A New Approach to Furan-Containing Macrolactones

Christoph Q. SCHMIDT; Ruth MESSMER; Franz BRACHER; Jürgen KRAUSS

Makale detayları

A New Approach to Furan-Containing Macrolactones

Yazarlar:

Christoph Q. SCHMIDT | Ruth MESSMER | Franz BRACHER | Jürgen KRAUSS

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2007 Vol.31 Issue 3, pp.251-256

Belge Tipi:

Makale

Yayın Tarihi:

2/2007

Belge Dili:

Türkçe

Document ID (Org No.):

2000728699

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Furan and tetrahydrofuran heterocycles are part of many  natural products, like the Galerucella pheromone, furano epothilones,  bipinnatin, and amphidinolides.  This paper describes a short and  efficient synthetic approach to furan-containing macrolactones in 4  steps, including as key steps a Sonogashira reaction and an olefin  metathesis.  The resulting compounds were tested at the National  Cancer Institute for their cytotoxicity, but did not exhibit  significant cytotoxicity in the human tumour cell line screen.

 

Furan and tetrahydrofuran heterocycles are part of many  natural products, like the Galerucella pheromone, furano epothilones,  bipinnatin, and amphidinolides.  This paper describes a short and  efficient synthetic approach to furan-containing macrolactones in 4  steps, including as key steps a Sonogashira reaction and an olefin  metathesis.  The resulting compounds were tested at the National  Cancer Institute for their cytotoxicity, but did not exhibit  significant cytotoxicity in the human tumour cell line screen.

Makale detayları

A New Approach to Furan-Containing Macrolactones

Yazarlar: Christoph Q. SCHMIDT | Ruth MESSMER | Franz BRACHER | Jürgen KRAUSS

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2007 Vol.31 Issue 3, pp.251-256

Belge Tipi: Makale

Yayın Tarihi: 2/2007

Belge Dili: Türkçe

Document ID (Org No.): 2000728699

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Christoph Q. SCHMIDT | Ruth MESSMER | Franz BRACHER | Jürgen KRAUSS

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2007 Vol.31 Issue 3, pp.251-256

Belge Tipi:

Makale

Yayın Tarihi:

2/2007

Belge Dili:

Türkçe

Document ID (Org No.):

2000728699

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527