinol. The water extracts of CS and OI also possessed good antibacterial activity against eight tested pathogenic bacteria especially Gram-positive, S. aureus MSSA DMST 2933, S. aureus MRSA DMST 20651 and Bacillus cereus ATCC 1 1 7 7 8 , with the MIC and MBC values ranging from 0.39  1.56 mgmL. The antibacterial property of OI extract and xanthine oxidase inhibitory activity of CH and OI extracts were first reported.

 Water and ethyl acetate extracts of sixteen galactogogue Thai medicinal plants collected in Northeastern Thailand were evaluated for the antioxidant activity in terms of 2,2-diphenyl-1-picrylhydrazyl DPPH radical scavenging property and total phenolic content TPC, xanthine oxidase inhibitory and antibacterial activities. Among the extracts, both of the water and ethyl acetate extracts from the stem bark of Caesalpinia sappan CS and Ochna integerrima OI exhibited potent DPPH radical scavenging capacity IC50 9.47  0.59  13.25  0.52 gmL as compared to ascorbic acid IC50 5.39  0.32 gmL and high TPC 632.89  10.18  985.34  0.76 mg gallic acid equivalent GAEg of extract. The strongest xanthine oxidase inhibitory property was detected in the ethyl acetate extract from the root of Clausena harmandiana CH followed by CS and OI extracts showing inhibition of 99.22  0.22, 78.00  0.79 and 68.67  1.14, respectively, at the tested concentration of 50 µgmL and referenced to allopurinol. The water extracts of CS and OI also possessed good antibacterial activity against eight tested pathogenic bacteria especially Gram-positive, S. aureus MSSA DMST 2933, S. aureus MRSA DMST 20651 and Bacillus cereus ATCC 1 1 7 7 8 , with the MIC and MBC values ranging from 0.39  1.56 mgmL. The antibacterial property of OI extract and xanthine oxidase inhibitory activity of CH and OI extracts were first reported.

 Water and ethyl acetate extracts of sixteen galactogogue Thai medicinal plants collected in Northeastern Thailand were evaluated for the antioxidant activity in terms of 2,2-diphenyl-1-picrylhydrazyl DPPH radical scavenging property and total phenolic content TPC, xanthine oxidase inhibitory and antibacterial activities. Among the extracts, both of the water and ethyl acetate extracts from the stem bark of Caesalpinia sappan CS and Ochna integerrima OI exhibited potent DPPH radical scavenging capacity IC50 9.47  0.59  13.25  0.52 gmL as compared to ascorbic acid IC50 5.39  0.32 gmL and high TPC 632.89  10.18  985.34  0.76 mg gallic acid equivalent GAEg of extract. The strongest xanthine oxidase inhibitory property was detected in the ethyl acetate extract from the root of Clausena harmandiana CH followed by CS and OI extracts showing inhibition of 99.22  0.22, 78.00  0.79 and 68.67  1.14, respectively, at the tested concentration of 50 µgmL and referenced to allopurinol. The water extracts of CS and OI also possessed good antibacterial activity against eight tested pathogenic bacteria especially Gram-positive, S. aureus MSSA DMST 2933, S. aureus MRSA DMST 20651 and Bacillus cereus ATCC 1 1 7 7 8 , with the MIC and MBC values ranging from 0.39  1.56 mgmL. The antibacterial property of OI extract and xanthine oxidase inhibitory activity of CH and OI extracts were first reported.

Makale detayları

Antioxidant, xanthine oxidase inhibitory and antibacterial activities of selected galactogogue Thai medicinal plant water and ethyl acetate extracts

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 4, pp.519-530

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348091

pISSN:

2630-6344

Antioxidant activity

xanthine oxidase inhibition

antibacterial activity

galactogogue

DPPH

total phenolic content.

Sayı

Makale detayları

Antioxidant, xanthine oxidase inhibitory and antibacterial activities of selected galactogogue Thai medicinal plant water and ethyl acetate extracts

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacognosy

Dergi: Journal of Research in Pharmacy Vol.25 Issue 4, pp.519-530

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001348091

pISSN: 2630-6344

Antioxidant activity

xanthine oxidase inhibition

antibacterial activity

galactogogue

DPPH

total phenolic content.

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 4, pp.519-530

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348091

pISSN:

2630-6344